Reversal of retinal pigment epithelial detachment after cessation of topical travoprost therapy

Kalikivayi, Venkataramana; Joseph, Jerry; Mathews, Blessy Thankom; Maheswari, Rajkumar; Vadakara, Satyajit Mulanjur; Jacob, Sajeev Cherian

doi:10.1007/s10792-017-0711-3

Cited by 4 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 8 – 10 Travoprost has been associated with NSD only in a single case report and the edema resolved on stopping the presumed offending drug. 11 Macular edema along with NSD has been reported concurrently in only two patients on topical Latanoprost therapy but both of these patients had undergone complicated cataract surgeries and the presence of edema could have been attributed to this risk factor. 8 , 9 Since our patient had uncontrolled IOP on maximum therapy, we could not stop eye drop Travoprost despite the rare association of NSD with Travoprost.…”

Section: Discussionmentioning

confidence: 99%

Iridocorneal Endothelial Syndrome with Coexisting Macular Edema and Neurosensory Detachment: An Unusual Case Report

Singh¹,

Dubey²,

Jain³

et al. 2022

Journal of Current Glaucoma Practice

View full text Add to dashboard Cite

A bstract The iridocorneal endothelial (ICE) syndrome is a sporadic, unilateral condition characterized by abnormalities of the cornea, anterior chamber angle, and iris affecting middle-aged women (3rd to 5th decade). It consists of three variants: progressive iris atrophy, Cogan–Reese syndrome—diffuse nevus or iris nodules, and Chandler syndrome—corneal endothelial abnormalities leading to corneal edema. This syndrome has an abnormal corneal endothelial cell layer (proliferative endotheliopathy), which migrates across the angle and onto the surface of the iris. It is a potentially blinding condition as a result of secondary glaucoma and/or corneal decompensation. Although few case reports have shown an association of ICE syndrome with macular edema; however, our case was unique in the sense that it was associated with neurosensory detachment (NSD). It can be suggested that PG analogs are not a good idea to be prescribed for secondary glaucoma management in patients with ICE syndrome as it can predispose to the development of macular edema with NSD. How to cite this article: Dubey S, Jain K, Singh S, et al. Iridocorneal Endothelial Syndrome with Coexisting Macular Edema and Neurosensory Detachment: An Unusual Case Report. J Curr Glaucoma Pract 2021;15(3):149–152.

show abstract

Section: Discussionmentioning

confidence: 99%

Iridocorneal Endothelial Syndrome with Coexisting Macular Edema and Neurosensory Detachment: An Unusual Case Report

Singh¹,

Dubey²,

Jain³

et al. 2022

Journal of Current Glaucoma Practice

View full text Add to dashboard Cite

show abstract

“…Less commonly reported side effects include iris cysts, cystoid macular edema, anterior uveitis, and reactivation of herpes simplex keratitis [6]. Retinal pigment epithelial layer detachment has also been reported [7]. Other side effects include eyelid darkening, eyelash hypertrichosis, and deepening of the superior sulcus of the eyelid [8].…”

Section: Introductionmentioning

confidence: 99%

Headache associated with travoprost

Jacob,

Kalyan,

Kalikivayi

et al. 2023

Med Hypothesis Discov Innov Optom

View full text Add to dashboard Cite

Background: Putative adverse effects of prostaglandin analogs in patients treated for glaucoma include periocular skin darkening, herpes simplex keratitis, cystoid macular edema, iritis, and headaches. Here, we report a case of migraine headache after a travoprost administration and discuss the role of prostaglandin analogs in migraine-like headaches. Case Presentation: A 70-year-old man visited the hospital complaining of pain, redness, and sensitivity to light for 1 week associated with gradual loss of vision in the right eye after cataract surgery, which had been performed 2 years prior. After the examination, the patient was diagnosed with pseudophakic bullous keratopathy and advised to undergo optical penetrating keratoplasty of the right eye. On postoperative day 3, his intraocular pressure (IOP) was 30 mmHg at 10:00 AM in the right eye. A single dose of 0.004% travoprost was instilled in the right eye on the same day. His IOP decreased to 16 mmHg at 2:00 PM. The next day, he presented with migraine-like headache that had started within 1 h after the instillation the previous night. Unremarkable neurological examination and neuroimaging suggested that travoprost had caused the migraine. Although the headache gradually resolved, it reappeared after the administration of other prostaglandins. Trabeculectomy was performed on the right side. The IOP was controlled, and the headache was resolved. Conclusions: This case indicates a potential causal relationship between topical prostaglandin analogs and migraine-like headaches, as evidenced by symptom resolution upon discontinuation. However, large-scale studies including control groups are required to prove a causal relationship between topical prostaglandin analog administrations and headache development.

show abstract

“…There is also a single report on subtotal uveal effusions in a patient with Sturge-Weber Syndrome 1 week after commencing a combination of travoprost 0.004% and timolol 0.5% 4. A further case describes retinal pigment epithelial detachment without SMD in the context of travoprost 0.004% therapy 5…”

Section: Introductionmentioning

confidence: 99%

Serous macular detachments associated with topical travoprost

Patheja

2022

BMJ Case Rep

View full text Add to dashboard Cite

Here is presented a unique case of bilateral serous macular detachments as a side effect of topical travoprost (0.004%) therapy. Only three other cases in the literature have definitively associated this side effect with other topical prostaglandins. The aetiological and pathophysiological pathways remain to be clearly elucidated but are potentially related to increased choroidal vascular permeability. In this case, the subretinal fluid resolved rapidly and completely after cessation of travoprost drops, showing it to be a reversible pathology similar to prostaglandin-associated cystoid macular oedema. This uncommon association is therefore important to consider in the differential diagnosis of serous macular detachment. Increasing ophthalmic awareness could help to prevent unnecessary investigations in undifferentiated patients without other guiding historical or examination features. This may save time and expense for the patient and health systems.

show abstract

Reversal of retinal pigment epithelial detachment after cessation of topical travoprost therapy

Abstract: Hence, clinicians should be aware of this rare incidence of RPED followed by travoprost therapy. First case of RPED following travoprost therapy and complete reattachment upon withdrawal is reported here in this case report.

Cited by 4 publications

References 11 publications

Iridocorneal Endothelial Syndrome with Coexisting Macular Edema and Neurosensory Detachment: An Unusual Case Report

Iridocorneal Endothelial Syndrome with Coexisting Macular Edema and Neurosensory Detachment: An Unusual Case Report

Headache associated with travoprost

Serous macular detachments associated with topical travoprost

Contact Info

Product

Resources

About