2011
DOI: 10.1016/j.atherosclerosis.2011.02.013
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Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: A randomized controlled trial

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Cited by 93 publications
(87 citation statements)
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“…17 Ubiquinol supplementation did not affect LDL-lowering effect of simvastatin and attenuated lactate/pyruvate ratio elevation, possibly from an improvement in mitochondrial function. This finding is similar to a recent study 18 and is in agreement with our previous in-vitro data showing Q10 supplementation in Circulating ALT and ALP were reduced significantly in Group 2, suggesting potential benefits of ubiquinol at molecular level although its clinical significance is uncertain. In a previous clinical trial, 17 plasma ALT and AST were not significantly different in CoQ10 supplemented group from patients treated with atorvastatin.…”
Section: Discussionsupporting
confidence: 83%
“…17 Ubiquinol supplementation did not affect LDL-lowering effect of simvastatin and attenuated lactate/pyruvate ratio elevation, possibly from an improvement in mitochondrial function. This finding is similar to a recent study 18 and is in agreement with our previous in-vitro data showing Q10 supplementation in Circulating ALT and ALP were reduced significantly in Group 2, suggesting potential benefits of ubiquinol at molecular level although its clinical significance is uncertain. In a previous clinical trial, 17 plasma ALT and AST were not significantly different in CoQ10 supplemented group from patients treated with atorvastatin.…”
Section: Discussionsupporting
confidence: 83%
“…[11][12][13][14][15][16] In addition, several lines of evidence have shown that FMD is an independent predictor of future cardiovascular events. [17][18][19][20][21][22] Nitroglycerine-induced vasodilation, an index of endothelium-independent vasodilation, assessed by sublingual administration of nitroglycerine has been used as a control test for FMD measurement to differentiate endothelium-dependent vasodilation from endothelium-independent vasodilation because both endogenous nitric oxide and administered nitroglycerine act on vascular smooth muscle cells.…”
mentioning
confidence: 99%
“…[3][4][5][6][7][8][9][10] Appropriate interventions, including pharmacological therapy, supplementation therapy, and lifestyle modifications, are effective for improving endothelial function assessed by FMD in patients with cardiovascular diseases. [11][12][13][14][15][16] In addition, several lines of evidence have shown that FMD is an independent predictor of future cardiovascular events.…”
mentioning
confidence: 99%
“…However, clinical trials that investigated the ability of coenzyme Q10 [29,30], NADH (reduced nicotinamide adenine dinucleotide) [31,32], and alpha-lipoic acid [33] to improve mitochondrial function have not shown consistent results. L-carnitine is a critical component for mitochondrial fatty acid oxidation, and its supplementation has been shown to improve quality of life and reduce fatigue-related symptoms in patients with chronic kidney disease, cancer, and chronic hepatitis [26,[34][35][36].…”
Section: Discussionmentioning
confidence: 99%