Reversible antibiotic loading and pH-responsive release from polymer brushes on contact lenses for therapy and prevention of corneal infections

Guo, Yishun; Qian, Siyuan; Wang, Lu; Zeng, Jiahong; Miao, Renjie; Meng, Yongchun; Jin, Yingying; Chen, Hao; Wang, Bailiang

doi:10.1039/d0tb01508c

Cited by 22 publications

(10 citation statements)

References 29 publications

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“…As for the infectious keratitis model, the bacterial‐induced keratitis model was established on rat eyes according to the method in the previous report. [ 43 ] Rats were anesthetized using chloral hydrate via intraperitoneal injection (3.5 mL kg −1 ). Under sterile conditions, a razor was used to scrape about 2/3 of the corneal epithelium in the center of the cornea, and then MRSA suspension was dripped onto the cornea (10 µL, 1 × 10 8 CFU/mL).…”

Section: Methodsmentioning

confidence: 99%

Continuous Self‐Oxygenated Double‐Layered Hydrogel under Natural Light for Real‐Time Infection Monitoring, Enhanced Photodynamic Therapy, and Hypoxia Relief in Refractory Diabetic Wounds Healing

Zhu

Wang

Peng

et al. 2022

Adv Funct Materials

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The human health is still threatened by refractory keratitis and diabetic foot ulcers caused by bacterial infections, hypoxia, and chronic inflammation, so that patients are exposed to the risk of amputation, vision loss, and even death. Herein, an oxygen-producing double-layered hydrogel is developed that can visualize bacterial infections and supply oxygen to enhance antimicrobial photodynamic therapy (PDT) and inflammation alleviation for diabetic wounds healing. The inner layer hydrogel (containing oxidized sodium alginate/carboxymethyl chitosan [CMCS] via Schiff-base) is incorporated with a photodynamic metal-organic framework (PCN-224) and a pH indicator (bromothymol blue). The outer layer hydrogel (containing agarose and CMCS) loads photosynthetic cyanobacteria that continuously generate oxygen to relieve hypoxia of tissue and enhance antimicrobial PDT efficiency. Meanwhile, some unique advantages are reflected by continuous oxygen supply under natural light, such as cell migration acceleration, inflammation relief, promotion of skin capillary formation, and wound tissue recovery. Therefore, the self-oxygenated double-layered hydrogel offers tremendous benefits in the synergistic treatment of refractory anaerobe wounds from timely infection monitoring to tissue repair.

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Section: Methodsmentioning

confidence: 99%

Continuous Self‐Oxygenated Double‐Layered Hydrogel under Natural Light for Real‐Time Infection Monitoring, Enhanced Photodynamic Therapy, and Hypoxia Relief in Refractory Diabetic Wounds Healing

Zhu

Wang

Peng

et al. 2022

Adv Funct Materials

Self Cite

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“…Along similar lines, a pH‐responsive coating was obtained via surface‐initiated reversible addition–fragmentation chain transfer polymerization (SI‐RAFT) of phenylboronic acid monomers (4‐allylaminocarbonylphenylboronic acid, ACPA) into uniform brushes. [ 156 ] The dynamic covalent bonds between hydroxyls of vancomycin and phenylboronic acid (PCVB) were used to facilitate drug loading. These interactions possessed sensitivity toward acidic pH that can be generated because of bacterial infection.…”

Section: Therapeutic Release From Ocular Implantsmentioning

confidence: 99%

Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants

et al. 2023

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The deployment of structures that enable localized release of bioactive molecules can result in more efficacious treatment of disease and better integration of implantable bionic devices. The strategic design of a biopolymeric coating can be used to engineer the optimal release profile depending on the task at hand. As illustrative examples, here advances in delivery of drugs from bone, brain, ocular, and cardiovascular implants are reviewed. These areas are focused to highlight that both hard and soft tissue implants can benefit from controlled localized delivery. The composition of biopolymers used to achieve appropriate delivery to the selected tissue types, and their corresponding outcomes are brought to the fore. To conclude, key factors in designing drug-loaded biopolymeric coatings for biomedical implants are highlighted.

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“…strategies broaden the path for treating and preventing bacterial keratitis. [209] In addition to utilizing pH-sensitive bonds, inherently pHsensitive nanomaterials can also be used. Based on the changes in pH in the infected microenvironment, Kong et al synthesized core-shell structured Cu 2 O@Ag@CS nanocomposites, with CS shells controlling the release of Cu 2+ and Ag + ions based on the environmental pH change caused by bacteria to achieve targeted bactericidal activity, significantly improving the efficiency of Cu 2 O utilization (Figure 9b).…”

Section: Targeted Inflammatory Acidic Phmentioning

confidence: 99%

Nanomedicine for the Detection and Treatment of Ocular Bacterial Infections

Huang

Chen

et al. 2023

Advanced Materials

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Ocular bacterial infection is a prevalent cause of blindness worldwide, with substantial consequences for normal human life. Traditional treatments for ocular bacterial infections are ineffective, necessitating the development of novel techniques to enable accurate diagnosis, precise drug delivery, and effective treatment alternatives. With the rapid advancement of nanoscience and biomedicine, increasing emphasis has been placed on multifunctional nanosystems to overcome the challenges posed by ocular bacterial infections. Given the advantages of nanotechnology in the biomedical industry, it can be utilized to diagnose ocular bacterial infections, administer medications, and treat them. In this review, the recent advancements in nanosystems for the detection and treatment of ocular bacterial infections are discussed; this includes the latest application scenarios of nanomaterials for ocular bacterial infections, in addition to the impact of their essential characteristics on bioavailability, tissue permeability, and inflammatory microenvironment. Through an in‐depth investigation into the effect of sophisticated ocular barriers, antibacterial drug formulations, and ocular immune metabolism on drug delivery systems, this review highlights the challenges faced by ophthalmic medicine and encourages basic research and future clinical transformation based on ophthalmic antibacterial nanomedicine.This article is protected by copyright. All rights reserved

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Reversible antibiotic loading and pH-responsive release from polymer brushes on contact lenses for therapy and prevention of corneal infections

Abstract: Corneal infection is an important cause of corneal damage and vision loss. In this work, polyhydroxy antibiotics were grafted onto polymer brushes modified contact lens through dynamic chemical bonds between...

Cited by 22 publications

References 29 publications

Continuous Self‐Oxygenated Double‐Layered Hydrogel under Natural Light for Real‐Time Infection Monitoring, Enhanced Photodynamic Therapy, and Hypoxia Relief in Refractory Diabetic Wounds Healing

Continuous Self‐Oxygenated Double‐Layered Hydrogel under Natural Light for Real‐Time Infection Monitoring, Enhanced Photodynamic Therapy, and Hypoxia Relief in Refractory Diabetic Wounds Healing

Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants

Nanomedicine for the Detection and Treatment of Ocular Bacterial Infections

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