Reversible, Spatial and Temporal Control over Protein Activity Using Light

Hoorens, Mark W. H.; Szymański, Wiktor

doi:10.1016/j.tibs.2018.05.004

Cited by 110 publications

(104 citation statements)

References 63 publications

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“…Often, one of those isomers is less stable and thermally converts back over time to the stable isomer. The two photo-isomers of the switch differ in structure and chemical properties, which enables photochemical control of the systems in which they are embedded 1–4 , including drugs and their protein targets 5,6 , drug delivery systems 7,8 , the function of hydrogels in regenerative medicine 9 , the conformation of peptides 10 and nucleotides 11 . Fascinating applications in bio-imaging 12,13 and vision restoration 14 are also emerging.…”

Section: Introductionmentioning

confidence: 99%

Iminothioindoxyl as a molecular photoswitch with 100 nm band separation in the visible range

et al. 2019

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Light is an exceptional external stimulus for establishing precise control over the properties and functions of chemical and biological systems, which is enabled through the use of molecular photoswitches. Ideal photoswitches are operated with visible light only, show large separation of absorption bands and are functional in various solvents including water, posing an unmet challenge. Here we show a class of fully-visible-light-operated molecular photoswitches, Iminothioindoxyls (ITIs) that meet these requirements. ITIs show a band separation of over 100 nm, isomerize on picosecond time scale and thermally relax on millisecond time scale. Using a combination of advanced spectroscopic and computational techniques, we provide the rationale for the switching behavior of ITIs and the influence of structural modifications and environment, including aqueous solution, on their photochemical properties. This research paves the way for the development of improved photo-controlled systems for a wide variety of applications that require fast responsive functions.

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Section: Introductionmentioning

confidence: 99%

Iminothioindoxyl as a molecular photoswitch with 100 nm band separation in the visible range

et al. 2019

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“…Materials with embedded switches that respond to light were among the first responsive materials to be reported 23,24. Photoswitches are a particularly attractive tool as the stimulus, light, can be applied with both temporal and spatial control and modified through light intensity, wavelength and irradiation time 25–27. As a result, there are a plethora of reports demonstrating the responsive behavior in the fields of drug delivery, 3D‐printing, sensing, microscopy and information technology 28–33.…”

Section: Aqueous Stimuli‐responsive Materialsmentioning

confidence: 99%

Design Principles for Aqueous Interactive Materials: Lessons from Small Molecules and Stimuli‐Responsive Systems

et al. 2020

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Interactive materials are at the forefront of current materials research with few examples in the literature. Researchers are inspired by nature to develop materials that can modulate and adapt their behavior in accordance with their surroundings. Stimuli‐responsive systems have been developed over the past decades which, although often described as “smart,” lack the ability to act autonomously. Nevertheless, these systems attract attention on account of the resultant materials' ability to change their properties in a predicable manner. These materials find application in a plethora of areas including drug delivery, artificial muscles, etc. Stimuli‐responsive materials are serving as the precursors for next‐generation interactive materials. Interest in these systems has resulted in a library of well‐developed chemical motifs; however, there is a fundamental gap between stimuli‐responsive and interactive materials. In this perspective, current state‐of‐the‐art stimuli‐responsive materials are outlined with a specific emphasis on aqueous macroscopic interactive materials. Compartmentalization, critical for achieving interactivity, relies on hydrophobic, hydrophilic, supramolecular, and ionic interactions, which are commonly present in aqueous systems and enable complex self‐assembly processes. Relevant examples of aqueous interactive materials that do exist are given, and design principles to realize the next generation of materials with embedded autonomous function are suggested.

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“…Over the years, many examples of strategies used to control biological processes have been reported . Of those, a significant number have been relying on the use of photocleavable groups to “cage” the activity of proteins or nucleic acids.…”

Section: Control Of Biological Activitymentioning

confidence: 99%

The Role of Photochemical Reactions in the Development of Advanced Soft Materials for Biomedical Applications

Fernandez‐Villamarin

Brooks

Mendes

2019

Advanced Optical Materials

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In the biomedical field, many innovative materials to improve diagnosis and treatment of diseases are currently being developed. The ability to respond to different stimuli is one of the more interesting properties of such materials. Light, as one of the nature's elementary stimuli, offers an attractive and flexible stimulus for controlling the properties and functions of biomedical‐related materials. As such, photoresponsive systems have been increasingly pursued and finding applications in various biomedical settings, ranging from tissue engineering for the fabrication of bespoke tissue scaffolds to drug delivery, aims at manipulating treatment distribution inside the human body. Efforts have also been devoted to the development of highly efficient methods to control biological activity and bring us closer to mimicking impressive biological actuators. In this progress report, an overview of recent developments in the field is provided and current challenges discussed. Key strategies tailored to address specific issues are examined, offering useful perspectives for future designs.

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Reversible, Spatial and Temporal Control over Protein Activity Using Light

Cited by 110 publications

References 63 publications

Iminothioindoxyl as a molecular photoswitch with 100 nm band separation in the visible range

Iminothioindoxyl as a molecular photoswitch with 100 nm band separation in the visible range

Design Principles for Aqueous Interactive Materials: Lessons from Small Molecules and Stimuli‐Responsive Systems

The Role of Photochemical Reactions in the Development of Advanced Soft Materials for Biomedical Applications

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