2D transition metal carbides or nitrides, known as MXenes, are a new family of 2D materials with close to 30 members experimentally synthesized and dozens more theoretically investigated. Because of the abundant surface terminations, MXenes have been compounded with various materials by multi-interactions. In addition to the prevented aggregation and oxidation of MXene flakes, the MXene/polymer membranes exhibit outstanding mechanical, thermal, and electrical properties due to the synergistic effects. However, relatively little is currently known about the MXene/polymer membranes and a special review on the progress of the synthesis, properties, and applications of MXene/polymer membranes has not been reported to date. Herein, this Review starts with an introduction of the synthesis and properties of MXenes. Then the development of MXene/polymer membranes will be discussed, which aims to summarize various approaches of fabricating MXene/polymer membranes and their fascinating properties. The focus then turns to their exciting potential applications in various fields such as filtration, electromagnetic interference (EMI) shielding, energy storage devices, wearable electronics, etc. Finally, outlooks and perspectives for the future challenges and prospects of MXene/polymer membranes are provided.