Retrospective multi-institutional study of radiotherapy for intracranial non-germinomatous germ cell tumors

Aoyama, Hidefumi; Shirato, Hiroki; Yoshida, Hiroshi; Hareyama, Masato; Nishio, Makoto; Yanagisawa, Toru; Kakuto, Yoshihisa; Watarai, Jiro; Inakoshi, Hideki; Miyasaka, Kazuo

doi:10.1016/s0167-8140(98)00081-4

Cited by 34 publications

(17 citation statements)

References 16 publications

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“…The analysis done by Aoyama et al [8] regarding the clinical treatment effects on 24 cases of intracranial teratoma indicates that the survival rate of 5 immature teratoma cases was a mere 44%. As to the analysis of 111 GCT performed by Sawamura et al [9], the 5-year survival rate of 9 cases turned out to be 67%.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of Intracranial Immature Teratoma

Huang

Zhang

Zhou³

2009

Pediatr Neurosurg

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Objective: The purpose of this paper is toexplore the clinical features, treatment and prognosis of intracranial immature teratomas. Methods: The clinical data, serum levels of tumor markers, treatment regimens and prognosis of 15 patients with intracranial immature teratomas were reviewed retrospectively. Results: In patients whose plasma α-fetoprotein (AFP) and β-human chorionic gonadotropin (β-HCG) were determined, AFP and β-HCG were elevated in 57.1 and 16.7% of the cases, respectively. All patients received surgical treatment. The tumor was totally removed in 12 cases, subtotally in 2, and partially in 1 case. After surgery, of the 15 patients, 9 received radiotherapy, 4 gamma knife surgery and 7 chemotherapy. Thirteen patients were followed up. Compared to the common 5-year survival rate of 40%, in patients who received gamma knife surgery, the 5-year survival rate after surgery was 100%, which is better than the 5-year survival rate of patients who did not receive gamma knife surgery (p = 0.0049). Postoperative radiotherapy and chemical therapy had no significant impact on the 5-year survival rate (p > 0.05). Conclusions: The prognosis of intracranial immature teratomas is poor. The detection of their clinical manifestation, the analysis of imaging features and the serum levels of tumor markers are helpful in diagnosing intracranial teratomas. The total removal of the tumor is important to cure the disease. We did not see a difference in outcome between patients who received postoperative chemotherapy or radiotherapy and those who did not. Regular follow-up MRI examinations are necessary so that the conditions of the patients can be closely monitored. If a patient has residual or recurrent tumor after surgery, gamma knife surgery can be effective.

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Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of Intracranial Immature Teratoma

Huang

Zhang

Zhou³

2009

Pediatr Neurosurg

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“…Relevant data were compiled in a North Japanese multiinstitutional study that included 41 patients with pathologically confirmed germinomas treated with different radiation volumes (23). There were 2 relapses among 23 patients treated with CSI.…”

Section: Discussionmentioning

confidence: 99%

Craniospinal radiation in the treatment of biopsy-proven intracranial germinomas: twenty-five years' experience in a single center

Maity

Shu

Janss

et al. 2004

International Journal of Radiation Oncology*Biology*Physics

108

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“…The 5-year relapse-free survival rate was 44% in disseminated germinoma (Aoyama et al, 1998). Results revealed a 90% relapse-free survival rate at 5 years in patients with localized pure germinoma.…”

Section: Algorithm For Diagnosis and Treatment Of Intracranial Germ Cmentioning

confidence: 88%

“…In series with no prophylactic irradiation of the spine (in which complete staging was not obtained for all patients), reported rates of relapse to the spine have been low: 0-10% (Linstadt et al, 1988;Shibamoto et al, 1988;Brada and Rajan, 1990;Wolden et al, 1995;Shirato et al, 1997;Haas-Kogan et al, 2003;Ogawa et al, 2004). Conversely, where treatment has largely involved the delivery of RT alone with volumes tailored to the gross disease, focal irradiation limited to the tumor bed has been associated with reduced relapsefree survival rates (Wolden et al, 1995;Haddock et al, 1997;Matsutani et al, 1997;Shirato et al, 1997;Aoyama et al, 1998;Shibamoto et al, 2001). In the retrospective series of Shikama et al (2005), local field and/or whole brain irradiation was performed in 114 patients, and CSI in 66.…”

Section: Algorithm For Diagnosis and Treatment Of Intracranial Germ Cmentioning

confidence: 99%

Pineal parenchymal tumors, embryonal tumors, and germ cell tumors

Kortmann¹

2012

Handbook of Clinical Neurology

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Retrospective multi-institutional study of radiotherapy for intracranial non-germinomatous germ cell tumors

Cited by 34 publications

References 16 publications

Diagnosis and Treatment of Intracranial Immature Teratoma

Diagnosis and Treatment of Intracranial Immature Teratoma

Craniospinal radiation in the treatment of biopsy-proven intracranial germinomas: twenty-five years' experience in a single center

Pineal parenchymal tumors, embryonal tumors, and germ cell tumors

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