Reversal of prenatal diazepam-induced deficit in a spatial-object learning task by brief, periodic maternal separation in adult rats

Early life manipulations alter learning and memory in rats

“…The “can” test (CT) was developed by Cannizzaro and colleagues (Cannizzaro et al, 2005; Cannizzaro et al, 2006) to test place or object memory without the use of aversive stimuli. Instead, cues are paired with the presence of a reward (Popvic et al, 2001).…”

“…Much like RAM, specific cans are baited during training and latency, correct responses, and errors measured to assess working and reference memory during test sessions. Brief isolation throughout the post-weaning period enhanced reference and working memory in adult rats (Cannizzaro et al, 2006) whereas only working memory was enhanced in aged rats (Cannizzaro et al, 2005). CT results are consistent with RAM data in that a brief manipulation decreases working memory errors in aged, male rats.…”

“…There were 21 studies reported upon in the papers in this review that assessed anxiety in EPM (Table 6). Five EPM studies utilized brief manipulations and all but one (Cannizzaro et al, 2005) reports it decreased anxiety (Cannizzaro et al, 2005; Meerlo et al, 1999; Nunez et al, 1995; Vallee et al, 1997). Only one study, using a prolonged manipulation, reports decreased anxiety (Catalani et al, 2000) whereas, three report increased anxiety (Aisa et al, 2007; Imanaka et al, 2006; Wigger and Neumann, 1999).…”

“…Of the 14 OF studies in rats with brief manipulations, five studies report increased activity or time in the center (Cannizzaro et al, 2005; Madruga et al, 2006; Nunez et al, 1996; Nunez et al, 1995; Pham et al, 1997) whereas the other nine studies report non-significant findings (Gibb and Kolb, 2005; Meerlo et al, 1999; Nunez et al, 1996; Powell and North-Jones, 1974; Solas et al, 2010; Stevenson et al, 2009; Vallee et al, 1997) as seen in Table 6. Fourteen studies examined OF in rats with prolonged manipulations and most report no effect (Aisa et al, 2007; Garner et al, 2007; Imanaka et al, 2006; Kosten et al, 2005; Lehmann et al, 1999; Madruga et al, 2006; Stevenson et al, 2009).…”

Erken Yavru Kayıplarının Sıçanlardaki Annelik Davranışına ve Sonraki Yavrulara Etkileri: Bebek Kaybının Hayvan Çalışması Modeli

“…Data from numerous research applying maternal separation procedure have shown that a sequence of behavioral and physiological changes occurs in the pups when they were separated from the dam. While some researchers point to beneficial effects of brief periodic maternal separation on cognitive development of the offspring, most underline the <adverse effects (15). Immediate initiation of ultrasonic vocalizations, marked inhibition of the growth hormone (GH) and of the enzyme ornithine decarboxylase (ODC), an important mediator of nucleic acid synthesis, have been observed.…”