Review and Current Status of Opisthorchis viverrini Infection at the Community Level in Thailand

Kaewpitoon, Natthawut; Kootanavanichpong, Nusorn; Kompor, Ponthip; Chavenkun, Wasugree; Kujapun, Jirawoot; Norkaew, Jun; Ponphimai, Sukanya; Matrakool, Likit; Tongtawee, Taweesak; Panpimanmas, Sukij; Rujirakul, Ratana; Padchasuwan, Natnapa; Pholsripradit, Poowadol; Eksanti, Thawatchai; Phatisena, Tanida; Loyd, Ryan A; Kaewpitoon, Soraya J

doi:10.7314/apjcp.2015.16.16.6825

Cited by 30 publications

(13 citation statements)

References 27 publications

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“…Chronic infection caused by the Southeast Asian liver fl uke (Opisthorchis viverrini) is a critical risk factor for the development of the bile duct cancer cholangiocarcinoma (CCA), what is a major health concern in South-East Asia (Thailand, Laos People's Democratic Republic, Cambodia and central Vietnam) Aunpromma et al, 2012;Miyamoto et al, 2014;Kaewpitoon et al, 2015;Khuntikeo et al, 2016). In Thailand at least 6 million people are estimated to be currently infected (Andrews et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Opisthorchis viverrini in an endemic area of Thailand, an integrative approach

et al. 2017

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SummaryAn integrated epidemiological study of Opisthorchis viverrini consisting of risk factors analysis and parasitation prevalence determination in humans, as well as the assessment the roles of host reservoirs (dogs and cats) and intermediate hosts (cyprinid fi sh) was carried out in the vicinity of Huay Luang dam, Udon Thani province, in the north east of Thailand. The survey was conducted from June 2014 to July 2016 in three sub-districts. Fecal samples were collected from 5,347 participants in 22 villages and the overall prevalence of O. viverrini was found to be 31.5 %. Risk factors for liver fl uke infection were determined from questionnaires analysis which sought demographic data and information about the eating behaviors of the participants. The behavior of raw fi sh consumption correlated signifi cantly with parasitation in the studied areas. The risk factors for O. viverrini infection in humans were associated signifi cantly with age, education, and habitation within a two kilometer range from nearby water and food sources. Questionnaires showed that the drug treatments were not always appropriate. The stools of domestic dogs (n = 468) and cats (n = 262) collected for parasitological analysis and results showed that the zoonotic role of dogs should not be underestimated as has been done previously/in past. The incidence of O. viverrini metacercariae in four cyprinid fi shes Barbonymus gonionotus (n = 124), Cyclocheilichthys repasson (n = 843), Hampala dispar (n = 276) and Henicorhynchus siamensis n = 946), were determined and overall values ranged from 2.4 % to 23.1 %. There was a seasonal variation in metacercariae intensity which ranged from 1 -125 metacercariae per fi sh. The study concluded that transmission ecology should be taken into consideration in developing of control strategies against opisthorchiasis.

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Section: Introductionmentioning

confidence: 99%

Epidemiology of Opisthorchis viverrini in an endemic area of Thailand, an integrative approach

et al. 2017

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“…The mortality rate of CCA has been reported that Nakhon Ratchasima province has 13.67-16.2 per 100,000 populations (Sripa et al, 2011). In addition, Opisthorchis viverrini; the carcinogenic liver fluke, also has been reported in this province (Kaewpitoon et al, 2012c;Kaewpitoon et al, 2015). Furthermore, the infective stage of O. viverrini was found frequently coverage areas approximately 78.1% of province (Kaewpitoon et al, 2012a).…”

Section: Discussionmentioning

confidence: 95%

Distribution of the Population at Risk of Cholangiocarcinoma in Bua Yai District, Nakhon Ratchasima of Thailand Using Google Map

Kaewpitoon

Rujirakul²,

Sangkudloa³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: Cholangiocarcinoma (CCA), a major problem of health in Thailand, particularly in Northeastern and Northern regions, is generally incurable and rapidly lethal because of presentation in stage 3 or 4. Early diagnosis of stage 1 and 2 could allow better survival. Therefore, this study aimed to provide a distribution map of populations at risk for CCA in BuaYai district of Nakhon Ratchasima province, Northeast Thailand. Materials and Methods: A cross-sectional survey was carried out in 10 sub-districts and 122 villages, during June and November 2015. The populations at risk for CCA were screened using the Korat CCA verbal screening test (KCVST) and then risk areas were displayed by using Google map (GM). Results: A total of 11,435 individuals from a 26,198 population completed the KCVST. The majority had a low score of risk for CCA (1-4 points; 93.3%). High scores with 6, 7 and 8 points accounted for 1.20%, 0.13% and 0.02%. The population at risk was found frequently in sub-district municipalities, followed by sub-district administrative organization and town municipalities, (F=396.220, P-value=0.000). Distribution mapping comprised 11 layers: 1, district; 2, local administrative organization; 3, hospital; 4, KCVST opisthorchiasis; 5, KCVST praziquantel used; 6, KCVST cholelithiasis; 7, KCVST raw fish consumption; 8, KCVST alcohol consumption; 9, KCVST pesticide used; 10, KCVST relative family with CCA; and 11, KCVST naïve northeastern people. Geovisual display is now available online. Conclusions: This study indicated that the population at high risk of CCA in Bua Yai district is low, therefore setting a zero model project is possible. Key success factors for disease prevention and control need further study. GM production is suitable for further CCA surveillance and monitoring of the population with a high risk score in this area.

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“…Facilitate Health Literacy Regarding Carcinogenic Human Liver Fluke: A Randomized Controlled Trial in Thailand people are at risk of liver fluke infection (Sithithaworn et al, 2012), which has been found to have the highest prevalence in the northeast (16.6%) and north (10%) (Wongsaroj et al, 2014). The infection is frequently found in men over 35 years of age and in agricultural occupations (Kaewpitoon et al, 2015). The infection results from the consumption of raw or undercooked freshwater cyprinoid fish.…”

Section: Ovcca Web Application As Supplementary Materials Tomentioning

confidence: 99%

OVCCA Web Application as Supplementary Material to Facilitate Health Literacy Regarding Carcinogenic Human Liver Fluke: A Randomized Controlled Trial in Thailand

Wattanawong

Prachaiboon

Meererksom

et al. 2021

Asian Pac J Cancer Prev

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Background: Liver fluke, Opisthorchis viverrini, is associated to cholangiocarcinoma which is found frequently in some areas of Southeast Asian countries particularly in Thailand, Lao People Republic Democratic, Cambodia. This study sought to investigate the effects of an O. viverrini and cholangiocarcinoma (OVCCA) web application to facilitate health literacy regarding O. viverrini in Northeast Thailand. Methods: A randomized controlled trial study was performed among an intervention group (n=63) and a control group (n=63) during a one-year period from July 2019 to May 2020. The intervention group received the health literacy promotion program of O. viverrini information through the OVCCA web application for 6 weeks. The control group received an activity package from the public health department. The success of the program was evaluated at week 24 after the groups finished the last activity. ANCOVA, t-test and multiple logistic regression were used for data analysis for both groups. Results: The scores for knowledge; ability to access, understand, appraise, and apply information; motivation for protection; and practice of O. viverrini prevention were significantly higher for the intervention group than for the control group. The results indicated that a health literacy promotion program through an OVCCA web application could be advantageous for preventing and controlling O. viverrini infection. Conclusion: This intervention may be used as a potential strategy and guideline for self-care and health promotion in other endemic areas.

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Review and Current Status of Opisthorchis viverrini Infection at the Community Level in Thailand

Cited by 30 publications

References 27 publications

Epidemiology of Opisthorchis viverrini in an endemic area of Thailand, an integrative approach

Epidemiology of Opisthorchis viverrini in an endemic area of Thailand, an integrative approach

Distribution of the Population at Risk of Cholangiocarcinoma in Bua Yai District, Nakhon Ratchasima of Thailand Using Google Map

OVCCA Web Application as Supplementary Material to Facilitate Health Literacy Regarding Carcinogenic Human Liver Fluke: A Randomized Controlled Trial in Thailand

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