Reversal of age-associated frailty by controlled physical exercise: The pre-clinical and clinical evidences

Arc-Chagnaud, Coralie; Millán, Fernando; Salvador‐Pascual, Andrea; Correas, Ángela G.; Olaso‐González, Gloria; Rosa, Adrián De la; Carretero, Aitor; Gómez-Cabrera, Mari Carmen; Viña, José

doi:10.1016/j.smhs.2019.08.007

Cited by 17 publications

(10 citation statements)

References 57 publications

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“…A few studies on the prevalence of frailty in Thailand reported a range of frailty between 8-22% [15, 16]. Other studies showed the cause of frailty to be based on the interplay of genetic, biological, physical, psychological, social, and environmental factors [8,9,17,18]. Elders with other confounding factors such as dependency, chronic disease or complex medical or psycho-social problems are at increased risk of frailty [19].…”

Section: Introductionmentioning

confidence: 99%

Significant Association between Physical Performance and Inflammatory Biomarkers in Older Adults with Frailty in Rural Thailand

Sadjapong¹,

Yodkeeree²,

Sungkarat³

et al. 2020

TOPHJ

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Background: The etiology of frailty is complex and incompletely understood, and is associated with alterations in the immune system, resulting in chronic low-grade inflammation. However, few studies have explored the inflammatory biomarkers related to physical performance in the elderly. Methods: We evaluated the prevalence of frailty with a cross-sectional study among older adults in rural communities in Thailand (n = 457, mean age of 71.4 ± 5.8 years) with Fried’s frailty phenotype including five criteria: weight loss, exhaustion, slowness, weakness, and inactivity. The association between inflammatory biomarkers (serum interleukin-6, IL-6 and C-reactive protein, CRP levels) and physical performance (grip strength, walk times and VO2Max) was examined in frail participants (n=64). Results: The prevalence of frailty and pre-frailty in this population was 37.4% (95% CI, 32.9-42.0) and 54% (95% CI, 49.4-58.7). Multiple linear regression analysis found that serum IL-6 level was significantly elevated in frail older adults with low grip strength (beta = -0.348, SE= 0.155, p = 0.029). Serum CRP level was also elevated significantly in frail older adults with low grip strength (beta = -0.049, SE= 0.023, p = 0.04) and low VO2Max (beta = -0.047, SE= 0.019, p = 0.016) after adjustment for sex, age, hypertension, diabetes, osteoporosis, heart disease, and BMI. Conclusion: Our findings support a low level of grip strength as predictor of inflammatory biomarkers in older adults with frailty. Primary care practitioners could use frailty indicators and performance combined with serum biomarkers for early health risk detection in older adults.

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Section: Introductionmentioning

confidence: 99%

Significant Association between Physical Performance and Inflammatory Biomarkers in Older Adults with Frailty in Rural Thailand

Sadjapong¹,

Yodkeeree²,

Sungkarat³

et al. 2020

TOPHJ

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“…The implementation of intervention programs in the elderly is not an easy task since it is a very heterogeneous population [ 98 ]. This heterogeneity is the basis of the previously mentioned field of personalized medicine, whose objective is to adapt interventions and treatments individually, considering the patient’s lifestyle [ 99 ].…”

Section: Resultsmentioning

confidence: 99%

Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers

García-Giménez

Mena-Mollá

Tarazona-Santabalbina

et al. 2021

IJERPH

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The main epigenetic features in aging are: reduced bulk levels of core histones, altered pattern of histone post-translational modifications, changes in the pattern of DNA methylation, replacement of canonical histones with histone variants, and altered expression of non-coding RNA. The identification of epigenetic mechanisms may contribute to the early detection of age-associated subclinical changes or deficits at the molecular and/or cellular level, to predict the development of frailty, or even more interestingly, to improve health trajectories in older adults. Frailty reflects a state of increased vulnerability to stressors as a result of decreased physiologic reserves, and even dysregulation of multiple physiologic systems leading to adverse health outcomes for individuals of the same chronological age. A key approach to overcome the challenges of frailty is the development of biomarkers to improve early diagnostic accuracy and to predict trajectories in older individuals. The identification of epigenetic biomarkers of frailty could provide important support for the clinical diagnosis of frailty, or more specifically, to the evaluation of its associated risks. Interventional studies aimed at delaying the onset of frailty and the functional alterations associated with it, would also undoubtedly benefit from the identification of frailty biomarkers. Specific to the article yet reasonably common within the subject discipline.

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“…Pois, o processo de impulsos nervosos enviado pelo SN aos músculos para sua contração, passam por degenerações, levando a uma lentidão na resposta do controle motor e diminuição da força muscular. Deixando comprovado que a realização de EF influenciam diretamente no trabalho do SN (ARC-CHAGNAUD et al, 2019).…”

Section: Exercícios Físicosunclassified

“…Os EF são denominados também por treinamento físico (TF). Esse que é subdivido em TF aeróbico (consumo de oxigênio no músculo) e TF anaeróbico (não usa oxigênio e demanda de força e resistência) (ARC-CHAGNAUD et al, 2019). O TF anaeróbico é baseado em ganho de massa muscular (força) por meio de trabalho com peso e resistência muscular, denominaremos aqui como Treinamento Resistido (TR).…”

Section: Exercícios Físicosunclassified

Estágio E a Formação Docente: A Importância Do Professor De Educação Física Na Educação Infantil

Vieira¹,

Figueiredo²,

Leão³

et al. 2020

A Educação Física Como Área De Investigação Científica

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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Reversal of age-associated frailty by controlled physical exercise: The pre-clinical and clinical evidences

Cited by 17 publications

References 57 publications

Significant Association between Physical Performance and Inflammatory Biomarkers in Older Adults with Frailty in Rural Thailand

Significant Association between Physical Performance and Inflammatory Biomarkers in Older Adults with Frailty in Rural Thailand

Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers

Estágio E a Formação Docente: A Importância Do Professor De Educação Física Na Educação Infantil

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