Retrospective analysis of forward and reverse ABO typing discrepancies among patients and blood donors in a tertiary care hospital

Abstract

The resolution of ABO typing discrepancy is essential to minimise the chance of transfusion of ABO-incompatible blood.

Accurate cisAB typing is essential to ensure the safety of a transfusion: A case of a cisAB01 neurosurgery pediatric patient and family study

“…Among pretransfusion compatibility tests, an accurate interpretation of ABO group discrepancies is critical to ensure patient transfusion safety in good practices. 1 The current perspective of blood typing tests is to reduce missed subgroup detection to avoid incorrect transfusion. Here, we present a case of a pediatric patient with a cis AB blood type undergoing elective neurosurgery and the pedigree of the propositus family.…”

A novel Bruton tyrosine kinase gene variation was found in an adult with X‐linked agammaglobulinemia during blood cross‐matching prior to surgical operation

“…Clerical errors, procedural problems and red cell and/or serum‐related problems (Chiaroni et al, ; Kaur et al, ; Sharma et al, ) may cause ABO typing discrepancies, which should be resolved to minimise the likelihood of ABO‐incompatible blood transfusion. The incidence of ABO typing discrepancies in patients is 0·1% (Makroo et al, ). The major cause of forward typing discrepancies is ABO subgroups, and the most common cause of reverse typing discrepancies is the presence of cold autoantibodies (50·7%), followed by weak/missing antibodies (25·4%).…”

“…The major cause of forward typing discrepancies is ABO subgroups, and the most common cause of reverse typing discrepancies is the presence of cold autoantibodies (50·7%), followed by weak/missing antibodies (25·4%). Age‐related weak or missing antibodies and immunosuppressive drugs for post‐renal transplant recipients are the major causes of weak antibody activity (Makroo et al, ). Humoral immunodeficiency diseases, such as common variable immunodeficiency, are characterized by missing antibodies, which can also cause an ABO discrepancy (Julius et al, ; Oh et al, ).…”

Resolution of an unexpected ABO typing discrepancy in a 9‐month‐old patient with juvenile myelomonocytic leukemia

“…ABO typing discrepancies are relatively uncommon occurrences in the hospital transfusion service but are routinely encountered in the setting of hematopoietic progenitor cell transplantation (HPCT). 1 We were challenged recently with a typing discrepancy that occurred in a 9-month-old male patient who underwent an unrelated allogeneic umbilical cord blood transplant for juvenile myelomonocytic leukemia. The discrepancy was resolved but shed light on the value of utilizing the simple, yet informative ABO type to monitor HPCT patients in order to provide feedback on engraftment status and the immunologic resetting that occurs post-transplantation.…”

“…ABO typing discrepancies are relatively uncommon occurrences in the hospital transfusion service but are routinely encountered in the setting of hematopoietic progenitor cell transplantation (HPCT) 1 . We were challenged recently with a typing discrepancy that occurred in a 9‐month‐old male patient who underwent an unrelated allogeneic umbilical cord blood transplant for juvenile myelomonocytic leukemia.…”