Retroperitoneal hemangiopericytoma associated with hypoglycemia: Report of a case

Yasuda, Yoshikazu; Kasahara, Kogoro; Tenmoku, Sumio; Yabe, Chikaharu; Miyapa, Michio; Morioka, Yasuhiko; Sakamoto, Yoshikazu; Kuzuya, Tsunehiko; Takeda, Kentaro; Atsumi, T; Shimizu, Hideo; Matsumoto, Saburo

doi:10.1007/bf02468636

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…16,19,[21][22][23][24] These are considered true meningeal hemangiopericytomas of mesenchymatous origin. 25,26 It is not unusual for hemangiopericytoma in general to be associated with hypoglycemia 10,12,16,[27][28][29][30][31][32][33][34][35] but to our knowledge, to date only four articles 16,17,36,37 have reported meningeal hemangiopericytoma with liver metastasis and hypoglycemia. In some cases, 35,37 Surgical resection of the tumor and, when possible, of the metastasis, is the best cause-based treatment.…”

Section: Discussionmentioning

confidence: 99%

Hepatic and pulmonary metastases from a meningeal hemangiopericytoma and severe hypoglycemia due to abnormal secretion of insulin-like growth factor

Grünenberger

Bachellier

Chenard

et al. 1999

Cancer

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Section: Discussionmentioning

confidence: 99%

Hepatic and pulmonary metastases from a meningeal hemangiopericytoma and severe hypoglycemia due to abnormal secretion of insulin-like growth factor

Grünenberger

Bachellier

Chenard

et al. 1999

Cancer

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“…Prompt relief was obtained after food intake. Removal of the tumour has been followed by a disappearance of the patient's symptoms (1,5,28) and a normalization of the blood serum levels of glucose (Table 1) and insulin (2, 5, 21,56).…”

Section: Igf-2 Ria Of Patient's Blood With Subsequent Gel Chromatogramentioning

confidence: 99%

High‐molecular weight IGF‐2 expression in a haemangiopericytoma associated with hypoglycaemia

Höög

Nordqvist

Hulting

et al. 1997

APMIS

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Spontaneous hypoglycaemia is usually caused by an insulin‐producing islet‐cell tumour of the pancreas. Rarely, it can be caused by non‐islet cell tumours. Most of the tumours are of mesenchymal type, large, and slowly growing. One representative is haemangiopericytoma (HAP). The present report describes a case of a large recurrent retroperitoneal HAP associated with severe hypoglycaemia. Blood serum insulin and proinsulin concentrations were low. By means of acid‐gel chromatography and dot‐blot techniques, an increased amount of a high‐molecular‐weight IGF‐2 peptide was found. By using antigen retrieval procedures, IGF‐2‐immunoreactive tumour cells were found in specimens of the recent tumour recurrence ‐ but not in the original. When the in situ hybridization technique was used it could be shown that IGF‐2 mRNA labelling had already occurred in the original tumour specimen, 11 years before the onset of hypoglycaemic symptoms. These observations confirm the hypothesized hypoglycaemic effects of high‐molecular‐weight (HMW) IGF‐2, but also point to the presence of a prolonged compensation of this effect. A literature review, based on 17 similar cases of haemangiopericytoma with hypoglycaemia, is presented. Our observation and findings in the literature review support the idea that non‐islet‐cell tumour hypoglycaemia is caused by an overproduction of a HMW IGF‐2 peptide. The insulin‐like effect is mediated via non‐specific binding to the insulin receptors. To anticipate patients at risk of developing this kind of hypoglycaemia, the histopathological investigation should include not only immunohistochemical analyses of the presence of IGF‐2 peptide, but also in situ hybridization of the IGF‐2 mRNA expression.

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Malignant hemangiopericytoma of the liver: Report of a case

Sano

Terada

Hayashi

et al. 1991

The Japanese Journal of Surgery

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A 30 year old female was admitted with right upper abdominal pain and fever. Ultrasonography and computed tomography revealed a large cystic mass in the right lobe of the liver, and aspiration bacteriology was negative. A right hepatic lobectomy was performed for a suspected cystadenocarcinoma, however, the tumor was histologically diagnosed as a hemangiopericytoma with prominent venous invasion. The patient died within a short time of multiple pulmonary metastases. Primary hepatic hemangiopericytoma is extremely rare, and according to our research, this is only the 4th case reported in the literature.

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Retroperitoneal hemangiopericytoma associated with hypoglycemia: Report of a case

Cited by 7 publications

References 12 publications

Hepatic and pulmonary metastases from a meningeal hemangiopericytoma and severe hypoglycemia due to abnormal secretion of insulin-like growth factor

Hepatic and pulmonary metastases from a meningeal hemangiopericytoma and severe hypoglycemia due to abnormal secretion of insulin-like growth factor

High‐molecular weight IGF‐2 expression in a haemangiopericytoma associated with hypoglycaemia

Malignant hemangiopericytoma of the liver: Report of a case

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