Reversible speed control of one-stimulus-double-response, temperature-sensitive asymmetric hydrogel micromotors

Teora, Serena P.; Knaap, Kirsten Helena van der; Keller, Shauni; Rijpkema, Sjoerd Johannes; Wilson, Daniela A.

doi:10.1039/d2cc02854a

Cited by 4 publications

(3 citation statements)

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“…The versatility of microfluidics for the generation of asymmetric microparticles has already been reported by our group [53,54]. Taking advantage of this knowledge, we used a microfluidic device with three (Figure 1) and two inlets (Figure S2, Supplementary Materials) to prepare asymmetric and spherical microgels, respectively (Figure S3, Supplementary Materials).…”

Section: Microfluidics For the Generation Of Pegda-alma Microparticlesmentioning

confidence: 90%

Anisotropic, Hydrogel Microparticles as pH-Responsive Drug Carriers for Oral Administration of 5-FU

Teora¹,

Panavaité²,

Sun³

et al. 2023

Pharmaceutics

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In the last 20 years, the development of stimuli-responsive drug delivery systems (DDS) has received great attention. Hydrogel microparticles represent one of the candidates with the most potential. However, if the role of the cross-linking method, polymer composition, and concentration on their performance as DDS has been well-studied, still, a lot needs to be explained regarding the effect caused by the morphology. To investigate this, herein, we report the fabrication of PEGDA–ALMA-based microgels with spherical and asymmetric shapes for 5-fluorouracil (5-FU) on-demand loading and in vitro pH-triggered release. Due to anisotropic properties, the asymmetric particles showed an increased drug adsorption and higher pH responsiveness, which in turn led to a higher desorption efficacy at the target pH environment, making them an ideal candidate for oral administration of 5-FU in colorectal cancer. The cytotoxicity of empty spherical microgels was higher than the cytotoxicity of empty asymmetric microgels, suggesting that the gel network’s mechanical proprieties of anisotropic particles were a better three-dimensional environment for the vital functions of cells. Upon treatment with drug-loaded microgels, the HeLa cells’ viability was lower after incubation with asymmetric particles, confirming a minor release of 5-FU from spherical particles.

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Section: Microfluidics For the Generation Of Pegda-alma Microparticlesmentioning

confidence: 90%

Anisotropic, Hydrogel Microparticles as pH-Responsive Drug Carriers for Oral Administration of 5-FU

Teora¹,

Panavaité²,

Sun³

et al. 2023

Pharmaceutics

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“…There are many different aspects of a motor's design that influence motion, as Gels 2023, 9, 164 2 of 10 well. These include roughness [6,7], shape [7][8][9][10][11], and the materials of which the motors are made [6,12,13]. One of the main requirements of designing a self-motile system is asymmetry, which affects the motor's behaviour greatly.…”

Section: Introductionmentioning

confidence: 99%

Spatial Control over Catalyst Positioning for Increased Micromotor Efficiency

Keller¹,

Teora²,

Keskin³

et al. 2023

Gels

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Motion is influenced by many different aspects of a micromotor’s design, such as shape, roughness and the type of materials used. When designing a motor, asymmetry is the main requirement to take into account, either in shape or in catalyst distribution. It influences both speed and directionality since it dictates the location of propulsion force. Here, we combine asymmetry in shape and asymmetry in catalyst distribution to study the motion of soft micromotors. A microfluidic method is utilized to generate aqueous double emulsions, which upon UV-exposure form asymmetric microgels. Taking advantage of the flexibility of this method, we fabricated micromotors with homogeneous catalyst distribution throughout the microbead and micromotors with different degrees of catalyst localization within the active site. Spatial control over catalyst positioning is advantageous since less enzyme is needed for the same propulsion speed as the homogeneous system and it provides further confinement and compartmentalization of the catalyst. This proof-of-concept of our new design will make the use of enzymes as driving forces for motors more accessible, as well as providing a new route for compartmentalizing enzymes at interfaces without the need for catalyst-specific functionalization.

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“…6 Another study explored the fabrication of thermo-responsive microgels using a microfluidic chip, involving materials like Poly(ethylene glycol) diacrylate (PEGDA), Poly(N-isopropylacrylamide) (PNIPAm), and dextran, and demonstrates their dynamic shrinking, swelling, and movement responses to temperature changes, suggesting potential applications in targeted drug delivery and micromotor systems. 7 As the field continues to evolve, novel diverse fabrication methods underscore the potential and versatility of catalytic micromotors in various applications. 8 The galvanic replacement reaction on the surface of Ni in an H 2 PtCl 6 solution is known to be relatively well-studied and is utilized in the creation of new electrocatalysts for water electrolysis, among other applications such as catalysts.…”

mentioning

confidence: 99%

Rapid synthesis of Pt(0) motors-microscrolls on a nickel surface via H₂PtCl₆-induced galvanic replacement reaction

Tolstoy,

Nikitin,

Kuzin

et al. 2024

Chem. Commun.

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Reversible speed control of one-stimulus-double-response, temperature-sensitive asymmetric hydrogel micromotors

Abstract: Soft, one-stimulus-double-response, thermo-sensitive, PNIPAm-based microgels are designed for controlled autonomous motion under stimuli. At higher temperatures, the motors with physically encapsulated catalase move faster, while motors in which catalase is...

Cited by 4 publications

References 30 publications

Anisotropic, Hydrogel Microparticles as pH-Responsive Drug Carriers for Oral Administration of 5-FU

Anisotropic, Hydrogel Microparticles as pH-Responsive Drug Carriers for Oral Administration of 5-FU

Spatial Control over Catalyst Positioning for Increased Micromotor Efficiency

Rapid synthesis of Pt(0) motors-microscrolls on a nickel surface via H₂PtCl₆-induced galvanic replacement reaction

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Reversible speed control of one-stimulus-double-response, temperature-sensitive asymmetric hydrogel micromotors

Abstract: Soft, one-stimulus-double-response, thermo-sensitive, PNIPAm-based microgels are designed for controlled autonomous motion under stimuli. At higher temperatures, the motors with physically encapsulated catalase move faster, while motors in which catalase is...

Cited by 4 publications

References 30 publications

Anisotropic, Hydrogel Microparticles as pH-Responsive Drug Carriers for Oral Administration of 5-FU

Anisotropic, Hydrogel Microparticles as pH-Responsive Drug Carriers for Oral Administration of 5-FU

Spatial Control over Catalyst Positioning for Increased Micromotor Efficiency

Rapid synthesis of Pt(0) motors-microscrolls on a nickel surface via H2PtCl6-induced galvanic replacement reaction

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Rapid synthesis of Pt(0) motors-microscrolls on a nickel surface via H₂PtCl₆-induced galvanic replacement reaction