Reversal of the Immunosuppressive Effect of L-Asparaginase by L-Glutamine

BenEzra, David; Pitaro, R.; Birkenfeld, V.; Hochman, A

doi:10.1038/newbio236080a0

Cited by 12 publications

(2 citation statements)

References 4 publications

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“…Notably, treatment with ASN also causes immunosuppression, which is likely due to the inhibition of both T-and B-cell-mediated immune responses (84)(85)(86)(87). However, the immunosuppressive properties of ASN are largely due to its glutamine depletion activity in vitro and in vivo (88)(89)(90)(91)(92). Consistent with these studies, the acute treatment of a glutamine antagonist, 6-Diazo-5-oxo-L-norleucine (DON), suppresses T-cell proliferation in vitro and in mice (4) ( Fig.…”

Section: Glutamine and Other Amino Acidsmentioning

confidence: 99%

Metabolic reprogramming and metabolic dependency in T cells

Wang

Green

2012

Immunological Reviews

160

144

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Summary Upon activation, quiescent naive T cells undergo a growth phase followed by massive clonal expansion and differentiation that are essential for appropriate immune defense and regulation. Accumulation of cell biomass during the initial growth and rapid proliferation during the expansion phase is associated with dramatically increased bioenergetic and biosynthetic demands. This not only requires a metabolic rewiring during the transition between resting and activation, but also ‘addicts’ active T cells to certain metabolic pathways in ways that naive and memory T cells are not. We consider such addiction in terms of the biological effects of deprivation of metabolic substrates or inhibition of specific pathways in T cells. In this review, we illustrate the relevant metabolic pathways revealed by recent metabolic flux analysis and discuss the consequences of metabolic intervention on specific metabolic pathways in T lymphocytes.

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Section: Glutamine and Other Amino Acidsmentioning

confidence: 99%

Metabolic reprogramming and metabolic dependency in T cells

Wang

Green

2012

Immunological Reviews

160

144

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“…The foregoing considerations lead to the hypothesis that direct contact of contaminant glutaminase (Benezra et al, 1972) and that glutamine depletion is of more significance than asparagine depletion, but this does not affect the basic arguments (Simberkoff and Thomas, 1970).…”

Section: Discussionmentioning

confidence: 99%

Extracorporeal chemotherapy with L‐asparaginase in man

Sampson¹,

Han²,

Hersh

et al. 1974

Journal of Surgical Oncology

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An extracorporeal chemotherapy unit has been used in baboons and man. Blood was perfused over plates coated with L‐asparaginase in 4 hour perfusion studies. It was possible to lower serum asparagine levels almost to zero, and to render both human and animal lymphocytes unreactive to mitogenic stimulation. The toxicity associated with L‐asparaginase was avoided and the potential application of this technique to the treatment of human lymphatic leukemia is discussed.

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Comparison of the immunodepressant action of microbial deaminase from different sources

Козлов¹,

Tsvetkova²

1984

Bull Exp Biol Med

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Reversal of the Immunosuppressive Effect of L-Asparaginase by L-Glutamine

Cited by 12 publications

References 4 publications

Metabolic reprogramming and metabolic dependency in T cells

Metabolic reprogramming and metabolic dependency in T cells

Extracorporeal chemotherapy with L‐asparaginase in man

Comparison of the immunodepressant action of microbial deaminase from different sources

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