Revealing the structural chemistry of the group 12 halide coordination compounds with 2,2′-bipyridine and 1,10-phenanthroline

Świątkowski, Marcin; Kruszyński, Rafał

doi:10.1080/00958972.2016.1271982

Cited by 8 publications

(4 citation statements)

References 97 publications

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“…394 °C [ 54 ]) in the case of C4 . The partial removal of zinc content, when the chlorides and bromides are present in the structure, is a known phenomenon [ 55 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

Raducka

Świątkowski

Korona-Głowniak

et al. 2022

IJMS

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Developing new, smart drugs with the anticancer activity is crucial, especially for cancers, which cause the highest mortality in humans. In this paper we describe a series of coordination compounds with the element of health, zinc, and bioactive ligands, benzimidazole derivatives. By way of synthesis we have obtained four compounds named C1, C2, C4 and C4. Analytical analyses (elemental analysis (EA), flame atomic absorption spectrometry (FAAS)), spectroscopic (Fourier transform infrared spectroscopy (FT-IR), mass spectrometry (MS)) and thermogravimetric (TG) methods and the definition of crystal structures were used to explore the nature of bonding and to elucidate the chemical structures. The collected analytical data allowed the determination of the stoichiometry in coordination compounds, thermal stability, crystal structure and way of bonding. The cytotoxicity effect of the new compounds as a potential antitumor agent on the glioblastoma (T98G), neuroblastoma (SK-N-AS) and lung adenocarcinoma (A549) cell lines and human normal skin fibroblasts (CCD-1059Sk) was also determined. Cell viability was determined by the MTT assay. The results obtained confirmed that conversion of ligands into the respective metal complexes significantly improved their anticancer properties. The complexes were screened for antibacterial and antifungal activities. The ADME technique was used to determine the physicochemical and biological properties.

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“…394 °C [ 54 ]) in the case of C4 . The partial removal of zinc content, when the chlorides and bromides are present in the structure, is a known phenomenon [ 55 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

Raducka

Świątkowski

Korona-Głowniak

et al. 2022

IJMS

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“…The d 10 configuration of the Zn II ions means that there is no ligand field stabilization for these compounds, that would favour a particular coordination geometry, so no particular coordination geometry is preferred for these ions. Consequently, an exceptional variety of coordination polyhedra is observed in coordination compounds of these metals and this allows the construction of various unique coordination entities (Swiatkowski & Kruszynski, 2017;Bednarchuk et al, 2016;Zhou et al, 2016;Tang et al, 2016;Wu et al, 2016b;Lu et al, 2016;Krinchampa et al, 2016). The usage of thiocyanate anions as building blocks of coordination moieties (Czakis-Sulikowska & Kaluzna, 1996, 1999; Czakis-Sulikowska et al, Among such ligands, the most suitable are relatively simple organic molecules possessing imine or carbonyl double bonds.…”

Section: Introductionmentioning

confidence: 99%

New fluorescent compounds based on zinc thiocyanate: influence of structure on spectral properties

Świątkowski

Kruszyński

2017

Acta Crystallogr C

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New coordination compounds based on zinc thiocyanate, namely (acetone thiosemicarbazone-κN,S)bis(isothiocyanato-κN)zinc(II) monohydrate, [Zn(NCS)(CHNS)]·HO, (I), and diaquatetrakis(urea-κO)zinc(II) tetrakis(isothiocyanato-κN)zinc(II), [Zn(CHNO)(HO)][Zn(NCS)], (II), were synthesized and studied by UV-Vis, fluorescence and IR spectroscopy. Coordination salt (II) forms a rare system composed of two different coordination units of the same metal and it is the first example of a compound with two completely different zinc coordination units, of which one contains a tetrakis(urea)zinc unit. Both (I) and (II) possess fluorescence properties and produce blue and green emissions, respectively, upon irradiation with violet light. The spectral properties were correlated with the observed molecular and supramolecular structures. The acetone thiosemicarbazone ligand of (I) exhibits (upon coordination) red shifts of bands corresponding to N=C and C=S stretching vibration frequencies, which is not typical for chelating molecules.

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“…For this purpose, we decided to explore Hg 2+ as a suitable candidate having one of the largest ionic radii ( r (2+) = 116 pm) among the transition metals. Surprisingly, supramolecular chemistry of homoleptic mercury complexes HgL 3 2+ with Bipy or Phen ligands is almost unexplored, and only a few examples of Hg(Bipy) 3 2+ or Hg(Phen) 3 2+ have been reported . These complexes can only be obtained from mercury salts with weakly coordinating counterions, such as triflates, perchlorates, or hexafluorosilicates; otherwise, the formation of complexes Hg(Phen/Bipy) n =1,2 X 2 (X = halogen, rodanide, etc.)…”

Section: Resultsmentioning

confidence: 99%

Selective Formation of S₄- and T-Symmetric Supramolecular Tetrahedral Cages and Helicates in Polar Media Assembled via Cooperative Action of Coordination and Hydrogen Bonds

et al. 2020

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We report on the synthesis and self-assembly study of novel supramolecular monomers encompassing quadruple hydrogen-bonding motifs and metal coordinating 2,2'-bipyridine units. When mixed with metal ions such as Fe 2+ or Zn 2+ , the tetrahedron cage complexes are formed in quantitative yields and full diastereoselectivity, even in highly polar acetonitrile or methanol solvents. The symmetry of the complexes obtained has been shown to depend critically on the flexibility of the ligand. Restriction of the rotation of the hydrogen-bonding unit with respect to the metal coordinating site results in a T-symmetric cage, whereas by introducing flexibility either through a methylene linker or rotating benzene ring allows the formation of S 4-symmetric cages with selffilled interior. In addition, the possibility to select between tetrahedral cages or helicates, and to control the dimensions of the aggregate, has been demonstrated with three component assembly using external hydrogen-bonding molecular inserts or by varying the radius of the metal ion (Hg 2+ vs Fe 2+). Self-sorting studies of individual Fe 2+ complexes of with ligands of different sizes revealed their inertness toward ligand scrambling.

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Revealing the structural chemistry of the group 12 halide coordination compounds with 2,2′-bipyridine and 1,10-phenanthroline

Cited by 8 publications

References 97 publications

Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

New fluorescent compounds based on zinc thiocyanate: influence of structure on spectral properties

Selective Formation of S₄- and T-Symmetric Supramolecular Tetrahedral Cages and Helicates in Polar Media Assembled via Cooperative Action of Coordination and Hydrogen Bonds

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Revealing the structural chemistry of the group 12 halide coordination compounds with 2,2′-bipyridine and 1,10-phenanthroline

Cited by 8 publications

References 97 publications

Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

New fluorescent compounds based on zinc thiocyanate: influence of structure on spectral properties

Selective Formation of S4- and T-Symmetric Supramolecular Tetrahedral Cages and Helicates in Polar Media Assembled via Cooperative Action of Coordination and Hydrogen Bonds

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Selective Formation of S₄- and T-Symmetric Supramolecular Tetrahedral Cages and Helicates in Polar Media Assembled via Cooperative Action of Coordination and Hydrogen Bonds