Reversal of Primary Root Caries Using a Dentifrice with a High Fluoride Content

Lynch, Edward; Baysan, Aylin

doi:10.1159/000049113

Cited by 60 publications

(46 citation statements)

References 18 publications

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“…The preservation and stability of dentin collagen may be essential during the re-mineralization process since it acts as a scaffold for mineral deposition 6) . Preservation of collagen matrix would be followed by promotion of remineralization of demineralized dentin, which is one of the important strategies regarding preventive therapies for root caries [7][8][9][10] . In an attempt to stabilize the collagen matrix, glutaraldehyde and some natural flavonoids such as grape seed extract (GSE) have been used on root caries to investigate their cross-linking effects on demineralized lesion 11,12) .…”

Section: Intorductionmentioning

confidence: 99%

<I>In vitro</I> effect of hesperidin on root dentin collagen and de/re-mineralization

et al. 2012

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The aims of this study were to investigate the effects of hesperidin, a citrus flavonoid, on human root dentin demineralization and collagen preservation, and compare it with chlorhexidine and grape seed extract. Specimens were assigned to different treatment groups: hesperidin, chlorhexidine and grape seed extract. Specimens were subjected to pH cycling by demineralization for 14 h, incubation in testing solutions for 2 h and remineralization in presence of bacterial-derived collagenase for 8 h, for 8 days. Calcium release was measured by means of an atomic absorption spectrophotometer, and degraded collagen matrix was investigated by hydroxyproline assay. Specimens were assessed longitudinally with transverse micro-radiography to investigate lesion depth and mineral loss. In hesperidin and grape seed extract groups, demineralization was reduced when the collagen matrix was preserved. The hesperidin group showed the lowest value in lesion depth and mineral loss, indicating that hesperidin inhibited demineralization and probably enhanced remineralization even under fluoride-free conditions.

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Section: Intorductionmentioning

confidence: 99%

<I>In vitro</I> effect of hesperidin on root dentin collagen and de/re-mineralization

et al. 2012

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“…Therefore, preventive measures are highly emphasized, and it is recommended that these measures should be taken immediately after exposure of root surfaces considering that lesion progression in roots is faster than that in enamel because of their relatively low mineral content 7,8) . Fluoride, which can interfere the physicochemical 9) and microbiological 10) processes of root caries initiation/development, is widely accepted as an effective preventative agent 11) , and fluoride-containing mouthrinses, toothpastes and topical varnishes are recommended by clinicians as a prophylactic program to high-risk populations [12][13][14][15] . However, the effects of these preventative strategies are only temporary and successful prevention of root surface caries is usually hampered by the low compliance of the patients.…”

Section: Introductionmentioning

confidence: 99%

Effects of a coating resin containing S-PRG filler to prevent demineralization of root surfaces

Imazato

Chen

et al. 2012

Dent. Mater. J.

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The purpose of this study was to evaluate the ability of a coating material containing the surface pre-reacted glass-ionomer (S-PRG) filler to protect the root from demineralization in vitro. The proprietary coating resin containing the S-PRG filler (PRG Barrier Coat) was applied to human root dentin and immersed in acid buffer at pH 4.5 for 3 d. Demineralization was evaluated by micro-CT scanning and the dentin-material interface observed by scanning electron microscopy. The ability of the coating resin to modify acid production by Streptococcus mutans was investigated by monitoring pH using an ion-sensitive field-effect transistor pH electrode. Application of PRG Barrier Coat produced a coating layer with the thickness of approximately 200 µm and completely inhibited demineralization. The bacteria-induced pH fall at the material surface was significantly inhibited. We conclude that S-PRG fillercontaining coating resin may be an effective material for protecting exposed root from both chemical and biological challenges. Keywords: Resin coating, Root caries, Demineralization, S-PRGThe second and third authors contributed equally to this work.

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“…Highly concentrated fluoride toothpaste seems to have a beneficial effect on the rehardening of root caries [Lynch and Baysan, 2001]. However, patients often demonstrate poor compliance with these regimens [Horiot et al, 1983;Epstein et al, 1996].…”

mentioning

confidence: 99%

Saliva Substitutes in Combination with Highly Concentrated Fluorides and Brushing: In vitro Effects on Enamel Subsurface Lesions

Tschoppe

Siegel²,

Meyer-Lueckel³

2010

Caries Res

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Hyposalivation is often associated with high caries activity, in particular in patients undergoing irradiation in the head/neck area. Besides the use of saliva substitutes to relieve the oral symptoms, daily application of fluoride gels or toothpaste (5,000 µg F^–/g) is recommended for caries prevention. The aim of this study was to evaluate potentially remineralising effects of these fluoride agents in combination with saliva substitutes on enamel subsurface lesions. Demineralised bovine specimens were either stored in mineral water [control; saturation with respect to octacalcium phosphate (S_OCP): 0.8], a demineralising saliva substitute (Glandosane; S_OCP: 0.3) or in a modified (with respect to S_OCP) saliva substitute [Saliva natura (SN); S_OCP: 1.9] for 5 weeks (37°C). The following treatments were applied twice daily (11–13/group): no treatment (0), ProSchmelz fluoride gel (PS; 10 min application), Duraphat toothpaste (DP; 10 s; brushing with toothpaste/storage solution slurry), combination of DP+PS. Mineral parameters before/after storage were evaluated from microradiographs. Storage in Glandosane led to significant demineralisation (p < 0.05; paired t test), whereas additional use of fluoride agents neutralised the demineralising effect (p > 0.05). Storage in water alone resulted in no changes in mineral parameters (p > 0.05), whereas in combination with fluorides remineralisation could be shown (p < 0.05). For SN alone, remineralisation was observed (p < 0.05), but no additional beneficial effects of fluorides were detected. Under the conditions chosen, the fluoride agents reduce the demineralising effects of Glandosane and promote the remineralisation of specimens stored in water. Remineralising effects of SN could not be enhanced by the fluorides.

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Reversal of Primary Root Caries Using a Dentifrice with a High Fluoride Content

Cited by 60 publications

References 18 publications

<I>In vitro</I> effect of hesperidin on root dentin collagen and de/re-mineralization

<I>In vitro</I> effect of hesperidin on root dentin collagen and de/re-mineralization

Effects of a coating resin containing S-PRG filler to prevent demineralization of root surfaces

Saliva Substitutes in Combination with Highly Concentrated Fluorides and Brushing: In vitro Effects on Enamel Subsurface Lesions

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