Retrospective study of the aetiopathological diagnosis of pleural or peritoneal effusion exams of dogs and cats

Oliveira, A.D.; Engelmann, Ana Martiele; Jaguezeski, Antonise M.; Silva, Cássia Bagolin da; Barbosa, Nathália Viana; Andrade, Cínthia Melazzo de

doi:10.1007/s00580-021-03280-7

Cited by 4 publications

(7 citation statements)

References 35 publications

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“…Only one cat with FIP was included in the previous derivation cohort [ 6 ], and there were none in the validation cohort [ 7 ]. In some recent studies, however, the prevalence of FIP was very similar to the present report (21/105 [20%] of pleural and peritoneal effusions [ 44 ]; 26/306 [8.5%] of pleural effusions [ 3 ]), making FIP an important differential for body cavity effusions in cats. Effusions caused by FIP are particularly interesting in terms of classification.…”

Section: Discussionsupporting

confidence: 90%

Simplified Light’s Criteria and Acute Phase Proteins Reflect Aetiology of Feline Body Cavity Effusions Better than the Traditional Classification Scheme

Hazuchova

Held

Klemm

et al. 2023

Animals

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The traditional veterinary classification (TVC) of effusions based on cell count and total protein (TP) does not adequately reflect the aetiology. Light’s criteria (LC) (activity of lactate dehydrogenase [LDH] in the effusion [LDHef], effusion/serum LDH ratio [LDHr], effusion/serum TP ratio [TPr]), serum–effusion albumin gradient (ALBg), acute phase proteins (APPs) [serum amyloid A (SAA), α1-acid glycoprotein (AGP), haptoglobin] might aid classification. The aim was to evaluate the utility of these parameters except LDHr in differentiating exudates from transudates. Sixty-five cats with effusions (33 peritoneal, 31 pleural, 1 pericardial), with 18 transudates and 47 exudates based on aetiological classification (AC), were included. The sensitivity, specificity and accuracy of several parameters to identify exudates (based on AC) was assessed. APPs were compared between exudates and transudates based on AC and TVC, with receiver operating characteristics analysis identifying the best APP to recognise exudates. Simplified LC (LDHef, TPr) had an accuracy of 79% and TVC of 48%. ALBg had the highest sensitivity (98%) and LDHef the highest specificity (83%) in identifying exudates in cats. All APPs but effusion SAA could differentiate exudates from transudates based on AC (effusion AGP had the largest area under the curve 0.79) but not TVC. All parameters were better than TVC in identifying exudates. The conformity of APPs with AC but not TVC favours the use of AC to classify effusions.

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Section: Discussionsupporting

confidence: 90%

Simplified Light’s Criteria and Acute Phase Proteins Reflect Aetiology of Feline Body Cavity Effusions Better than the Traditional Classification Scheme

Hazuchova

Held

Klemm

et al. 2023

Animals

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“…The peritoneal effusion of the affected dog may correlate to hypoalbuminemia due to protein-losing nephropathy ( 29 ). The prior reports of RD demonstrated that hypoalbuminemia was one of the main causes of peritoneal effusion in dogs ( 30 ). These observations suggest that the peritoneal effusion often occurs in canine RD.…”

Section: Discussionmentioning

confidence: 99%

Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy

Pluemhathaikij

Chankow

et al. 2022

Front. Vet. Sci.

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A case of renal dysplasia (RD) in the Welsh Corgi dog has been reported. Clinically, the affected 3-month-old, female, Welsh Corgi dog showed unclear symptoms of chronic kidney disease. Grossly, both left and right kidneys revealed cystic hypoplasia. Histologically, the primary lesions included immature or fetal glomeruli/tubules, proliferative arterioles, persistent metanephric ducts, persistent mesenchyme, and atypical tubular epithelium were presented. A group of degenerative and inflammatory lesions consisting of interstitial nephritis, interstitial fibrosis, and mineralization of tubules were found. Immunohistochemically, the epithelial cells of immature (fetal) tubules had BCL-2 labeling whereas CD31 (PECAM-1) was labeled in the endothelial cells of the proliferative arterioles. The immunohistochemical findings were confirmed and consolidated with the routine histopathological findings. This study was the first demonstration of the clinical, histopathological, and immunohistochemical features of RD disease in a Welsh Corgi puppy.

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“…Pleural effusion is a condition in which excessive accumulation of fluid (transudate, exudate, chylous, lymph, or blood) occurs in the pleural space. This intrathoracic accumulation may occur when capillary hydrostatic pressure or permeability is increased, intravascular oncotic pressure is decreased, or lymphatic drainage is impeded [ 1 , 2 ]. Therefore, pleural effusion is not a disease entity in itself, but a sign of an underlying disease [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Canine Leishmaniosis Associated with Acute Pleural Effusion and Sudden Death in a Dog

Brito,

Sousa,

Sampaio

et al. 2024

Veterinary Sciences

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A two-year-old female crossbreed dog, previously a stray with no known owner, was adopted and subsequently spayed. The dog exhibited weight loss over a period of two months and died suddenly during a leashed walk. Upon necropsy, enlargement of the submandibular, prescapular, and popliteal lymph nodes was noted. The intrathoracic cavity contained a substantial volume of yellowish-white fluid. Lymph nodes in the mediastinal and ventral thoracic centers were also enlarged, hemorrhagic, and friable. Microscopic examination revealed significant architectural changes in the lymph nodes, characterized by a pronounced cellular infiltrate consisting of lymphocytes and histiocytes, along with macrophages containing intracytoplasmic Leishmania amastigotes. Immunohistochemical analysis of the lymph nodes confirmed positive staining for Leishmania amastigotes. This case represents the first report of canine leishmaniasis associated with acute pleural effusion and sudden death.

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Retrospective study of the aetiopathological diagnosis of pleural or peritoneal effusion exams of dogs and cats

Cited by 4 publications

References 35 publications

Simplified Light’s Criteria and Acute Phase Proteins Reflect Aetiology of Feline Body Cavity Effusions Better than the Traditional Classification Scheme

Simplified Light’s Criteria and Acute Phase Proteins Reflect Aetiology of Feline Body Cavity Effusions Better than the Traditional Classification Scheme

Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy

Canine Leishmaniosis Associated with Acute Pleural Effusion and Sudden Death in a Dog

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