REVIEW ARTICLE: Control of Interferon‐Tau Expression During Early Pregnancy in Ruminants

Ealy, Alan D.; Yang, Qi-En

doi:10.1111/j.1600-0897.2008.00673.x

Cited by 81 publications

(67 citation statements)

References 114 publications

(269 reference statements)

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“…The outcome of the progesteroneinduced changes in the uterus during the estrous cycle or pregnancy is to modify the intrauterine milieu, such as an increase in select amino acids, glucose, cytokines and growth factors, and adhesion proteins in histotroph, for support of blastocyst growth into an ovoid conceptus and its elongation to form a fi lamentous conceptus (see Spencer et al 2008 ;Bazer et al 2010 ;Forde and Lonergan 2012 ;Dorniak et al 2013 ;. Factors from the endometrium may also stimulate the expression of IFNT in the conceptus trophectoderm (Roberts et al 2003 ;Michael et al 2006 ;Ealy and Yang 2009 ;Kim et al 2011 ). Several recent reviews catalogue the endometrial contributions to uterine luminal fl uid that functions in conceptus elongation in ruminants (Roberts et al 2008 ;Spencer et al 2008 ;Bazer et al 2010 ;Forde and Lonergan 2012 ;Bauersachs and Wolf 2013 ;Dorniak et al 2013 ;Ulbrich et al 2013 ;Lonergan and Forde 2014 ).…”

Section: Embryotrophic Factors In the Uterine Lumen Regulating Concepmentioning

confidence: 97%

Implantation and Establishment of Pregnancy in Ruminants

Spencer

Hansen

2015

Advances in Anatomy, Embryology and Cell Biology

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The establishment of pregnancy in ruminants occurs during the peri-implantation period and involves the suppression of the endometrial luteolytic mechanism to maintain progesterone production by the corpus luteum (CL). Reciprocal interactions between the elongating conceptus (embryo/fetus and associated extraembryonic membranes) and endometrium culminate in implantation. Antiluteolytic effects of the conceptus are due to the production of interferon tau (IFNT) by the trophoblast that has a paracrine effect to inhibit the upregulation of oxytocin receptors in the endometrial epithelia, thereby disrupting uterine release of luteolytic prostaglandin F2 alpha (PGF) pulses. Additionally, IFNT is released into the uterine vein and has endocrine actions to induce ISGs in peripheral tissues. For example, IFNT may induce luteal resistance to PGF, thereby ensuring survival of the CL and maintenance of pregnancy. Survival of the blastocyst and elongation of the conceptus requires embryotrophic factors from the epithelia of the uterus, and those embryotrophic factors are regulated by ovarian progesterone as well as conceptus-derived factors including IFNT and prostaglandins. This review provides new concepts on mechanisms of the establishment of pregnancy and implantation in ruminants with emphasis on conceptus-maternal signaling associated with elongation of the blastocyst and endometrial responses to the presence of a conceptus.

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Section: Embryotrophic Factors In the Uterine Lumen Regulating Concepmentioning

confidence: 97%

Implantation and Establishment of Pregnancy in Ruminants

Spencer

Hansen

2015

Advances in Anatomy, Embryology and Cell Biology

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“…After reaching the blastocyst stage, they float another 2 weeks in the uterus before finally starting to attach to the endometrium at days 19 and 20 (Guillomot 1995). Trophoblast commitment may only need to be complete by day 14 when intense trophoblast proliferation begins together with increased trophoblast secretion of the ruminant pregnancy recognition factor Ifn-t (Ealy & Yang 2009). …”

Section: Commitment Of the Trophoblast Lineagementioning

confidence: 99%

Trophoblast development

Pfeffer¹,

Pearton²

2012

Reproduction

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This review summarises current knowledge about the specification, commitment and maintenance of the trophoblast lineage in mice and cattle. Results from gene expression studies, in vivo loss-of-function models and in vitro systems using trophoblast and embryonic stem cells have been assimilated into a model seeking to explain trophoblast ontogeny via gene regulatory networks. While trophoblast differentiation is quite distinct between cattle and mice, as would be expected from their different modes of implantation, recent studies have demonstrated that differences arise much earlier during trophoblast development.

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“…The unique pattern of IFNτ expression is regulated by promoter/ enhancer regions that are distinct from those of other type I IFN genes [19,20]. One key component of IFNτ expression is caudal-type homeobox 2 (CDX2), which stimulates IFNτ promoter activity in the presence of Ets-2 [21,22].…”

mentioning

confidence: 99%

“…IFNτ is a type I IFN under a unique transcriptional control that limits its expression to ruminant trophoblasts prior to implantation [1,[14][15][16]. A major role of this cytokine is to mute the pulsatile release of prostaglandin F 2α from the maternal uterine endometrium, thereby, blocking luteolysis [17,18].The unique pattern of IFNτ expression is regulated by promoter/ enhancer regions that are distinct from those of other type I IFN genes [19,20]. One key component of IFNτ expression is caudal-type homeobox 2 (CDX2), which stimulates IFNτ promoter activity in the presence of Ets-2 [21,22].…”

mentioning

confidence: 99%

Embryonic Development and Implantation Related Gene Expression of Oocyte Reconstructed with Bovine Trophoblast Cells

Saadeldin

Choi

Torre

et al. 2012

Journal of Reproduction and Development

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Abstract. The temporal progressive increase of interferon tau (IFNτ) secretion from the bovine trophoblast is a major embryonic signal of establishing pregnancy. Here, we cultured and isolated bovine trophoblast cells (BTs) from IVM/IVF oocytes and in vitro produced blastocysts, used them, for the first time, as donor cells for nuclear transfer and compared them with adult fibroblasts (AFs) as donor cells. BTs were reprogrammed in enucleated oocytes to blastocysts with similar efficiency to AFs (14.5% and 15.6% respectively, P≤0.05). The levels of IFNτ, CDX2 and OCT4 expression in IVF-, BTand AF-derived blastocysts were analyzed using reverse transcription polymerase chain reaction and reverse transcription quantitative polymerase chain reaction (RT-PCR and RT-qPCR). IVF-produced embryos were used as reference to analyze the linear progressive expression of IFNτ through mid, expanded and hatching blastocysts. RT-PCR and RT-qPCR studies showed that IFNτ expression was higher in BT-derived blastocysts than IVF-and AF-derived blastocysts. Both IVF-and BT-derived blastocysts showed a progressive increase in IFNτ expression as blastocyst development advanced when it compared with AF-derived blastocysts. OCT4 was inversely related with IFNτ expression, while CDX2 was found to be directly related with IFNτ temporal expression. Persistence of high expression of IFNτ and CDX2 was found to be higher in BT-derived embryos than in IVF-or AF-derived embryos. In conclusion, using BTs expressing IFNτ as donor cells for bovine NT could be a useful tool for understanding the IFNτ genetics and epigenetics. Key words: Bovine trophoblast, Interferon tau, Nuclear transfer, Real-time PCR, Reprogramming (J. Reprod. Dev. 58: [425][426][427][428][429][430][431] 2012) S ince the first cloned lamb was born, nuclear transfer (NT) has been challenging in several species and has produced many cloned offspring [1][2][3]. To produce cloned offspring, fetal fibroblasts have been chosen as a preferential donor cell line for NT so far because they have high proliferative potentials [4][5][6][7]. In cattle, fetal and adult fibroblasts have been dominantly used for NT to produce cloned calves. Additionally, several types of cells, like granulosa, cumulus, oviduct epithelial cells, skin, tongue and other cells, have been used for NT [8,9].After fertilization of an egg with a sperm, the one-cell stage embryo grow up through several mitosis and reaches the preimplantation stage, becoming a blastocyst, which consists of an inner cell mass (ICM) that is capable of differentiation into all embryo organs and trophoblasts, which are the first differentiated cells from the embryo, and contributes formation of the placenta and fetal membranes but does not participate the formation of the fetus proper [7]. Some reports have demonstrated trophoblast isolation and its function in vitro in cattle [10][11][12]. In mice, living pups were born by nuclear transfer of trophectoderm cells from the expanded blastocysts into enucleated oocytes [13] as a trial to show...

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REVIEW ARTICLE: Control of Interferon‐Tau Expression During Early Pregnancy in Ruminants

Abstract: Although understanding the regulation of IFNT expression is far from complete, considerable progress has been made in uncovering how uterine-derived factors and key placental-specific transcriptional regulators control IFNT expression.

Cited by 81 publications

References 114 publications

Implantation and Establishment of Pregnancy in Ruminants

Implantation and Establishment of Pregnancy in Ruminants

Trophoblast development

Embryonic Development and Implantation Related Gene Expression of Oocyte Reconstructed with Bovine Trophoblast Cells

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