“…Some predisposing factors may be involved, including scleroderma, systemic lupus erythematosus, granulomatosis with polyangiitis, amyloidosis, myeloma, dermatomyositis, COPD, Crohn's disease, nutritional imbalances, dysbacteriosis, gastrointestinal dysmotility, alpha-glucosidase inhibitor, glucocorticoid, kinin, immunosuppressant inhibitor, bone marrow transplantation, lung transplantation, graft versus host disease, and use of trichloroethylene 1,2,3,7,11,14,23,28,31,32 . Changes in immune function appear to be among the most significant predisposing factors, considering their relation with post-transplant organ status, corticotherapy, rheumatic disease treatment, and chemotherapy 2,33,34 .…”