Reversal of LPS‐induced central and peripheral hyperalgesia by green tea extract

Abstract

Tea has recently attracted a great deal of attention for its beneficial health effects. Green tea polyphenols inhibit the production of arachidonic acid metabolites and leukotrienes resulting in decreased inflammatory responses. In the present study, the effect of green tea extract (GTE) on lipopolysaccharide (LPS)-induced thermal and behavioural hyperalgesia in mice and the possible involvement of the cyclooxygenase pathway in this paradigm was evaluated. GTE (25 mg/kg, i.p.), nimesulide (2 mg/kg, i.p.) and rofecoxib (2 mg/kg, i.p.) significantly attenuated LPS-induced thermal and behavioural hyperalgesia but per se did not modify any of the behavioural effects. Concurrent administration of a subeffective dose of GTE (10 mg/kg, i.p.) and rofecoxib (2 mg/kg, i.p.) or nimesulide (2 mg/kg, i.p.) significantly potentiated the antinociceptive effect of GTE in both LPS-induced thermal and behavioural hyperalgesia with nimesulide showing a more pronounced enhancing effect. Thus it can be concluded that GTE attenuates LPS-induced central and peripheral hyperalgesia by selective inhibition of cyclooxygenase-2 enzyme.

Protective Effect of Epigallocatechin Gallate in Murine Water‐Immersion Stress Model of Chronic Fatigue Syndrome

“…[40] suggested that EGCG exerts anxiolytic effect by interacting with GABA receptors, and Kaur et al. [28] also found that green tea extract attenuates LPS‐induced central and peripheral hyperalgesia by selective inhibition of cyclooxygenase‐2 enzyme. In our study, we also found a significant impairment in memory of fatigued mice in elevated plus maze and this finding is supported by the results of Haiq‐Ferquson et al.…”

Modulation of antigen‐induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant

“…Stress‐induced hyperalgesia was assessed by tail‐immersion test. Mice were held individually and their tails were immersed in hot water (52.5 ± 0.5 °C) for not more than 10 s as cut off time, and withdrawal latency was observed on the same days as the immobility was observed [21].…”

Effects of (−)-Gallocatechin-3-Gallate on Tetrodotoxin-Resistant Voltage-Gated Sodium Channels in Rat Dorsal Root Ganglion Neurons

“…Studies have demonstrated an antinociceptive effect of green tea extract on inflammatory and neuropathic pain [1,2]. (−)-Epigallocatechin-3-gallate (EGCG) is one of the major catechins of green tea leaves and it has been shown to exhibit analgesic efficacy.…”