Review article on Thalassemia

Abstract

Thalassemia is a hereditary blood disorder which is passed down through families in which the body makes an abnormal form of hemoglobin. This disorder results in the destruction of red blood cell in large number, which leads to anemia. It is caused by mutation in the DNA of cells that make hemoglobin. Thalassemia should be prevented by premarital screening and prenatal diagnosis which is helpful in decreasing prevalence and future incidence of thalassemia. The most important problem in thalassemia patients are iron overload, cardiac arrhythmia, hepatitis, osteoporosis and endocrine disorder however there are typical signs and symptoms of anemia. People with thalassemia can get treatment as indicated by the degree of seriousness of their condition. Blood transfusion is the common treatment for thalassemia. This review presents the types, diagnosis, prevalence, complications and treatment of thalassemia.

Investigation of the Relationship between Thalassemia and Depression to Predict a Base for Rehabilitation Measures

“…In addition, the chronic nature of thalassemia and its potential complications can contribute to emotional distress, potentially culminating in conditions such as depression. In severe cases, thalassemia can further exacerbate symptoms such as an enlarged liver or heart, dark urine, pale skin, and poor appetite, highlighting the complicated relationship between thalassemia, disability, and mental health issues (Iqbal and Sajjad, 2021) If we look at the psychosocial aspect of these patients' lives, we can also identify disorders in this area. Symptoms such as poor self-image due to physical problems, stunted growth, pale skin, and frequent illnesses make them feel inferior to their peers, sometimes leading to bullying, which in turn leads to isolation, few friends, and avoidance of social interaction.…”