Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740

Adrenomedullin regulates intestinal physiology and pathophysiology

“…The effects were significant in females but not males, indicating a gender bias [202]. This pattern of sex-specific differences has been already described in other KO models, such as NO synthase KO mice [206], in atrial natriuretic peptide gene-disrupted mice [207], or GluA1 KO mice [208], among others.…”

Maternal lipopolysaccharide treatment differentially affects 5-HT2A and mGlu2/3 receptor function in the adult male and female rat offspring

“…For example, the mGlu2/3 receptor agonist LY354740 has been shown to reduce novelty-induced hyperlocomotion and hippocampal c-Fos protein expression in GluA1 receptor knockout male but not in female mice (Procaccini et al, 2013). Moreover, although prenatal stress resulted in a similar reduction of mGlu2/3 receptor IR within the hippocampus of adult male and female offspring, there were clear sex differences regarding anxiety-related behaviors in the elevated plus-maze (Zuena et al, 2008).…”

Reversal of novelty-induced hippocampal c-Fos expression in GluA1 subunit-deficient mice by chronic treatment targeting glutamatergic transmission

“…The metabotropic mGluR2/3 agonist (1S,2S,5R,6S)-2-aminobicyclo [3.1.0]hexane-2,6-dicarboxylic acid (LY354740) suppresses the novelty reaction behaviourally and attenuates excessive dorsal hippocampal activity induced by environmental exploration in Gria1À/À mice (Procaccini et al, 2011(Procaccini et al, , 2013. Chronic lithium, valproate, topiramate and lamotrigine also attenuate the locomotor hyperactivity of the Gria1À /À mice (Maksimovic et al, 2014).…”