Reversible Acute Renal Failure Induced by Indomethacin

Fawaz-Estrup, Faiza; Ho, George

doi:10.1001/archinte.1981.00340130108025

Cited by 29 publications

(3 citation statements)

References 8 publications

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“…Another potential mechanism of hyperkalemia is decreased distal tubular delivery of sodium, secondary to decreased renal blood flow, resulting from decreased synthesis of vasodilatory prostaglandins 2,5 . In a few reported cases there has been evidence of a drug‐induced allergic interstitial nephritis (eosinophilia, urinary eosinophils, fever) as an explanation for the findings 15,16 …”

Section: Discussionmentioning

confidence: 99%

Indomethacin‐Associated Hyperkalemia in the Elderly

Meier¹,

Myers²,

Swenson

et al. 1983

J American Geriatrics Society

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Section: Discussionmentioning

confidence: 99%

Indomethacin‐Associated Hyperkalemia in the Elderly

Meier¹,

Myers²,

Swenson

et al. 1983

J American Geriatrics Society

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“…We performed a secondary analysis of data from the Osteoarthritis Initiative (OAI). The OAI is a longitudinal, NIH/NIA-funded cohort study of men and women, aged 45-79 years at enrolment, who either had knee OA or were at high risk for developing knee OA at their baseline study visit (Fawaz-Estrup, 2004). The OAI enroled a total of 4796 adults between 2004 and 2006; specific inclusion and exclusion criteria for the OAI have been published elsewhere (Felson & Nevitt, 2004;Lester, 2008).…”

Section: The Osteoarthritis Initiativementioning

confidence: 99%

Sitting may increase risk for radiographic incidence and progression of knee osteoarthritis over 2 years: Data from a large cohort study

Voinier

Neogi

Master

et al. 2023

Musculoskeletal Care

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ObjectivesTo examine the association of leisure‐time sitting with radiographic incidence and progression of knee osteoarthritis (OA) over 2 years, and to determine whether worktime sitting modifies this association.MethodsWe included adults with or at high risk for knee OA who enroled in the Osteoarthritis Initiative (OAI). Participants reported leisure‐time sitting (≤4 vs. >4 h/day) and worktime sitting (frequent vs. infrequent) at enrolment, and had bilateral knee radiographs at enrolment and 2 years later. Our outcome, radiographic knee OA incidence/progression (yes/no), was defined as any increase in Kellgren‐Lawrence grade over 2 years. We examined the association of leisure‐time sitting (≤4 vs. >4 h/day) with risk of radiographic knee OA incidence/progression using binary linear regression, adjusting for potential confounders. We stratified by worktime sitting (frequent vs. infrequent) and repeated our analysis.ResultsWe included 4254 adults (mean age 61 years; 58% women; mean body mass index 29 kg/m2) who contributed a total of 8127 knees. Adults with >4 h/day of leisure‐time sitting had 25% higher risk (adjusted risk ratio [RR] 1.25, 95% confidence interval [95% CI] 1.08–1.50) for radiographic knee OA incidence/progression compared with adults with ≤4 h/day of leisure‐time sitting (referent group). Importantly, this association was intensified (RR 1.60, 95% CI 1.19–2.33) among adults with frequent worktime sitting, but was attenuated (RR 1.11, 95% CI 0.89–1.39) among adults with infrequent worktime sitting.ConclusionsHigher leisure‐time sitting (>4 h/day) may be associated with greater risk for radiographic knee OA incidence/progression over 2 years. Furthermore, this association was intensified among adults who also reported frequent worktime sitting.

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“…The clinical entities associated with this combination of events include type 2 diabetes, [8] obstructive uropathy, [9,10] multiple myeloma, [10] prerenal azotemia, [10][11][12][13][14] hypertensive nephrosclerosis, [10] interstitial nephritis, [15] renal vascular disease, [16][17][18][19] hypokalemic nephropathy, [20] and hypercalcemia. [21] In addition, renal failure with a normal urinalysis has also been associated with the use of indomethacin [22][23][24] and lithium. [18,[25][26][27] An extensive MEDLINE search spanning the years 1966 to the present did not produce any literature that directly studied the phenomenon of renal failure with a normal urinalysis.…”

Section: Introductionmentioning

confidence: 99%

Elevated Serum Creatinine and a Normal Urinalysis: A Short Differential Diagnosis in the Etiology of Renal Failure

2006

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An elevated serum creatinine and normal urinalysis present a short differential for the etiologies of renal failure and include such entities as hypertensive nephrosclerosis, prerenal azotemia, obstructive nephropathy, interstitial nephritis, renal vascular disease, and various electrolyte abnormalities. An awareness of these specific disease states may lead to an earlier diagnosis and more effective treatment of renal failure.

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Reversible Acute Renal Failure Induced by Indomethacin

Cited by 29 publications

References 8 publications

Indomethacin‐Associated Hyperkalemia in the Elderly

Indomethacin‐Associated Hyperkalemia in the Elderly

Sitting may increase risk for radiographic incidence and progression of knee osteoarthritis over 2 years: Data from a large cohort study

Elevated Serum Creatinine and a Normal Urinalysis: A Short Differential Diagnosis in the Etiology of Renal Failure

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