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AbstractPurpose -New approaches for non-classical neural-based computing are introduced. The developed approaches utilize new concepts in three-dimensionality, invertibility and reversibility to perform the required neural computing. The various implementations of the new neural circuits using the introduced paradigms and architectures are presented, several applications are shown, and the extension for the utilization in neural-systolic computing is also introduced. Design/methodology/approach -The new neural paradigms utilize new findings in computational intelligence and advanced logic synthesis to perform the functionality of the basic neural network (NN). This includes the techniques of three-dimensionality, invertibility and reversibility. The extension of implementation to neural-systolic computing using the introduced reversible neural-systolic architecture is also presented. Findings -Novel NN paradigms are introduced in this paper. New 3D paradigm of NL circuits called three-dimensional inverted neural logic (3DINL) circuits is introduced. The new 3D architecture inverts the inputs and weights in the standard neural architecture: inputs become bases on internal interconnects, and weights become leaves of the network. New reversible neural network (RevNN) architecture is also introduced, and a RevNN paradigm using supervised learning is presented. The applications of RevNN to multiple-output feedforward discrete plant control and to reversible neural-systolic computing are also shown. Reversible neural paradigm that includes reversible neural architecture utilizing the extended mapping technique with an application to the reversible solution of the maze problem using the reversible counterpropagation NN is introduced, and new neural paradigm of reversibility in both architecture and training using reversibility in independent component analysis is also presented. Originality/value -Since the new 3D NNs can be useful as a possible optimal design choice for compacting a learning (trainable) circuit in 3D space, and because reversibility is essential in the minimal-power computing as the reduction of power consumption is a main requirement for the circuit synthesis of several eme...