1979
DOI: 10.1083/jcb.82.3.597
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Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins.

Abstract: Mouse peritoneal macrophages accumulate large amounts of cholesteryl ester when incubated with human low-density lipoprotein that has been modified by chemical acetylation (acetyl-LDL) . This accumulation is related to a high-affinity cell surface binding site that mediates the uptake of acetyl-LDL by adsorptive endocytosis and its delivery to lysosomes. The current studies demonstrate that the cholesteryl ester accumulation can be considered in terms of a two-compartment model: (a) the incoming cholesteryl e… Show more

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Cited by 494 publications
(271 citation statements)
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“…14 Heparin, a sulfated polysaccharide, prevents the binding of LDL to its cell-surface receptor on fibroblasts. 30 Heparin inhibited the uptake and degradation of 125 I-PLC-LDL and 125 I-LDL by human macrophages to a similar degree, while little affecting 125 I-acetylated LDL degradation. Finally, changes in LDL receptor number alter the rate of 125 I-PLC-LDL degradation by human macrophages.…”
Section: Discussionmentioning
confidence: 87%
See 1 more Smart Citation
“…14 Heparin, a sulfated polysaccharide, prevents the binding of LDL to its cell-surface receptor on fibroblasts. 30 Heparin inhibited the uptake and degradation of 125 I-PLC-LDL and 125 I-LDL by human macrophages to a similar degree, while little affecting 125 I-acetylated LDL degradation. Finally, changes in LDL receptor number alter the rate of 125 I-PLC-LDL degradation by human macrophages.…”
Section: Discussionmentioning
confidence: 87%
“…Mouse macrophages exposed to acetylated LDL for longer times have similar electron-dense inclusions. 30 To test the role of cell-surface receptors in mediating the uptake of PLC-LDL, we examined the influence of polyanionic compounds on the degradation of 125 I-PLC-LDL by human monocyte-derived macrophages. Heparin, a sulfated polysaccharide, competes with LDL for binding to its receptor.…”
mentioning
confidence: 99%
“…2 Oxidation of LDL is considered to be an important step in the development of fatty streaks. 3 Macrophages do not engulf native LDL quickly enough to form foam cells, 4 but oxidized LDL is recognized by macrophage scavenger receptors, 4,5 leading to fast, unregulated LDL uptake and foam cell formation. 1,3,6 Oxidation of LDL occurs after it has become trapped in the subendothelial matrix because at that site it loses the protection of plasma antioxidants.…”
mentioning
confidence: 99%
“…Therefore, inhibition of lipid droplet accumulation in macrophages would be expected to retard the progression of atherosclerosis. [1][2][3][4] In the course of our screening program for microbial inhibitors of lipid droplet formation in mouse macrophages, [5][6][7][8][9][10] three new compounds designated pentacecilides A to C (Figure 1), structurally related to known thailandolides A and B, 11 were isolated from the culture broth of a soil-isolated fungus, FKI-3765-1. Thailandolides were originally isolated as fungal metabolites from Talaromyces thailandiasis, 11 and were not isolated from the culture broth of strain FKI-3765-1.…”
Section: Introductionmentioning
confidence: 99%