Review article on Chemical constituents and Biological activity of Thymelaea hirsuta

Badawy, Ahmed

doi:10.21608/rpbs.2019.11644.1029

Cited by 4 publications

(5 citation statements)

References 15 publications

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Section: Resultsmentioning

confidence: 77%

“…The number of leukocytes attracted to the air-induced cavity after the carrageenan injection alone was 6 × 10 5 cells/mL higher than the number of leukocytes found in the group treated with the anti-inflammatory drug diclofenac (4.5 × 10 5 cells/mL) or in the group treated with the NPs (3.5 × 10 5 cells/mL), as shown in Figure 8. 59,60 Reduction of Adjuvant Arthritis-Induced Paw Edema. Preinjection of CuO-NPs revealed that compared to the control group, it was possible to reduce paw edema in rats by administering the treatment for a total of 21 days.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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In Vivo Analgesic, Anti-Inflammatory, and Anti-Diabetic Screening of Bacopa monnieri-Synthesized Copper Oxide Nanoparticles

et al. 2022

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In this work, an ecofriendly approach for biogenic production of copper oxide nanoparticles (CuO-NPs) was proposed by utilizing the Bacopa monnieri leaf extract as a reducing and stabilizing agent. The synthesis of CuO-NPs was instantly confirmed by a shift in the color of the copper solution from blue to dark gray. The use of UV−visible spectroscopy revealed a strong narrow peak at 535 nm, confirming the existence of monoclinic-shaped nanoparticles. The average size of CuO-NPs was 34.4 nm, according to scanning electron microscopy and transmission electron microscopy studies. The pristine crystalline nature of CuO-NPs was confirmed by X-ray diffraction. The monoclinic form of CuO-NPs with a crystallite size of 22 nm was determined by the sharp narrow peaks corresponding to 273, 541, 698, 684, and 366 Bragg's planes at different 2θ values. The presence of different reducing metabolites on the surface of CuO was shown by Fourier transform infrared analysis. The biological efficacy of CuO-NPs was tested against Helicobacter felis, Helicobacter suis, Helicobacter salomonis. and Helicobacter bizzozeronii. H. suis was the most susceptible strain with an inhibition zone of 15.84 ± 0.89 mm at 5 mg/mL of NPs, while the most tolerant strain was H. bizzozeronii with a 13.11 ± 0.83 mm of inhibition zone. In in vivo analgesic activity, CuO-NPs showed superior efficiency compared to controls. The maximum latency time observed was 7.14 ± 0.12 s at a dose level of 400 mg/kg after 90 min, followed by 5.21 ± 0.29 s at 400 mg/kg after 60 min, demonstrating 65 and 61% of analgesia, respectively. Diclofenac sodium was used as a standard with a latency time of 8.6 ± 0.23 s. The results observed in the rat paw edema assays showed a significant inhibitory activity of the plant-mediated CuO-NPs. The percentage inhibition of edema was 74% after 48 h for the group treated with CuO-NPs compared to the control group treated with diclofenac (100 mg/kg) with 24% edema inhibition. The solution of CuO-NPs produced 82% inhibition of edema after 21 days when compared with that of the standard drug diclofenac (73%). CuO-NPs vividly lowered glucose levels in STZ-induced diabetic mice, according to our findings. Blood glucose levels were reduced by about 33.66 and 32.19% in CuO-NP and (CuO-NP + insulin) groups of mice, respectively. From the abovementioned calculations, we can easily conclude that B. monnieri-synthesized CuO-NPs will be a potential antibacterial, anti-diabetic, and anti-inflammatory agent on in vivo and in vitro basis.

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Section: Resultsmentioning

confidence: 77%

Section: ■ Results and Discussionmentioning

confidence: 99%

In Vivo Analgesic, Anti-Inflammatory, and Anti-Diabetic Screening of Bacopa monnieri-Synthesized Copper Oxide Nanoparticles

et al. 2022

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“…(Shao et al, 2013) reported that application of 0.05 g/mL aqueous extract of whole P. harmala plant greatly suppressed growth of wheat and lettuce seedling, indicating the presence of active phytotoxins in this plant. Also, there were significant differences between plant extracts on vegetative growth, where T. hirsute recorded the highest value in most characters, this may be due to T. hirsuta extracts are rich sources of natural antioxidants which appears to be an alternative to synthetic antioxidants which reflected on growth of plants (Amari et al, 2014 andBadawya et al 2019).…”

Section: Effect Of Biofertilizers Treatments and Some Sinai's Flora Extracts On Vegetative Growth Of Faba Bean Plantmentioning

confidence: 96%

Effect of Biofertilization and Some Sinai’s Flora Extracts on the Vegetative Growth and Yield of Broad Bean

Mansour¹,

Bolok²,

Mansy³

2021

PLANT ARCHIVES

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Broad bean plants (Vicia faba L.) were cultivated in two field experiments at the Experimental Station of the Faculty of Environmental Agricultural Sciences, Arish University, North Sinai, Egypt, during 2018/2019 and 2019/2020 seasons under North Sinai condition, to study the effect of soil application of some biofertilizers and foliar spray with some wild plant extracts on broad bean plants. Biofertilizer treatments contained combination of Arbuscular Mycorrhizal Fungi (AMF) + Trichoderma harzianum + Rhizobium leguminosarum. Three wild plant extracts treatments; i.e., Qeysoom Gebeli (Achillea fragrantissima L.), Harmal (Peganum harmala L.) and Mitnaan (Thymelaea hirsute L.) were sprayed on plants. Treatments were arranged in a randomized complete block design with three replicates in split plot system. The results indicated that biofertilizers had significant effected of all studied traits in both seasons. Foliar spraying of Thymelaea hirsute extract had the highest stimulation effects on spores count, root colonization, mycorrhizal status, and weight of non-active nodules, broad bean plant growth characters; i.e. stem length, number of branches per plant, leaf area, and shoot fresh and dry weight as well as both of fresh and dry weight of roots. Both of Thymelaea hirsute and Achillea fragrantissima extracts combined with biofertilizer treatment had significant effects on yield and its components (pod length, number of pods per plant, average pod weight total yield per plant, and weight of seeds per pod) in both seasons. The combination between Thymelaea hirsute and biofertilizer was the superior interaction treatment of this study.

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“…Additionally, Bedouins have recruited powdered Thymelaea hirsuta in their traditional veterinary medicine to prevent miscarriages in she-camels [ 17 ]. Generally, steroidal compounds, flavonoids, coumarins, and lignans are the active chemical constituents that play a role in biological activity [ 19 ]. The Thymelaea hirsuta aqueous extracts are highly active sources of natural antioxidants, which play an essential role in controlling various pathological conditions, such as Parkinson’s disease and Alzheimer’s disease [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

DNA Barcoding of Two Thymelaeaceae Species: Daphne mucronata Royle and Thymelaea hirsuta (L.) Endl

Alkaraki

Aldmoor

Lahham

et al. 2021

Plants

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Daphne mucronata Royle and Thymelaea hirsuta (L.) Endl both belong to the Thymelaeaceae family. Both species are used traditionally to treat several diseases along with various daily applications by Jordanian Bedouins. Traditionally, those species are identified through personal proficiency, which could be misleading due to human errors or lack of expertise. This study aims to investigate an effective DNA barcoding method to identify and characterize Daphne mucronata Royle and Thymelaea hirsuta plant species at the molecular level. Daphne mucronata Royle and Thymelaea hirsuta were collected from the ancient city of Petra in the Southern part of Jordan. Sequences of candidate DNA barcodes were amplified (rbcL, matK, and rpoC1), sequenced, and aligned to the blastn database. Moreover, the obtained sequences were compared with available sequences of related species at the GenBank database. Our results showed that DNA barcoding successfully identifies the two plant species using any of chloroplast genes (rbcL, matK, or rpoC1). The results emphasize the ability of DNA barcoding for identifying and characterizing different plant species through the recruitment of different barcode loci in molecular identification.

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Review article on Chemical constituents and Biological activity of Thymelaea hirsuta

Cited by 4 publications

References 15 publications

In Vivo Analgesic, Anti-Inflammatory, and Anti-Diabetic Screening of Bacopa monnieri-Synthesized Copper Oxide Nanoparticles

In Vivo Analgesic, Anti-Inflammatory, and Anti-Diabetic Screening of Bacopa monnieri-Synthesized Copper Oxide Nanoparticles

Effect of Biofertilization and Some Sinai’s Flora Extracts on the Vegetative Growth and Yield of Broad Bean

DNA Barcoding of Two Thymelaeaceae Species: Daphne mucronata Royle and Thymelaea hirsuta (L.) Endl

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