Retroperitoneal castleman disease mimicking lymph node spread from clear renal cell carcinoma. A case report

Abstract

Renal Cell Carcinoma (RCC) corresponds to 3% of the neoplasms in the adults. Surgery is the main mode of treatment, which can be associated toretroperitoneal lymphadenectomy in the presence of clinically tumor positive lymph nodes. Castleman Disease (CD) is a rare lymphoproliferative disorder, with little-known etiopathogenesis. It rarely affects the retroperitoneum. Thorax, neck, and abdomen are more frequently affected. Therefore, CD can simulate lymphatic spread from RCC to the retroperitoneum, also leading to a possible misdiagnosis, or diagnosis concerning a paraneoplastic syndrome due to RCC.

Severe Inflammatory Idiopathic Multicentric Castleman’s Disease Coexisting with Advanced Renal Cancer: A Case Report

“…It is considered that renal cancer causes the release of various inflammatory cytokines, such as IL-6, and induces CD as a paraneoplastic syndrome. To date, seven cases have been reported, including our case, of coexisting renal cancer and CD (Table 2) (Tissier et al 1998;Chan et al 2010;Chen et al 2016;Dong et al 2019;Vishwajeet et al 2019;de Campos et al 2021). According to previous reports, complete surgical resection could be effective in patients with coexisting renal cancer and CD.…”

“…The diagnostic criteria for CD require the exclusion of malignant tumors. Additionally, there are only seven cases, including our case, in which CD and malignant tumors coexist (Tissier et al 1998;Chan et al 2010;Chen et al 2016;Dong et al 2019;Vishwajeet et al 2019;de Campos et al 2021). Herein, we report a rare case of advanced renal cancer coexisting with CD.…”