Retroperitoneal unicentric Castleman’s disease: A case report

Abdessayed, Nihed; Bdioui, Ahlem; Ammar, Houssem; Gupta, Rahul; Mhamdi, Nozha; Guerfela, Marwa; Mokni, Moncef

doi:10.1016/j.ijscr.2016.12.023

Cited by 8 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study performed by The American Society of Hematology used a humanized anti IL-6 receptor antibody to treat patients with multicentric plasma cell or mixed type CD. After the administration of this antibody Weisenburger et al [16], a clinical response was achieved [11][12][13][14]. Also, when histopathological examination was performed, pathological response was noted with a reduction of follicular hyperplasia and vascularity [15][16][17][18].…”

Section: Discussionmentioning

confidence: 96%

“…For this reason, radiotherapy should be considered for a poor surgical candidate or for unresectable unicentric CD. A study by Yoshizaki et al [7] demonstrated that, in fact, the cells present in the germinal centers of the hyperplastic lymph nodes produce IL-6 and found a correlation of this production with the serum levels of IL-67 Abdessayed et al [13]. Thus, another treatment modality that has been proposed is the blockage of the IL-6 dysregulated overproduction [7,11], especially in patients with plasma-cell variant [11] & Ren et al [14].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Unicentric Castleman’s Disease: Case Report and Literature Review

Rivera¹

2018

CTOIJ

View full text Add to dashboard Cite

Castleman's disease (CD), also known as giant lymph node hyperplasia or angiofollicular lymph node dysplasia, is a rare benign immunoproliferative disorder. CD is classified by histopathologic appearance (hyaline vascular, plasma cell or mix variant) as well as by the number of lymph nodes that are involved (unicentric and multicentric). We report the case of a 24-year-old female who was found to have unicentric anterior mediastinum CD. This article describes the clinical features, pathogenesis, diagnosis, and current treatment modalities for this uncommon disease.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Unicentric Castleman’s Disease: Case Report and Literature Review

Rivera¹

2018

CTOIJ

View full text Add to dashboard Cite

show abstract

“…In addition, the patient's serum levels of carcinoembryonic antigen (CEA), cancer antigen (CA) 19-9, CA125, and interleukin 6 (IL-6) were within the normal range. While the mass is usually detected incidentally, as Nakata et al (9) reported, it can also manifest itself with specific symptoms caused by the effect of the mass or adjacent organs (10,11). There have been individuals reported with palpable masses and dyspeptic symptoms (10,11).…”

Section: Discussionmentioning

confidence: 99%

Case Report of an Incidental Unicentric Castleman Disease

Cengiz¹,

Certel²,

Ayrik³

et al. 2021

tmsj

View full text Add to dashboard Cite

“…The HP examination showed large lymphoid follicles in the form of "onion skin", atrophic germinal centers with concentric rings of B-lymphocytes. On the other hand, a hyalinization at the stromal level was found, without an aggregation of the plasma cells [47].…”

Section: Figure 6 -Castleman Disease Section Through the Mantle Zonementioning

confidence: 90%

“…As a particularity of the case, we have to mention that the identification of the origin of the retroperitoneal mass was facilitated by the fact that the patient had an ipsilateral ovarian cyst [33]. Abdessayed et al (2017) published another case of a 34-year-old patient complaining of epigastric pain, especially postprandial. The results of the biochemistry examinations did not reveal anything significant.…”

Section: Figure 6 -Castleman Disease Section Through the Mantle Zonementioning

confidence: 99%

Untitled

2020

Rom J Morphol Embryol

View full text Add to dashboard Cite

The most frequent tumoral condition of the uterus is represented by uterine myoma. The diagnosis, in most cases, is established by clinical examination and ultrasound scan. Nevertheless, there are rare cases, in which the surgical findings reveal a retroperitoneal tumor instead of a uterine myoma. These could be represented by schwannomas or Castleman disease. The schwannomas are rarely malignant and arise from the Schwann cells of nerve fibers. These tumors are frequently found at the level of the head, neck and mediastinum and rarely in the pelvis. Generally, schwannomas localized at retroperitoneal level are asymptomatic and with a very slow growth rate. The treatment consists in complete surgical resection. The recurrence rate is low and, generally, the prognosis is good. The Castleman disease is considered a rare entity, but it should be always taken into consideration when it comes to a differential diagnosis in a young patient who presents a retroperitoneal mass at imagery exams. The condition affects the lymphatic system and is characterized by a hyperplasia of the lymph nodes, sometimes associated with herpes virus infection. The clinical picture is often non-specific; the pain may be the only symptom. The imaging methods are not always conclusive for the final positive diagnosis and the histopathological examination is always necessary. Pelvic Castleman disease can be misdiagnosed as myoma or an adnexal tumor. In this article, we review the present knowledge regarding the pathogenesis, pathology and management of these rare retroperitoneal tumors. Both conditions, when located in pelvis must be taken into consideration in the differential diagnosis of uterine myomas, especially in the pedunculated form.

show abstract

Retroperitoneal unicentric Castleman’s disease: A case report

Cited by 8 publications

References 15 publications

Unicentric Castleman’s Disease: Case Report and Literature Review

Unicentric Castleman’s Disease: Case Report and Literature Review

Case Report of an Incidental Unicentric Castleman Disease

Untitled

Contact Info

Product

Resources

About