Retrospective study of human cystic echinococcosis in Italy based on the analysis of hospital discharge records between 2001 and 2012

Brundu, Diego; Piseddu, Toni; Stegel, Giovanni; Masu, Gabriella; Ledda, Salvatore; Masala, Giovanna

doi:10.1016/j.actatropica.2014.08.011

Cited by 70 publications

(59 citation statements)

References 23 publications

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“…For example, in a prospective systematic review on CE risk factors in the Qinghai‐Tibet Plateau (China), a positive linear relationship was reported between prevalence and increasing age . Additionally, in an Italian study based on hospital discharge records, among 10 682 CE patients with age at diagnosis ranging from 1 to 100 years old, only 7% were younger than 30 years old, whereas 57% were aged over 60 years old . Similar results were reported recently in western Spain based on data obtained from the public healthcare system during the period 2000‐2012 …”

Section: Introductionsupporting

confidence: 77%

Ageing impairs parasite‐specific antibody responses in cystic echinococcosis

Mourglia‐Ettlin

Miles

Hernández

et al. 2017

Parasite Immunology

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SummaryHumoral immunity wanes during healthy ageing, increasing susceptibility to infections in the elderly. In this sense, information about parasite infections and human immunosenescence is scarce. Cystic echinococcosis (CE) is an infectious disease caused by the larval stage of the cestode parasite Echinococcus granulosus, whose prevalence in humans shows an increase with host age. Susceptibility to human CE has been associated with humoral immunity to some extent, and, therefore, we have here analysed the influence of host age on the serological profile of young, middle-aged and aged patients. Our results highlighted the detrimental influence of ageing on the intensity and quality of the antiparasite antibody response. Remarkable differences in serological profiles between young and aged individuals were observed. In this sense, through Principal Components Analysis, we identified aged patients as those exhibiting overall less intense antibody responses, mainly in isotypes/subclasses supposed to exert efficient antiparasite activities (eg IgE and IgG1). Thus, these humoral defects could at least partially explain the reported increase in CE prevalence among older individuals, as a weaker immune response in the elderly might facilitate the establishment and maintenance of the parasite infection. Finally, a possible association between agedependent susceptibility to CE and host immunosenescence is discussed.

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Section: Introductionsupporting

confidence: 77%

Ageing impairs parasite‐specific antibody responses in cystic echinococcosis

Mourglia‐Ettlin

Miles

Hernández

et al. 2017

Parasite Immunology

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“…Each case of CE results in a mean of 0.97 DALYs with over 1000 cases per year in both Italy (Brundu et al, 2014) and Spain (Herrador et al, 2016), it can be seen that there will be at least 2000 DALYs per annum due to CE in these two countries. These countries dominate the disease burden of CE in southern Europe simply because of their large size and relatively large numbers of cases of CE.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

“…in the northwest and the northeast of Italy were lower, with a registered incidence of 0.47/10 5 and 0.36/10 5 inhabitants, respectively (Brundu et al, 2014). p1150…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

Global Distribution of Alveolar and Cystic Echinococcosis

Deplazes

Rinaldi

Rojas

et al. 2017

Advances in Parasitology

769

679

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“…As a result, no official data are transmitted to the European Centre for Disease Prevention and Control (ECDC) [17][18][19]. At the national level, a mean of 1,379 (SD: 442.5) yearly hospital discharges with a diagnosis of CE were recorded in 2001-12, with annual incidence estimated to range from 0.18 to 6.78 per 100,000 population [20]. However, reporting based solely on hospital discharge records is inadequate, as the majority of CE cases are diagnosed and managed in an outpatient setting [21], besides the fact that asymptomatic cases can be only diagnosed during screening campaigns.…”

Section: Reporting Systems and Burden Of Cystic Echinococcosis In Itamentioning

confidence: 99%

The Italian registry of cystic echinococcosis (RIEC): the first prospective registry with a European future

et al. 2015

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Cystic echinococcosis (CE), a worldwide zoonosis, is highly endemic in southern and eastern Europe. Its actual prevalence is unknown due to the lack of efficient reporting systems designed to take into account the particular features of the disease. Neglect of CE makes diagnosis and clinical management difficult outside referral centres, with inconsistencies in clinical practice and often unnecessary procedures carried out that have associated risks and costs. The Italian registry of CE (RIEC) is a prospective multicentre registry of CE patients seen from January 2012 in Italian health centres; data are voluntarily submitted to the registry. Its aims are to show the prevalence of CE in Italy, bring the importance of this infection to the attention of health authorities, encourage public health policies towards its control, and stimulate biological, epidemiological and clinical research on CE. From January 2012 to February 2014, a total 346 patients were enrolled in 11 centres, outnumbering national reports of many CE-endemic European countries. We discuss preliminary data and challenges of the RIEC, template for the European registry of CE, which has been implemented within the Seventh Framework Programme project HERACLES (Human cystic Echinococcosis ReseArch in CentraL and Eastern Societies) since September 2014.

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Retrospective study of human cystic echinococcosis in Italy based on the analysis of hospital discharge records between 2001 and 2012

Cited by 70 publications

References 23 publications

Ageing impairs parasite‐specific antibody responses in cystic echinococcosis

Ageing impairs parasite‐specific antibody responses in cystic echinococcosis

Global Distribution of Alveolar and Cystic Echinococcosis

The Italian registry of cystic echinococcosis (RIEC): the first prospective registry with a European future

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