Reversed-phase liquid chromatograhy/electrospray ionization tandem mass spectrometry for analysis of perchlorate in water

Li, Yongtao; George, Ed J.

doi:10.1016/j.chroma.2006.08.029

Cited by 21 publications

(17 citation statements)

References 18 publications

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“…The presence of these common anions at the studied concentrations had no significant negative impact on perchlorate recoveries, which were in a range of 94%-108%. Additionally, peak shifting to earlier retention times was not observed for perchlorate [42]. These chromatographic conditions resulted in a rapid and successful isocratic separation of perchlorate from coexisting anions.…”

Section: Resultsmentioning

confidence: 83%

“…In this study, we investigated the occurrence of perchlorate in Italian bottled water using high performance liquid chromatography-electrospray tandem mass spectrometry (HPLC-ESI-MS/MS) [41,42]. This technique was further developed with a new reversed-phase LC method using a different column packing and new mobile phase composition to simplify the chromatographic separation and mass spectrometric detection.…”

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confidence: 99%

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Determination of Perchlorate in Bottled Water from Italy

Iannece

Motta

Tedesco

et al. 2013

Water

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Abstract:Perchlorate is regarded as an emerging persistent inorganic contaminant. It is widely known that perchlorate is an endocrine disruptor as it competitively inhibits iodide transport in the thyroid gland. As drinking water is the major source of human exposure to perchlorate, its occurrence in commercially available bottled waters purchased in different regions of Italy was investigated. Perchlorate was measured using the rapid, sensitive, and selective LC-ESI-MS/MS (liquid chromatography-electrospray tandem mass spectrometry) method by multiple reaction monitoring (MRM) of the transition 98.8→82.8, which corresponds to the loss of one oxygen atom in the perchlorate ion (ClO 4 Cl) was used as a confirmation tool. The limit of quantification (LOQ) for this method was 5 ng/L, and the recovery ranged from 94% to 108%. Perchlorate was detected in 44 of the 62 drinking waters tested, with concentrations ranging from <5 to 75 ng/L. These values are similar in magnitude to those reported in drinking water from the USA and do not pose an immediate health concern.

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Section: Resultsmentioning

confidence: 83%

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confidence: 99%

Determination of Perchlorate in Bottled Water from Italy

Iannece

Motta

Tedesco

et al. 2013

Water

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“…The mobile phase was a mixture of H 2 O/MeOH (70:30 v/v) with 0.1% formic acid, delivered using a Surveyor MS pump (Thermo Fisher Scientific, Waltham, MA, USA), equipped with a degasser unit, operated at a flow rate of 100 μL min –1 . Separation of these anions using a C 18 column has previously been achieved . In these studies, it was reported that the presence of organic solvent in the mobile phase caused further retention of the anions.…”

Section: Methodsmentioning

confidence: 99%

“…To date, several methods have been developed for the detection of these anions, including Ion Chromatography with Conductivity Detection (IC‐CD) and HPLC with electrospray ionization (ESI)‐MS detection . It is, therefore, also our objective to compare the analytical figures of merit of these methods with those established in the present study involving a newly developed SSI source for MS.…”

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confidence: 99%

Determination of chlorate, perchlorate and bromate anions in water samples by microbore reversed‐phase liquid chromatography coupled to sonic‐spray ionization mass spectrometry

Mavroudakis

Mavrakis

Kouvarakis

et al. 2017

Rapid Comm Mass Spectrometry

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This is the first time that the use of HPLC/SSI-MS/MS has been reported for the detection and quantitation of chlorate, perchlorate and bromate in water samples. In addition, the exceptionally low LODs achieved using SSI render the technique competitive with the established and dominating electrospray ionization technique. Here, we have demonstrated that a commercially available high-efficiency glass pneumatic nebulizer can also be used, without any further modification, as an efficient gas-phase ion source. Copyright © 2017 John Wiley & Sons, Ltd.

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“…A few anions in human amniotic fluids were studied by using IC/ESI/MS/MS that provided an LOD of 50 g/L for nitrate [28]. Recently, reversed-phase LC/ESI/MS/MS has been successfully used for the analysis of inorganic oxyhalides, such as bromate and perchlorate, at sub-g/L concentrations in aqueous samples without the use of ion-pairing agents [29][30][31].…”

Section: Introductionmentioning

confidence: 99%