1984
DOI: 10.1016/s0015-0282(16)47899-4
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Reversible hypogonadism induced by a luteinizing hormone-releasing hormone (LH-RH) agonist (Buserelin) as a new therapeutic approach for endometriosis

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Cited by 219 publications
(54 citation statements)
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“…1). During such a supraphysiological stimulation, the gonadotrophin becomes refractory to a subsequent dose for several hours after the initial dosing [2], Repetitive administration produces a progressive in hibition of gonadotrophin, and the more frequent the administration, the greater the decrease in circulating LH and FSH levels [3,4].…”
Section: Gonadotrophin Down-regulationmentioning
confidence: 99%
See 1 more Smart Citation
“…1). During such a supraphysiological stimulation, the gonadotrophin becomes refractory to a subsequent dose for several hours after the initial dosing [2], Repetitive administration produces a progressive in hibition of gonadotrophin, and the more frequent the administration, the greater the decrease in circulating LH and FSH levels [3,4].…”
Section: Gonadotrophin Down-regulationmentioning
confidence: 99%
“…or s.c. buserelin, although the fall in E2 level with the i.n. insufflation was less than with with s.c. injection 11 (3]. For long-term treatment (2=6 months) or chronic gynaecolo gical conditions such as recurrent endometriosis with pel vic pain or dysfunction uterine bleeding, it is likely that a dosage regimen using a once daily i.n.…”
Section: Time Of Treatment During Cyclementioning
confidence: 99%
“…A year later, Lemay et al [3] published the results of treating 10 women for up to 6 months with buserelin. Initially, twice-daily subcutaneous injections of buserelin were given followed by 400 pg intranasally, three times daily for 25-31 weeks.…”
Section: Lhrh Analogues In the Treatment Of Endometriosismentioning
confidence: 99%
“…Several LHRH analogues can induce reversible pseudo-menopause for the treatment of sex steroid-dependent gynaecological conditions such as en dometriosis, leiomyoma uteri and polycystic ovarian dis ease [1][2][3][4][5][6][7][8][9][10]. Their main side effects are related to oes trogen deprivation.…”
Section: Introductionmentioning
confidence: 99%