2009
DOI: 10.1242/dmm.001628
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Reverse translational strategies for developing animal models of bipolar disorder

Abstract: . (1995). Effects of chronic mild stress on serum complement activity, saccharin preference, and corticosterone levels in Flinders lines of rats. Physiol. Behav. 57, 165-169. Bachmann, R. F., Wang, Y., Yuan, P., Zhou, R., Li, X., Alesci, S., Du, J. and Manji, H. K. (2009).

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Cited by 63 publications
(47 citation statements)
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“…26,27 In rodents in which Grik2 is knocked out, a large number of behavioural traits have been interpreted as equivalents of clinical mania. 28 Major depressive disorder has been found to correlate with decreased GluK2 expression in the entorhinal cortex, 29 but mice in which Grik2 is knocked out display less despair during the forced swimming test and more social interaction, 30,31 suggesting that the knockout may make them more resistant to depression.…”
Section: Introductionmentioning
confidence: 99%
“…26,27 In rodents in which Grik2 is knocked out, a large number of behavioural traits have been interpreted as equivalents of clinical mania. 28 Major depressive disorder has been found to correlate with decreased GluK2 expression in the entorhinal cortex, 29 but mice in which Grik2 is knocked out display less despair during the forced swimming test and more social interaction, 30,31 suggesting that the knockout may make them more resistant to depression.…”
Section: Introductionmentioning
confidence: 99%
“…Most efforts have been devoted to the “bench to the bedside” (from animals to humans, or from basic to clinical research) approaches focusing on the design of animal models (particularly using rodents) that would be relevant to study the human disorders and to predict the therapeutic outcomes. Unfortunately, less research follows the opposite direction, using the reverse-translational approach and thus going from the bedside to the bench (from humans to animals) [144, 145]. However, when trying to assess the function of mechanisms discovered in animal models in the pathophysiology of human disorders and developing new treatments for these conditions, such reverse-translational approaches are crucial.…”
Section: Ppd and Anxiety As A Risk Factor For Depression And Anxiementioning
confidence: 99%
“…The current available animal models of BD permit the controlled study of a particular aspect of the illness, i.e. manic episodes, and its treatment (Machado-Vieira et al 2004;O'Donnell and Gould 2007;Malkesman et al 2009). …”
Section: Introductionmentioning
confidence: 99%