Revealing the complexity of ultra-soft hydrogel re-swelling inside the brain

Shur, Michael; Akouissi, Outman; Rizzo, Olivier; Colin, Didier; Kolinski, John M.; Lacour, Stéphanie

doi:10.1016/j.biomaterials.2023.122024

Cited by 5 publications

(3 citation statements)

References 55 publications

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“…Hydrophilic polymer coatings or films are a potential way to prevent premature device failure by improving overall biocompatibility. However, issues such as swelling, delamination, and manufacturing scale-up have hampered the effective incorporation of existing coating and film technologies into medical devices (32)(33)(34)(35)(36)(37)(38)(39)(40)(41). Here, we addressed these issues by functionalizing a readily sourced and inexpensive cellulose derivative, HEC, with thioether groups via a one-pot, isothiocyanate-based reaction to generate a new, oxidation-responsive biomaterial, HECMTP.…”

Section: Discussionmentioning

confidence: 99%

“…Hydrophilic polymer coatings implanted in a dehydrated state can swell greater than 3 times in size in vivo, leading to increased compressive tissue damage, increased impedance, coating delamination from the underlying device, and patient discomfort (32)(33)(34). Coatings and films applied as soft, hydrated polymers can also easily delaminate or shear off during implantation, leading to the exposure of the underlying surface of the implant, which can stimulate deleterious FBRs (35). Hydrophilic polymers delaminated from devices also pose an increased embolism risk and can disseminate and deposit at distant tissue sites away from the implant, leading to persistent, non-healing abscesses (36).…”

Section: Introductionmentioning

confidence: 99%

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Thioether-functionalized cellulose for the fabrication of oxidation-responsive biomaterial coatings and films

DuBois,

Herrema,

Simkulet

et al. 2024

Preprint

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Biomaterial coatings and films can prevent premature failure and enhance performance of chronically implanted medical devices. However, current hydrophilic polymer coatings and films have significant drawbacks, including swelling and delamination. To address these issues, we modified hydroxyethyl cellulose with thioether groups to generate an oxidation-responsive polymer, HECMTP. HECMTPreadily dissolves in green solvents and can be fabricated as coatings or films with tunable thicknesses. HECMTPcoatings effectively scavenge hydrogen peroxide, resulting in conversion of thioether groups to sulfoxide groups on the polymer chain. Oxidation-driven, hydrophobic-to-hydrophilic transitions that are isolated to the surface of HECMTPcoatings under physiologically relevant conditions increase wettability, decrease stiffness, and reduce protein adsorption to generate a non-fouling interface with minimal coating delamination or swelling. HECMTPcan be used in diverse optical applications and permits oxidation-responsive, controlled drug release. HECMTPfilms are non-resorbablein vivoand evoke minimal foreign body responses. These results highlight the versatility of HECMTPand support its incorporation into chronically implanted medical devices.TeaserModification of cellulose polymer into a non-resorbable, oxidation-responsive biomaterial affords multi-functional coatings and films.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thioether-functionalized cellulose for the fabrication of oxidation-responsive biomaterial coatings and films

DuBois,

Herrema,

Simkulet

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…[ 2 ] This has been explored in the context of implantable neural probes where the electrodes are coated with a soft hydrogel. [ 3,4 ] Such coatings have the capacity to reduce the mechanical mismatch between soft neural tissues and rigid materials (metals, silicon, or organic conductors) used to construct electrodes. [ 5 ] Hydrogel coatings can improve the electrical properties of the interface by reducing impedance and increasing the charge injection capacity.…”

Section: Introductionmentioning

confidence: 99%

Electrochemically Driven Assembly of Chitosan Hydrogels on PEDOT Surfaces

Da Silva,

Amadou‐Douah,

Koiliari

et al. 2023

Macro Materials & Eng

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Hydrogels are attracting interest in the field of bioelectronics due to their ability to serve as coatings on electrodes, improving the electrochemical interface, addressing the mechanical mismatch, and offering potential for localized drug or cell delivery. Challenges persist in integrating hydrogels with electrodes typically composed of metals and/or organic semiconductors. Here, an electrochemically driven method is introduced for direct growth of chitosan hydrogels onto poly(3,4‐ethylenedioxythiophene) (PEDOT) surfaces. The growth of ionic gelation chitosan is triggered by electrical release of a specific dopant, tripolyphosphate (TPP), from PEDOT. As a result, chitosan hydrogels grow directly from the PEDOT surface and firmly attach to it. Although this process temporarily reduces PEDOT to the benzoid structure, its unique electroactivity allows for reversible conversion to the quinoid structure after chitosan hydrogel assembly. Once assembled, the chitosan hydrogel coating can be further functionalized. The introduction of covalent cross‐links and incorporation of additional interpenetrating polymer networks (IPNs) are explored. Electrochemical characterization reveals that an interface with favorable properties is formed between PEDOT and ionic‐covalent chitosan, functionalized with a PEDOT IPN. The electroactivity of the proposed method surpasses any other PEDOT/chitosan system reported in the literature. These results underscore the potential of this material for bioelectronics applications.

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Thioether‐Functionalized Cellulose for the Fabrication of Oxidation‐Responsive Biomaterial Coatings and Films

DuBois,

Herrema,

Simkulet

et al. 2024

Adv Healthcare Materials

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Biomaterial coatings and films can prevent premature failure and enhance the performance of chronically implanted medical devices. However, current hydrophilic polymer coatings and films have significant drawbacks, including swelling and delamination. To address these issues, hydroxyethyl cellulose is modified with thioether groups to generate an oxidation‐responsive polymer, HECMTP. HECMTP readily dissolves in green solvents and can be fabricated as coatings or films with tunable thicknesses. HECMTP coatings effectively scavenge hydrogen peroxide, resulting in the conversion of thioether groups to sulfoxide groups on the polymer chain. Oxidation‐driven, hydrophobic‐to‐hydrophilic transitions that are isolated to the surface of HECMTP coatings under physiologically relevant conditions increase wettability, decrease stiffness, and reduce protein adsorption to generate a non‐fouling interface with minimal coating delamination or swelling. HECMTP can be used in diverse optical applications and permits oxidation‐responsive, controlled drug release. HECMTP films are non‐resorbable in vivo and evoke minimal foreign body responses. These results highlight the versatility of HECMTP and support its incorporation into chronically implanted medical devices.

show abstract

Revealing the complexity of ultra-soft hydrogel re-swelling inside the brain

Cited by 5 publications

References 55 publications

Thioether-functionalized cellulose for the fabrication of oxidation-responsive biomaterial coatings and films

Thioether-functionalized cellulose for the fabrication of oxidation-responsive biomaterial coatings and films

Electrochemically Driven Assembly of Chitosan Hydrogels on PEDOT Surfaces

Thioether‐Functionalized Cellulose for the Fabrication of Oxidation‐Responsive Biomaterial Coatings and Films

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