Retrospective investigation of IgM antibodies against Zika virus in serum from febrile patients in Mozambique, 2009–2015

Chelene, Imelda; Ali, Sádia; Mula, Flora; Muianga, Argentina Felisbela; Monteiro, Vanessa; Oludele, John; Chongo, Inocêncio; José, Américo; Amade, Nádia Alves; António, Virgílio; Gudo, Eduardo Samo

doi:10.1186/s13104-019-4511-x

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…Data on ZIKV epidemiology are scarce in the country. This study reported a frequency of IgM anti-ZIKV of 9.2%, which is higher than the prevalence of 4.9% found in a recent retrospective study conducted among febrile children aged 1 to 15 years old in Mozambique (20), suggesting that the frequency of ZIKV is increasing in the country. Similar to CHIKV, we believe that several factors are behind the potential increase in the frequency of ZIKV, such as human behaviors and climate and environmental changes (21-23) (24).…”

Section: Discussioncontrasting

confidence: 78%

“…The higher frequency of IgM antibodies against CHIKV and ZIKV among malaria positive cases as compared to that found among febrile patients is a matter for further investigation but might suggest an overlap in the circulation of malaria, CHIKV and ZIKV in Mozambique. This study found a higher frequency of co-occurrence of IgM anti-CHIKV and malaria as compared to previous studies conducted in the country (13, 20), as well as in other countries in the continent (31-33).…”

Section: Discussioncontrasting

confidence: 57%

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Investigation of antibodies against Chikungunya, Dengue and Zika virus in serum samples from febrile patients and its co-occurrence with malaria in six districts highly endemic for malaria in Mozambique between 2017 – 2018

Ali-Pereira

Inlamea

Muianga

et al. 2022

Preprint

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Introduction : Arboviruses and malaria are both mosquito-borne diseases, with overlapping symptoms and geographic distribution in tropical settings. However, little information is available on the co-occurrence of arboviruses and malaria in areas highly endemic for malaria in Africa. This study was conducted with the aim to determine the frequency of recent Dengue (DENV), Chikungunya (CHIKV) and Zika (ZIKV) infections and their co-occurrence with malaria in six highly endemic districts for malaria in Mozambique. Methods: Blood samples were collected from febrile outpatients between January 2017 and December 2018 and were then tested for Malaria using RDT. Serum samples from these patients were also tested using commercially available ELISA for the presence of IgM antibodies against CHIKV, ZIKV and DENV, as well as NS1 antigen for DENV. Concurrently, a questionnaire was administered to collect socio-demographic characteristics of patients. Results: Of the 906 participants enrolled, IgM antibodies against CHIKV, DENV and ZIKV were identified in 134 (14.8%), 64 (7.4%) and 83 (9.2%) individuals, respectively. Malaria was diagnosed in 56 (6.2%) participants, of which 16 (28.6%) were also positive for IgM anti CHIKV, 1 (1.8%) for DENV-NS1, 3 (5.4%) for IgM anti-DENV and 10 (17.8%) for IgM anti-ZIKV. There was a trend towards an increase in the frequency of IgM anti CHIKV positive samples, from 7.0% in 2014 to 14.8% in 2018 and IgM anti-ZIKV positive samples increased from 4.9% in 2015 to 9.2% in 2018. Conclusion : This study showed an increased frequency of arbovirus in Mozambique thus far, as well as a frequent occurrence of arbovirus among malaria positive patients. This highlighted the urgency for the establishment of sentinel surveillance sites for arboviruses and the need for an integrated management of febrile illnesses in places where arboviruses and malaria are both prevalent.

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Section: Discussioncontrasting

confidence: 78%

Section: Discussioncontrasting

confidence: 57%

Investigation of antibodies against Chikungunya, Dengue and Zika virus in serum samples from febrile patients and its co-occurrence with malaria in six districts highly endemic for malaria in Mozambique between 2017 – 2018

Ali-Pereira

Inlamea

Muianga

et al. 2022

Preprint

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“…Although the real burden of arboviral and zoonotic diseases is unknown in the country due to the lack of a surveillance system for these diseases, dengue has been recognized as an emerging public health problem, especially in the city of Pemba, Cabo Delgado province, where it caused two outbreaks, the most recent in 2014 (6,7). Conversely, although outbreaks of Chikungunya, Zika, and Leptospirosis have not been clearly detected, serological studies have pointed to their endemic transmission across the country (8)(9)(10)(11)(12)(13). Furthermore, Aedes mosquitoes (Ae.…”

Section: Introductionmentioning

confidence: 99%

Surveillance for arboviruses and leptospirosis among non-malarial acute febrile illness outpatients in areas affected by Cyclones Idai and Kenneth in Mozambique

Mugabe

Inlamea²,

Ali³

et al. 2023

Front. Trop. Dis

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The floods associated with the landfall of cyclones Idai and Kenneth in Mozambique between March and April 2019 had a major impact on the country’s public health and placed the affected population at risk for vector- and rodent-borne diseases. Aiming to improve the diagnostic capacity, yield information to guide public health responses, and assess potential short-term effects of cyclones Idai and Kenneth on arboviruses (dengue, Zika, and chikungunya) and leptospirosis, a clinical and laboratory surveillance for non-malarial acute febrile illness was established in six health units located in different districts within the two provinces (Sofala and Cabo Delgado) affected by the cyclones. Patients were tested using real-time reverse transcriptase polymerase chain reaction (qRT-PCR) for dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV) viruses and using enzyme linked immunoassays (ELISA) to detect nonstructural DENV protein 1 (NS1), as well as DENV, ZIKV, CHIKV, and Leptospira IgM antibodies. From April to September 2019, 305 patients aged ≥15 years were enrolled, of which 58.4% were women and the median age was 30 years old. All patients were qRT-PCR negative for the targeted arboviruses, but three (1.0%) were positive for DENV NS1 ELISA. Specific IgM antibodies against DENV, ZIKV, CHIKV or Leptospira were found in the serum of 104 (34.1%) patients. Our results indicate that vector- and rodent-borne disease transmission occurred in all districts under investigation in the wake of cyclones Idai and Kenneth, including some regions where cases had not been previously detected. The investigation provided useful information for post-cyclone emergency response purposes.

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A historical perspective on arboviruses of public health interest in Southern Africa

Hungwe,

Laycock,

Ntereke

et al. 2023

Pathogens and Global Health

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Retrospective investigation of IgM antibodies against Zika virus in serum from febrile patients in Mozambique, 2009–2015

Cited by 3 publications

References 16 publications

Investigation of antibodies against Chikungunya, Dengue and Zika virus in serum samples from febrile patients and its co-occurrence with malaria in six districts highly endemic for malaria in Mozambique between 2017 – 2018

Investigation of antibodies against Chikungunya, Dengue and Zika virus in serum samples from febrile patients and its co-occurrence with malaria in six districts highly endemic for malaria in Mozambique between 2017 – 2018

Surveillance for arboviruses and leptospirosis among non-malarial acute febrile illness outpatients in areas affected by Cyclones Idai and Kenneth in Mozambique

A historical perspective on arboviruses of public health interest in Southern Africa

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