Retrospective Single-Arm Cohort Study of Patients with Hepatocellular Adenomas Treated with Percutaneous Thermal Ablation

Abstract

Thermal ablation for the treatment of hepatocellular adenoma had a primary and secondary efficacy of 88 and 100%, respectively. The major complication rate was 4.5%. The clinical efficacy during a median follow-up of 1.7 year was 100%.

Current concepts in ablative procedures for primary benign liver lesions: a step forward to minimize the invasiveness of treatment when deemed necessary

“…Two patients presented with liver cirrhosis related to virus B infection or alcoholic abuse, while no patient had predisposing factors for HCA, such as history of oral contraceptives or steroid therapy. No signs of cirrhosis were reported in other studies [10][11][12][13]. The patients treated in the other series were mostly asymptomatic except for a declared history of HCA-related hemorrhage present only in 11% and 22% of cases [10,12].…”

“…No signs of cirrhosis were reported in other studies [10][11][12][13]. The patients treated in the other series were mostly asymptomatic except for a declared history of HCA-related hemorrhage present only in 11% and 22% of cases [10,12]. The use of oral contraceptives was the main predisposing factor [10][11][12].…”

“…The patients treated in the other series were mostly asymptomatic except for a declared history of HCA-related hemorrhage present only in 11% and 22% of cases [10,12]. The use of oral contraceptives was the main predisposing factor [10][11][12]. The decision to pursue percutaneous ablation therapy was based on a multidisciplinary discussion [12,13], or established considering multiple factors.…”

“…The use of oral contraceptives was the main predisposing factor [10][11][12]. The decision to pursue percutaneous ablation therapy was based on a multidisciplinary discussion [12,13], or established considering multiple factors. Ablation was performed in patients not amenable to surgery in view of comorbidities, location or number of the lesions, or in cases otherwise requiring large liver resections [10,13], owing to an expected lower rate of procedural complications compared with surgery [13].…”

“…Percutaneous radiofrequency (RF) or microwave (MW) ablation were used for all patients under US, CT, or combined guidance. RF or MW ablation (RFA, MWA) time varies among the series, with total procedure times ranging from averages of 3 to 22 min depending on the different series and techniques employed [9][10][11][12]. Van Veddler et al compared the use of a CT-guided percutaneous approach to an open approach in which US-guided RF ablation was combined with resection, strategy applied also in some patients with liver adenomatosis (i.e., ≥ 10 nodules) [10].…”