Reversal of Lead-Induced Oxidative Stress by Chelating Agent, Antioxidant, or Their Combination In the Rat

Environmental lead exposure as a risk for childhood aplastic anemia

“…In this study, TBARS level was significantly higher in aplastic anemia patients. Our finding is further supported by other experimental studies where blood TBARS level was higher due to lead exposure (14,15). Peroxidation of erythrocyte membrane lipids can be very damaging because it leads to alterations in the biological properties of the membrane, such as the degree of fluidity and can result in inactivation of membrane-bound receptors or enzymes, which in turn may impair normal cellular function, increase tissue permeability and shorten the life span of blood cells.…”

“…Free radical generation seems to be the possible mechanism of lead toxicity (14)(15)(16)(17)(18). In the present study we evaluated the effect of blood levels on oxidative stress parameters in children suffering from aplastic anemia disease.…”

Comparative Effect of Silymarin and D-Penicillamine on Lead Induced Hemotoxicity and Oxidative Stress in Rat

“…Blood levels of the antioxidant enzymes SOD and catalase (CAT) has been elevated or suppressed by lead depending mainly on the level and duration of exposure. Higher levels of exposure to Pb in experimental or cross-Volume 11, No 3, May-June2017; http://www.ijt.ir sectional studies are reported to cause increases in the activity of these enzymes as a consequence of elevated reactive oxygen species production [3,[31][32]. However, the activities of GPx, CAT and SOD as major antioxidant enzymes in the erythrocytes significantly crashed usually at chronic exposure with lower amounts of lead [33].…”

ALAD (δ-aminolevulinic Acid Dehydratase) as Biosensor for Pb Contamination

“…δ-ALAD is a sulfhydryl containing enzyme (Gibson et al 1955, Barnard et al 1977 and numerous metals such as lead (Rodrigues et al 1989, and Goering 1993, mercury (Rocha et al, 1993(Rocha et al, , 1995, and other compounds that oxidize sulfhydryl groups modified its activity (Emanuelli et al 1996, Barbosa et al 1998, Flora et al 1998). Therefore, δ-ALAD is inhibited by substances that compete with zinc and/or that oxidize the -SH groups (Farina et al 2002, Nogueira et al 2003a-b, Santos et al 2004 and is linked to situations associated with oxidative stress , Pande et al 2001, Pande & Flora 2002, Tandon et al 2002, Soares et al 2003. In addition, human exposure to Pb 2+ causes an important inhibition of blood δ-ALAD (Meredith et al 1979, Fujita et al 1981, Pappas et al 1995, Polo et al 1995, Pires et al 2002 and is associated with an intense anemia accompanied by an increase in urinary δ-ALA excretion (Oskarsson 1989).…”