Retrospective observational analysis of the use of an architecturally unique dermal regeneration template (Derma Pure®) for the treatment of hard‐to‐heal wounds

Kimmel, Howard; Gittleman, Haley

doi:10.1111/iwj.12667

Cited by 12 publications

(15 citation statements)

References 28 publications

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“…History: In 1996, the FDA approved the first product of the company, Integra ® dermal regeneration template, a collagen matrix designed as a skin replacement for the treatment of third-degree burn victims. Integra ® dermal regeneration template was the first product approved with a claim of regeneration of dermal tissue (54).…”

Section: Integra ®mentioning

confidence: 99%

“…The dermal replacement layer is made of a porous matrix of fibers of bovine tendon collagen and glycosaminoglycan that is produced with controlled porosity and defined degradation rate. The epidermal layer is made of a thin silicone layer to control moisture loss from the wound (54).…”

Section: Integra ®mentioning

confidence: 99%

“…• Integra ® Template is applied to the removed wound bed. Fluids invade the matrix within minutes of application, adhering it to the wound (54).…”

Section: Integra ®mentioning

confidence: 99%

“…• Collagen (protein) in the Integra ® template is replaced by collagen organically produced by new dermal skin cells (54).…”

Section: Integra ®mentioning

confidence: 99%

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Repairing Injured Skin: Biologics, Skin Substitutes, and Scaffolds: Review

et al. 2019

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Context: Skin damage is one of the most common injuries that occur daily for millions around the world. Considering this high prevalence, developing new methods of cells and stem cell administration for healing injured skin is necessary. We discuss different new methods of stem cell and cell administration for repairing injured skin, such as skin stem cell gun, scaffolds, hydrogels, and autologous keratinocytes sheets. Evidence Acquisition: Many approaches are available in injured skin healing, such as traditional therapy, transplanting, cell therapy, and stem cell therapy. Skin grafting is still a standard solution to treat patients; however, there are a lot of limitations in this procedure, for example, patients with severe burns have an insufficient skin area for grafting, which is a painful procedure. Results: Although cell therapy approaches dissolve scarring and reduce healing time, considering its high cost, they are not used in everyday society. This article discusses different regenerative dermatology products and compares them with each other. Conclusions: Herein, we introduced several examples of skin cell products in the pharmaceutics market. Although these products are not well known and even some of them didn't reach clinical trials, comparing different kinds of skin engineered products reveals appropriate guidelines for their use and entrance to dermatology market.

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Section: Integra ®mentioning

confidence: 99%

Section: Integra ®mentioning

confidence: 99%

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Repairing Injured Skin: Biologics, Skin Substitutes, and Scaffolds: Review

et al. 2019

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“…Though faced with many challenges including scaling up of the processes, regenerative medicine technologies are expanding and are likely to impact on patients' treatment in future. Several natural ECMs have been approved by the Food and Drug Administration (FDA) for use as therapies for diverse conditions as wound healing and liver regeneration [191][192][193][194][195]. Cells such as fibroblasts and keratinocytes have been utilized together with collagen for the treatment of venous and foot ulcers [196,197].…”

Section: Manufacturing and Regulatory Process Considerationsmentioning

confidence: 99%

Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: Inspiring a new Kind of Medicine

Dzobo¹,

Motaung²,

Adesida³

2019

Preprint

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The promise of regenerative medicine and tissue engineering is founded on the ability to regenerate diseased or damaged tissues and organs into functional tissues and organs or the creation of new tissues and organs altogether. In theory, all damaged and diseased tissues and organs can be regenerated or created using different configurations and combinations of extracellular matrix, cells and inductive biomolecules. Currently, regenerative medicine and tissue engineering can allow the improvement of patients’ quality of life through availing novel treatment options. Tissues and organs have a specific ECM, with specific proteins and factors released by cells residing within the local microenvironment. The coupling of regenerative medicine and tissue engineering field with 3D printing is revolutionizing the treatment of patients in a huge way. 3D bioprinting allows the proper placement of cells and ECMs, allowing the recapitulation of native microenvironments of tissues and organs. 3D bioprinting utilizes different bioinks made up of different formulations of ECM/biomaterials, biomolecules and even cells. The choice of the bioink used during 3D bioprinting is very important as properties such as printability, compatibility and physical strength influence the final construct printed. The extracellular matrix (ECM) provides both physical and mechanical microenvironment needed by cells to survive and proliferate. Decellularized ECM bioink contains biochemical cues from the original native ECM and also the right proportions of ECM proteins. Different techniques and characterization methods are used to derive bioinks from several tissues and organs and to evaluate their quality. This review discusses the uses of decellularized ECM bioinks and argues that they represent the most biomimetic bioinks available. In addition, we briefly discuss some polymer-based bioinks utilized in 3D bioprinting.

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Updates on Recent Clinical Assessment of Commercial Chronic Wound Care Products

Sharma

Zhao

2023

Adv Healthcare Materials

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Impaired wound healing after trauma, disorders, and surgeries impact millions of people globally every year. Dysregulation in orchestrated healing mechanisms and underlying medical complications make chronic wound management extremely challenging. Besides standard‐of‐care treatments including broad spectrum antibiotics and wound‐debridement, novel adjuvant therapies are clinically tested and commercialized. These include topical agents, skin substitutes, growth factor delivery, and stem cell therapies. With a goal to overcome factors playing pivotal role in delayed wound healing, researchers are exploring novel approaches to elicit desirable healing outcomes in chronic wounds. Although recent innovations in wound care products, therapies, and devices are extensively reviewed in past, a comprehensive review summarizing their clinical outcomes is surprisingly lacking. Herein, this work reviews the commercially available wound care products and their performance in clinical trials to provide a statistically comprehensive understanding of their safety and efficacy. The performance and suitability of various commercial wound care platforms, including xenogeneic and allogenic products, wound care devices, and novel biomaterials, are discussed for chronic wounds. The current clinical evaluation will provide a comprehensive understanding of the benefits and drawbacks of the most‐recent approaches and will enable researchers and healthcare providers to develop next‐generation technologies for chronic wound management.

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Retrospective observational analysis of the use of an architecturally unique dermal regeneration template (Derma Pure®) for the treatment of hard‐to‐heal wounds

Cited by 12 publications

References 28 publications

Repairing Injured Skin: Biologics, Skin Substitutes, and Scaffolds: Review

Repairing Injured Skin: Biologics, Skin Substitutes, and Scaffolds: Review

Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: Inspiring a new Kind of Medicine

Updates on Recent Clinical Assessment of Commercial Chronic Wound Care Products

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