Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation

Joseph, James A.; Shukitt‐Hale, Barbara; Denisova, Natalia A.; Bielinski, Donna F.; Martín, António; McEwen, John J.; Bickford, Paula C.

doi:10.1523/jneurosci.19-18-08114.1999

Cited by 857 publications

(645 citation statements)

References 72 publications

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“…These results show that coffee, in easily achievable amounts, may reduce both motor and cognitive deficits in aging, similar to prior studies with berries (Joseph et al 1999;Youdim et Joseph et al 1999). Furthermore, the neuroprotective benefits seen with coffee in these studies appear to be not due to caffeine alone but instead to the polyphenols and other bioactive compounds in coffee.…”

Section: Discussionsupporting

confidence: 86%

“…A battery of age-and diet-sensitive tests of psychomotor behavior (Joseph et al 1983;Shukitt-Hale et al 1998;Joseph et al 1999;Youdim et al 2000;Shukitt-Hale et al 2005;Ingram et al 1994) was administered in a random order to the animals during week 6 of treatment. Each test was performed once, separated by a break between tasks.…”

Section: Psychomotor Testsmentioning

confidence: 99%

“…The MWM, an accepted method for testing spatial learning and memory, is an age- (Ingram et al 1994;Brandeis et al 1989;Shukitt-Hale et al 1998) and diet-sensitive (Joseph et al 1999;Youdim et al 2000;Shukitt-Hale et al 2005;Shukitt-Hale et al 2009a) learning paradigm that requires the rat to use spatial cues to find a hidden platform (10 cm in diameter) submerged 2 cm below the surface of the water in a circular pool (134 cm in diameter×50 cm in height; maintained at 23°C) and remember its location from the previous trial. Accurate navigation is rewarded with escape from the water onto the platform, which the rat uses distal and spatial cues to efficiently locate.…”

Section: Cognitive Testingmentioning

confidence: 99%

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Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging

Shukitt‐Hale

Miller

Chu

et al. 2013

AGE

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The complex mixture of phytochemicals in fruits and vegetables provides protective health benefits, mainly through additive and/or synergistic effects. The presence of several bioactive compounds, such as polyphenols and caffeine, implicates coffee as a potential nutritional therapeutic in aging. Moderate (three to five cups a day) coffee consumption in humans is associated with a significant decrease in the risk of developing certain chronic diseases. However, the ability of coffee supplementation to improve cognitive function in aged individuals and the effect of the individual components in coffee, such as caffeine, have not been fully evaluated. We fed aged rats (19 months) one of five coffeesupplemented diets (0, 0.165, 0.275, 0.55, and 0.825 % of the diet) for 8 weeks prior to motor and cognitive behavior assessment. Aged rats supplemented with a 0.55 % coffee diet, equivalent to ten cups of coffee, performed better in psychomotor testing (rotarod) and in a working memory task (Morris water maze) compared to aged rats fed a control diet. A diet with 0.55 % coffee appeared to be optimal. The 0.165 % coffeesupplemented group (three cups) showed some improvement in reference memory performance in the Morris water maze. In a subsequent study, the effects of caffeine alone did not account for the performance improvements, showing that the neuroprotective benefits of coffee are not due to caffeine alone, but rather to other bioactive compounds in coffee. Therefore, coffee, in achievable amounts, may reduce both motor and cognitive deficits in aging.

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Section: Discussionsupporting

confidence: 86%

Section: Psychomotor Testsmentioning

confidence: 99%

Section: Cognitive Testingmentioning

confidence: 99%

See 1 more Smart Citation

Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging

Shukitt‐Hale

Miller

Chu

et al. 2013

AGE

Self Cite

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“…A battery of age-and diet-sensitive tests of psychomotor behavior (Joseph et al 1983Shukitt-Hale et al 1998;Joseph et al 1999;Youdim et al 2000;ShukittHale et al 2005) was administered in a randomized order to the animals at the end of the sixth week of dietary supplementation. Each test was performed once, separated by a break between tasks.…”

Section: Psychomotor Testingmentioning

confidence: 99%

Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats

Thangthaeng

Poulose

Gomes

et al. 2016

AGE

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High consumption of fruits and vegetables has been associated with reduced risk of debilitating diseases and improved cognition in aged populations. These beneficial effects have been attributed to the phytochemicals found in fruits and vegetables, which have previously been shown to be anti-inflammatory and modulate autophagy. Tart cherries contain a variety of potentially beneficial phytochemicals; however, little research has been done to investigate the effects of tart cherry on the aging brain. Therefore, the purpose of this study was to determine if tart cherry supplementation can improve cognitive and motor function of aged rats via modulation of inflammation and autophagy in the brain. Thirty 19-month-old male Fischer 344 rats were weight-matched and assigned to receive either a control diet or a diet supplemented with 2 % Montmorency tart cherry. After 6 weeks on the diet, rats were given a battery of behavioral tests to assess for strength, stamina, balance, and coordination, as well as learning and working memory. Although no significant effects were observed on tests of motor performance, tart cherry improved working memory of aged rats. Following behavioral testing, the hippocampus was collected for western/densitometric analysis of inflammatory (GFAP, NOX-2, and COX-2) and autophagy (phosphorylated mTOR, Beclin 1, and p62/SQSTM) markers. Tart cherry supplementation significantly reduced inflammatory markers and improved autophagy function. Daily consumption of tart cherry reduced age-associated inflammation and promoted protein/cellular homeostasis in the hippocampus, along with improvements in working memory. Therefore, addition of tart cherry to the diet may promote healthy aging and/or delay the onset of neurodegenerative diseases.

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“…The authors of this study relate the observed effects mainly to the rather unspecific antioxidant activity of catechin and other compounds contained in the preparation and fail to give further insights in the mechanisms related to the increase in mitochondrial SOD activity. Other investigators reported an attenuation of age-related decline in cognitive function and loss of behavioral deficits following long-term dietary supplementation with anthocyanidin-rich foods or plant extracts [90,91,216]. The investigators used several neuronal and behavioral parameters including dopamine-release, GTP-activity, calcium buffering in striatal synaptosomes, rod walking tasks and the water maze performance to elucidate possible mechanisms involved [90,91].…”

Section: Flavonoids: Neuroprotective Agents In Vivo and In Vitro?mentioning

confidence: 99%

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Schroeter

Boyd

Spencer

et al. 2002

Neurobiology of Aging

310

178

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Oxidative and nitrosative stress is increasingly associated with the pathology of neurodegeneration and aging. The molecular mechanisms underlying oxidative/nitrosative stress-induced neuronal damage are emerging and appear to involve a mode of death in which mitogen-activated protein kinase (MAPK) signaling pathways are strongly implicated. Thus, attention is turning towards the modulation of intracellular signaling as a therapeutic approach against neurodegeneration. Both endogenous and dietary agents have been suggested as potent modulators of intracellular signal transduction, e.g. nitric oxide and flavonoids, respectively. This review addresses recent findings on the biological effects of flavonoids and nitric oxide in neurodegeneration and aims to elucidate the rationale for their prospective use as modulators of cellular signal transduction. © 2002 Elsevier Science Inc. All rights reserved.Keywords: Apoptosis; Oxidative stress; Neuron; Flavonoids; MAP kinase; JNK; ERK; Epicatechin; Nitric oxide; Mitochondria; Redox status; Polyphenols Abbreviations: AKT, serine/threonine kinase (also known as protein kinase B); AP-1, activator protein-1; Apaf-1, apoptosis protease activating factor-1; ASK1, apoptosis signal-regulating kinase-1; Bad, Bcl-2/BclX Lassociated death promoting protein; Bax, pro-apoptotic protein of the Bcl-2 family; Bcl-2, B-cell lymphoma 2: protein with anti-apoptotic properties; BclX L , long form of Bclx: anti-apoptotic protein of the Bcl-2 family; Caspase, cysteinyl aspartic acid-protease; c-Jun, mammalian equivalent of Jun: part of the AP-1 transcription complex; CREB, cAMP response element binding protein; DIABLO/smac, mitochondria-related pro-apoptotic protein: inhibits XIAP; ERK1/2, extracellular signal-related kinase; Fas, CD95: member of the TNF receptor family; GSHST, glutathione Stransferase; JNK, c-Jun amino-terminal kinase; MAPK, mitogen-activated protein kinase; MAPKK, MAPK kinase; MAPKKK, MAPKK kinase; MEK1/2, ERK1/2-specific MAPKK; MKK4/7, JNK-specific MAPKK; MSK1, mitogen-and stress-activated kinase-1; NF-B, nuclear factor of immunoglobulin k locus in B-cells; ONOO − , peroxynitrite anion; p53, pro-apoptotic tumor suppressor gene product; PI3-kinase, phosphoinositol 3-kinase; Ras, small G-protein; RNS, reactive nitrogen species; ROS, reactive oxygen species; RSK, pp90 ribosomal S6 kinase; SAPK, stressactivated protein kinase; XIAP, X-linked inhibitor of apoptosis: inhibits the activation of caspase-9

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Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation

Cited by 857 publications

References 72 publications

Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging

Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging

Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

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