Dust pollution in open-pit coal mines severely restricts the green development of mines. Therefore, dust control has become an important requirement for the sustainable development of the mining industry. With the goal of dust pollution prevention and control in open-pit coal mines, this paper puts forward the concept of a non-disturbance area of an open-pit coal mine. It clarifies the characteristics of dust generation, the coverage area, and the dust particle size distribution characteristics of the non-disturbance area. Taking the dust control at the dump site as an example, the study comprehensively utilizes indoor tests and field tests to develop a dust suppressant for the dump site and determine its dust suppression efficiency and effective service cycle. The results show that the D10, D50, and D90 particle sizes of dust in the non-disturbance area are smaller than those in the disturbance area, and the difference in particle size of D90 is the most obvious. Gelatinized starch and non-ionic polyacrylamide, as the main components of the dust suppressant, can effectively reduce dust pollution in the dump; the optimal concentration is 1.0%, and the dust suppression service cycle is more than one month. The developed dust suppressant does not contain corrosive, toxic, or heavy metal elements. Although the application of a dust suppressant will cause plant growth to lag, it does not affect plant health. The research findings serve as a reference for the zoning treatment of dust in open-pit mines.