Reversed‐Phase Thin‐Layer Chromatography of Three New Oral Antidiabetics and Densitometric Determination of Pioglitazone

Gumieniczek, Anna; Hopkała, Hanna; Berecka, Anna

doi:10.1081/jlc-120039418

Cited by 28 publications

(12 citation statements)

References 14 publications

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“…The calibration curve was found to be linear between 100 and 3000 ng/mL. Gumieniczek et al [73] reported a thin‐layer chromatographic behavior of three antidiabetic drugs PIO, rosiglitazone and repaglinide and then they developed stability‐indicating HPTLC method for determination of PIO in tablets. The mobile phase consisted of 1,4‐dioxane and phosphate buffer of pH 4.4 (5:5).…”

Section: Methodsmentioning

confidence: 99%

Pioglitazone: A review of analytical methods

Satheeshkumar

Saladi

Srinivas

2014

Journal of Pharmaceutical Analysis

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Pioglitazone is an oral anti-hyperglycemic agent. It is used for the treatment of diabetes mellitus type 2. It selectively stimulates nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma). It was the tenth-best-selling drug in the U.S. in 2008. This article examines published analytical methods reported so far in the literature for the determination of pioglitazone in biological samples and pharmaceutical formulations. They include various techniques like electrochemical methods, spectrophotometry, capillary electrophoresis, high-performance liquid chromatography, liquid chromatography–electrospray ionization-tandem mass spectrometry and high-performance thin layer chromatography.

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Section: Methodsmentioning

confidence: 99%

Pioglitazone: A review of analytical methods

Satheeshkumar

Saladi

Srinivas

2014

Journal of Pharmaceutical Analysis

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“…Several methods such as potentiometry , voltametry , spectrophotometry , GC , HPLC , TLC , LC–MS/MS , atomic absorption spectrometry , and CE have been reported for the determination of pioglitazone. Most commonly, spectrophotometry and HPLC methods are used for the analysis of this drug.…”

Section: Introductionmentioning

confidence: 99%

Selective extraction and analysis of pioglitazone in cow plasma using a molecularly imprinted polymer combined with ESI ion mobility spectrometry

et al. 2014

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A method based on ESI ion mobility spectrometry as a detection technique after treatment with a molecularly imprinted polymer is described for the analysis of pioglitazone. In addition to the molecularly imprinted polymer separation methodology, the positive ion mobility spectrum and the reduced mobility values for pioglitazone are reported for the first time. The method was exhaustively validated in terms of sensitivity, imprinting factor, enrichment factor, and sorption capacity. A linear dynamic range of 0.10-20.00 μg/mL and an RSD below 6% were obtained for the analysis of this compound. The average recovery for the analysis of spiked samples was calculated to be about 91%. The method was also used to determine pioglitazone in cow plasma, and the results were compared with those obtained using HPLC. The satisfactory results evidence a convenient method for the analysis of the target compound in real samples without using any additional derivatization methods.

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“…Most of the reported methods are chromatographic methods and no official methods have been reported for the determination of pioglitazone HCl. The reported methods include: high performance liquid chromatography with ultraviolet detection (HPLC-UV), [4][5][6][7][8] high performance liquid chromatography with mass spectroscopy (HPLC/MS), 9 high performance liquid chromatography with tandem mass spectroscopy (HPLC/MS/MS), 10,11 high performance thin layer chromatography (HPTLC), 12 thin layer chromatography (TLC), 13,14 miceller electrokinetic chromatography (MEKC) 15 and capillary electrophoresis method (CE). 16,17 Other reported methods include a potentiometric method 18 and UV spectrophotometric methods.…”

Section: Introductionmentioning

confidence: 99%

Flow-Injection Chemiluminometric Determination of Pioglitazone HCl by Its Sensitizing Effect on the Cerium-Sulfite Reaction

2009

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A flow injection chemiluminescent (FI-CL) method was developed for the determination of pioglitazone HCl. It is based on the sensitizing effect of the drug on the oxidation reaction of sulfite with cerium(IV). The different experimental parameters affecting the chemiluminescence intensity, such as concentration of reagents and some physical parameters of the manifold, were carefully studied and incorporated into the procedure. The method permits the determination of 0.05 - 3.0 microg ml(-1) of pioglitazone HCl with correlation coefficient r = 0.9999. The lower limit of detection (LOD) is 0.01 microg ml(-1) (S/N = 2) and the lower limit of quantitation (LOQ) is 0.05 microg ml(-1). The proposed method was compared with other reported methods and was found to be equally accurate and precise. It was successfully applied to the determination of the drug in pharmaceutical preparations and in biological fluids.

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Reversed‐Phase Thin‐Layer Chromatography of Three New Oral Antidiabetics and Densitometric Determination of Pioglitazone

Cited by 28 publications

References 14 publications

Pioglitazone: A review of analytical methods

Pioglitazone: A review of analytical methods

Selective extraction and analysis of pioglitazone in cow plasma using a molecularly imprinted polymer combined with ESI ion mobility spectrometry

Flow-Injection Chemiluminometric Determination of Pioglitazone HCl by Its Sensitizing Effect on the Cerium-Sulfite Reaction

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