Revealing the influence of electron beam melted Ti-6Al-4V scaffolds on osteogenesis of human bone marrow-derived mesenchymal stromal cells

Ødegaard, Kristin Sirnes; Ouyang, Lingzi; Ma, Qianli; Buene, Glenn; Wan, Di; Elverum, Christer W.; Torgersen, Jan; Standal, Therese; Westhrin, Marita

doi:10.1007/s10856-021-06572-0

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…EBM has particular utility in the generation of porous metal scaffolds due to the high efficiency and resolution provided by the electron beam, in addition to preservation of mechanical properties [ 135 , 136 ]. Odegaard et al cultured bone-marrow derived stem cells on EBM-generated titanium-aluminum alloy (Ti6Al4V) scaffold and demonstrated robust osteogenic differentiation, cell viability, and proliferation within the scaffold [ 137 ].…”

Section: Future Directions For Addressing Bone Lossmentioning

confidence: 99%

3D-Printing for Critical Sized Bone Defects: Current Concepts and Future Directions

et al. 2022

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The management and definitive treatment of segmental bone defects in the setting of acute trauma, fracture non-union, revision joint arthroplasty, and tumor surgery are challenging clinical problems with no consistently satisfactory solution. Orthopaedic surgeons are developing novel strategies to treat these problems, including three-dimensional (3D) printing combined with growth factors and/or cells. This article reviews the current strategies for management of segmental bone loss in orthopaedic surgery, including graft selection, bone graft substitutes, and operative techniques. Furthermore, we highlight 3D printing as a technology that may serve a major role in the management of segmental defects. The optimization of a 3D-printed scaffold design through printing technique, material selection, and scaffold geometry, as well as biologic additives to enhance bone regeneration and incorporation could change the treatment paradigm for these difficult bone repair problems.

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Section: Future Directions For Addressing Bone Lossmentioning

confidence: 99%

3D-Printing for Critical Sized Bone Defects: Current Concepts and Future Directions

et al. 2022

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“…Titanium and its alloys have been widely used in orthopedic applications [ 14 , 15 ] for their good mechanical properties and favorable biocompatibility [ 16 ]. Titanium itself is bioinert, and polished or abraded titanium has no tissue-bonding ability.…”

Section: Introductionmentioning

confidence: 99%

Effect of Pore Size of Porous-Structured Titanium Implants on Tendon Ingrowth

Guo

Liu

Bian

et al. 2022

Applied Bionics and Biomechanics

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Purpose. The reconstruction of a tendon insertion on metal prostheses is a challenge in orthopedics. Of the available metal prostheses, porous metal prostheses have been shown to have better biocompatibility for tissue integration. Therefore, this study is aimed at identifying an appropriate porous structure for the reconstruction of a tendon insertion on metal prostheses. Methods. Ti6Al4V specimens with a diamond-like porous structure with triply periodic minimal surface pore sizes of 300, 500, and 700 μm and a porosity of 58% (designated Ti300, Ti500, and Ti700, respectively) were manufactured by selective laser melting and were characterized with micro-CT and scanning electron microscopy for their porosity, pore size, and surface topography. The porous specimens were implanted into the patellar tendon of rabbits. Tendon integration was evaluated after implantation into the tendon at 4, 8, and 12 weeks by histology, and the fixation strength was evaluated with a pull-out test at week 12. Results. The average pore sizes of the Ti300, Ti500, and Ti700 implants were 261, 480, and 668 μm, respectively. The Ti500 and Ti700 implants demonstrated better tissue growth than the Ti300 implant at weeks 4, 8, and 12. At week 12, the histological score of the Ti500 implant was 13.67 ± 0.58 , and it had an area percentage of type I collagen of 63.90 % ± 3.41 % ; both of these results were significantly higher than those for the Ti300 and Ti700 implants. The pull-out load at week 12 was also the highest in the Ti500 group. Conclusion. Ti6Al4V implants with a diamond-like porous structure with triply periodic minimal surface pore size of 500 μm are suitable for tendon integration.

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“…The green line indicates the cross-section imaging plane for (b). The red circle represents the area where the metallic powder is trapped[165].…”

mentioning

confidence: 99%

Structural and Biomedical Properties of Common Additively Manufactured Biomaterials: A Concise Review

Ødegaard

Torgersen

Elverum

2020

Metals

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Biomaterials are in high demand due to the increasing geriatric population and a high prevalence of cardiovascular and orthopedic disorders. The combination of additive manufacturing (AM) and biomaterials is promising, especially towards patient-specific applications. With AM, unique and complex structures can be manufactured. Furthermore, the direct link to computer-aided design and digital scans allows for a direct replicable product. However, the appropriate selection of biomaterials and corresponding AM methods can be challenging but is a key factor for success. This article provides a concise material selection guide for the AM biomedical field. After providing a general description of biomaterial classes—biotolerant, bioinert, bioactive, and biodegradable—we give an overview of common ceramic, polymeric, and metallic biomaterials that can be produced by AM and review their biomedical and mechanical properties. As the field of load-bearing metallic implants experiences rapid growth, we dedicate a large portion of this review to this field and portray interesting future research directions. This article provides a general overview of the field, but it also provides possibilities for deepening the knowledge in specific aspects as it comprises comprehensive tables including materials, applications, AM techniques, and references.

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Revealing the influence of electron beam melted Ti-6Al-4V scaffolds on osteogenesis of human bone marrow-derived mesenchymal stromal cells

Cited by 5 publications

References 38 publications

3D-Printing for Critical Sized Bone Defects: Current Concepts and Future Directions

3D-Printing for Critical Sized Bone Defects: Current Concepts and Future Directions

Effect of Pore Size of Porous-Structured Titanium Implants on Tendon Ingrowth

Structural and Biomedical Properties of Common Additively Manufactured Biomaterials: A Concise Review

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