REVIEW: Adult Celiac Disease and the Severe “Flat” Small Bowel Biopsy Lesion

Freeman, Hugh James

doi:10.1023/b:ddas.0000026295.64670.d1

Cited by 17 publications

(3 citation statements)

References 86 publications

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“…Celiac Sprue.-In fully developed sprue, the small-bowel mucosa is completely flat, with a very cellular lamina propria and regenerative epithelium, 29 all features that are also found in OAE. There is prominent surface epithelial lymphocytosis, more striking than in most cases of OAE, and cytoplasmic lipid droplets are often present in the surface epithelium (Figure 9).…”

Section: Differential Diagnosismentioning

confidence: 99%

Olmesartan-Associated Enteropathy: A Review of Clinical and Histologic Findings

Choi

McKenna²

2015

Archives of Pathology &Amp; Laboratory Medicine

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Olmesartan is an antihypertensive medication belonging to the angiotensin II receptor blocker class of drugs that has recently been associated with severe enteropathy. Olmesartan-associated enteropathy is uncommon and may be difficult to recognize because of its clinical and histologic similarities to other clinical entities, including celiac sprue and autoimmune enteropathy. The purpose of this article is to review the clinical and histologic findings of olmesartan-associated enteropathy that have been reported in the literature and to discuss clinical entities to consider in the differential diagnosis of olmesartanassociated enteropathy.

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Section: Differential Diagnosismentioning

confidence: 99%

Olmesartan-Associated Enteropathy: A Review of Clinical and Histologic Findings

Choi

McKenna²

2015

Archives of Pathology &Amp; Laboratory Medicine

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“…Small-bowel biopsies are obtained during esophago-gastroscopy, and according to current diagnostic criteria, the detection of small-bowel mucosal villous atrophy and crypt hyperplasia is mandatory for the diagnosis [72]. Unfortunately, there are pitfalls in this approach [73,74]; the presence of villous atrophy is not pathognomonic for celiac disease alone [75], and further, celiac disease causes a continuum of intestinal alterations starting from increased densities of intraepithelial lymphocytes and only eventually leading to flat mucosa [76], and celiac disease symptoms and even complications can be present even before the development of marked villous atrophy [77,78]. Intraepithelial lymphocytosis, albeit an early marker of celiac development, is also known to be unspecific for the disease [79]; an increased density of γδ intraepithelial cells detected in frozen small-bowel samples is indicative of celiac disease but not entirely restricted to celiac inflammation [80].…”

Section: Diagnosing Celiac Diseasementioning

confidence: 99%

Transglutaminase 2 and Transglutaminase 2 Autoantibodies in Celiac Disease: a Review

Rauhavirta

Hietikko

Salmi

et al. 2016

Clinic Rev Allerg Immunol

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Celiac disease is a common inflammatory disorder with a prevalence of 1-2 % in which a distinct dietary wheat, rye, and barley component, gluten, induces small-bowel mucosal villous atrophy, crypt hyperplasia, and inflammation. The small-bowel mucosal damage can be reversed by a strict lifelong gluten-free diet, which is currently the only effective treatment for the condition. A key player in the pathogenetic process leading to the enteropathy is played by a protein called transglutaminase 2 (TG2), which is able to enzymatically modify gluten-derived gliadin peptides. The TG2-catalyzed deamidation of the gliadin peptides results in their increased binding affinity to the disease-predisposing human leukocyte antigen (HLA) DQ2 and DQ8 molecules, thus enabling a strong immune response to be launched. Blocking the enzymatic activity of TG2 has thus been suggested as a suitable novel pharmacological approach to treat celiac disease. By virtue of its transamidation capacity, TG2 is also able to cross-link gliadin peptides to itself, this resulting in the generation of TG2-gliadin peptide complexes whose presence might provide an explanation for the generation of the TG2 autoantibodies characteristic of celiac disease. Due to their excellent specificity for the disorder, the TG2-targeted autoantibodies are widely used in the diagnostics as a first-line test to select patients for gastrointestinal endoscopy. More recently, it has come to be appreciated that these autoantibodies and also the TG2-specific B cells might play an active role in the disease pathogenesis. In this review, we assess the role of TG2, TG2-specific B cells, and autoantibodies in celiac disease.

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“…Dentro de estas pruebas encontramos los marcadores genéticos de riesgo, que permiten detectar la susceptibilidad genética basada en el haplotipo HLA, así como los anticuerpos antiendomisio, anticuerpos antitransglutaminasa tisular y anticuerpos antigliadina (50). Sin embargo, la biopsia endoscópica del intestino delgado sigue constituyendo la clave diagnóstica de la EC (51). La muestra duodenal de los pacientes celiacos se caracteriza por presentar linfocitosis intraepitelial, hiperplasia de criptas y atrofia vellositaria (Figura 1).…”

Section: 2-clínica Y Diagnóstico De La Enfermedad Celiacaunclassified

Estudio de la actividad metabólica de la microbiota intestinal asociada al consumo de gluten en humanos = Study of the metabolic activity of the intestinal microbiota associated with gluten intake in humans

Fernandez¹

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VIVAS ALEGRE como directores de la Tesis Doctoral titulada "Estudio de la actividad metabólica de la microbiota intestinal asociada al consumo de gluten en humanos" realizada por D. ALBERTO CAMINERO FERNÁNDEZ, en el programa de doctorado BIOLOGÍA MOLECULAR Y BIOTECNOLOGÍA, informan favorablemente el depósito de la misma, dado que reúne las condiciones necesarias para su defensa.Lo que firman, para dar cumplimiento al art. 11.3 del R.D. 56/2005, en León a ___ de mayo de 2013. Los directores de la Tesis DoctoralEl órgano responsable del programa de doctorado de BIOLOGÍA MOLECULAR Y BIOTECNOLOGÍA en su reunión celebrada el día _______ de 2013 ha acordado dar su conformidad a la admisión a trámite de lectura de la Tesis Doctoral titulada: "Estudio de la actividad metabólica de la microbiota intestinal asociada al consumo de gluten en humanos", dirigida por el Dr. , cuyo título en inglés es:"Study of the metabolic activity of the intestinal microbiota associated with gluten intake in humans".Lo que firmo, para dar cumplimiento al art. 11.3 del R.D. 56/2005, en León a _____ de mayo de 2013. A mi familiaQuien tiene un porqué para vivir Puede enfrentarse a todos los cómos Viktor Frankl AGRADECIMIENTOS Un trabajo como este sólo adquiere auténtico valor cuando permite agradecer a todas las personas que, de una manera u otra, han apoyado a su realización durante estos años. Muchas son las personas que han participado con su esfuerzo y su confianza en la elaboración de esta Tesis Doctoral. A ellas les quiero agradecer. En primer lugar, al Dr. Javier Casqueiro Blanco, director de esta Tesis y principalmente amigo. Gracias por darme la primera oportunidad, la más difícil. Gracias por tus consejos, tus ideas y los Tés con limón los días de desamparo científico. Me guardo muchas de tus lecciones para mi futuro. Ha sido un placer haber descubierto el mundo de la celiaca de tu mano. En segundo lugar quiero agradecer al Dr. Santiago Vivas, co-director de esta Tesis Doctoral, y a José María Ruiz de Morales, "tri-director de Tesis", si se me permite el nuevo concepto. Ha sido muy grato para mí haber disfrutado de vuestra experiencia. Gracias por estar siempre disponibles y por vuestra ayuda constante. A mis compañeras de laboratorio. A Esther por ser "mi becaria mayor", dar conmigo los primeros pasos científicos y por ayudarme tanto. Quiero agradecer tu esfuerzo y amistad durante estos años, y darte la enhorabuena por tu nueva etapa en la vida. A Sandra, compi de laboratorio y hombro en el que llorar en mis eventuales fracasos experimentales. Siento haberte estropeado los bolis. Quiero que sepas, que no fui capaz de reemplazarte por la caja de cartón durante tu estancia. A Jenifer, la última integrante del grupo. Gracias por tu importante trabajo sucio en esta Tesis Doctoral durante mi ascenso a quasi-doctor. Creo que el futuro de mis bichos está en las mejores manos posibles. También quiero agradecer a otros actores secundarios como Ana, María, Lara, que ayudaron al trabajo experimental de esta Tesis. Una mención muy especial, e imp...

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REVIEW: Adult Celiac Disease and the Severe “Flat” Small Bowel Biopsy Lesion

Cited by 17 publications

References 86 publications

Olmesartan-Associated Enteropathy: A Review of Clinical and Histologic Findings

Olmesartan-Associated Enteropathy: A Review of Clinical and Histologic Findings

Transglutaminase 2 and Transglutaminase 2 Autoantibodies in Celiac Disease: a Review

Estudio de la actividad metabólica de la microbiota intestinal asociada al consumo de gluten en humanos = Study of the metabolic activity of the intestinal microbiota associated with gluten intake in humans

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