Reversible angiopathy and encephalopathy after blood transfusion

Boughammoura, A.; Touzé, Emmanuel; Oppenheim, Catherine; Trystram, Denis; Mas, Jean‐Louis

doi:10.1007/s00415-003-0940-4

Cited by 50 publications

(34 citation statements)

References 7 publications

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“…Another explanation is "vasospasm" of arteries in the brain. In fact, vasospasm was observed in RPLS patients on brain MR angiography [2] or conventional angiography [2][3][4]. In our patient, systemic hypertension was not observed in spite of repeated measurements of her blood pressure.…”

contrasting

confidence: 62%

“…An interval of several days between blood transfusion and the onset of symptoms are a feature of RPLS after blood transfusion [2][3][4]. Although the neurological symptoms and MRI findings of the reported patients disappeared almost completely, the neurological deficits and MRI lesions of our patient persist even now, 12 months after onset.…”

contrasting

confidence: 53%

“…However, the risk of blood transfusion for chronic anemia is not generally recognized. There have been three case reports of reversible posterior leukoencephalopathy syndrome (RPLS) [1] after blood transfusion for chronic anemia [2][3][4]. We describe a patient who suffered irreversible brain damage after blood transfusion.…”

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confidence: 93%

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Blood transfusion–induced irreversible brain damage

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Blood transfusion–induced irreversible brain damage

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“…6 A diverse group of possible exogenous triggers for secondary RCVS have been proposed, though the potential delay between exposure and development of the syndrome (in some cases weeks to months) and the ubiquity of some triggers (coughing, laughing, and so forth) raise the possibility that some of these associations may be coincidental (Table 1). 2,3,6,11,23,[28][29][30][31][32][33][34][35][36][37][38] However, the association of RCVS with the most commonly reported triggers is more compelling, including the use of vasoactive drugs and the postpartum state, which together account for more than half of cases in most published series (approximately 50% and 9%-10% of cases respectively). 7,17,39 Sympathomimetic drugs commonly taken over the counter for upper respiratory tract infections, including phenylpropanolamine and pseudoephedrine, as well as antimigrainous medications, have historically been associated with subarachnoid hemorrhage and ischemic stroke in rare cases, which in retrospect likely reflects the sequelae of drug-induced RCVS.…”

Section: Epidemiology and Potential Triggersmentioning

confidence: 99%

Reversible Cerebral Vasoconstriction Syndrome, Part 1: Epidemiology, Pathogenesis, and Clinical Course

Miller

Shivashankar

Mossa‐Basha

et al. 2015

AJNR Am J Neuroradiol

208

194

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SUMMARY:Reversible cerebral vasoconstriction syndrome is a clinical and radiologic syndrome that represents a common presentation of a diverse group of disorders. The syndrome is characterized by thunderclap headache and reversible vasoconstriction of cerebral arteries, which can either be spontaneous or related to an exogenous trigger. The pathophysiology of reversible cerebral vasoconstriction syndrome is unknown, though alterations in cerebral vascular tone are thought to be a key underlying mechanism. The syndrome typically follows a benign course; however, reversible cerebral vasoconstriction syndrome may result in permanent disability or death in a small minority of patients secondary to complications such as ischemic stroke or intracranial hemorrhage.ABBREVIATIONS: RCVS ϭ reversible cerebral vasoconstriction syndrome; PRES ϭ posterior reversible encephalopathy syndrome

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“…The case reports of PRES associated with blood transfusion are represented in Table 3 [20][21][22][23][24][25][26]. Abrupt or acute cerebral hyperperfusion exceeding the capacity of auto-regulation of cerebral capillary perfusion pressure might result in vasogenic edema found in PRES.…”

Section: Discussionmentioning

confidence: 99%

Posterior Reversible Encephalopathy Syndrome: Case Report

Sodalagunta¹,

Sudulagunta

Kumbhat

et al. 2016

J Neurol Res

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Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological syndrome characterized by headache, seizures, altered mental status, and visual loss, as well as white matter vasogenic edema affecting the posterior occipital and parietal lobes of the brain predominantly. This clinical syndrome is increasingly recognized due to improvement and availability of brain imaging, specifically magnetic resonance imaging (MRI). A 35-year-old female with history of unsafe abortion and massive blood transfusion 10 days ago was brought to the emergency room with three episodes of generalized tonic clonic seizures, urinary incontinence and altered sensorium since 3 hours. Brain MRI showed bilateral occipital, parietal, frontal cortex and subcortical white matter T2/fluid-attenuated inversion recovery (FLAIR) hyperintensities, suggestive of PRES. Patient improved after management with intravenous fluids, antibiotics, antiepileptics and monitoring of blood pressure. If recognized and treated early, the clinical syndrome commonly resolves within a week. PRES can be a major problem in rapid and massive blood transfusion. High index of suspicion and prompt treatment can reduce morbidity and mortality, and pave the path for early recovery.

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Reversible angiopathy and encephalopathy after blood transfusion

Cited by 50 publications

References 7 publications

Blood transfusion–induced irreversible brain damage

Blood transfusion–induced irreversible brain damage

Reversible Cerebral Vasoconstriction Syndrome, Part 1: Epidemiology, Pathogenesis, and Clinical Course

Posterior Reversible Encephalopathy Syndrome: Case Report

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