Review Article: URIC ACID HOMEOSTASIS AND DISTURBANCES

Karwur, Ferry Fredy; Pujiastuti, Dwi Rahayu

doi:10.20473/fmi.v53i4.7164

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…Uric acid (C5H4N4O3) is the end product of the catabolism of purines. It is mainly synthesized in the liver, intestine, kidneys, muscles, and vascular endothelium and eliminated by the kidneys and intestines [ 11 ]. It exhibits the properties of pro-oxidants and antioxidants.…”

Section: Reviewmentioning

confidence: 99%

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Role of Uric Acid Levels in the Development of Gestational Diabetes Mellitus: A Review

Khan¹,

Kauser²,

Palakeel³

et al. 2022

Cureus

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Gestational diabetes mellitus (GDM) is a common disorder affecting pregnancy. Besides conventional risk factors, several novel risk factors have been linked to causing GDM. Increased serum uric acid levels, also termed hyperuricemia, are regarded as one of the significant risk factors for increased insulin resistance and GDM, causing detrimental impacts on both mother and child. The likelihood of developing GDM is at its peak during the first three months of pregnancy in patients with hyperuricemia. Still, its pathophysiology needs to be evaluated in detail. This review is aimed at assessing the function of hyperuricemia in the development of GDM.

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Section: Reviewmentioning

confidence: 99%

“…Increased renal excretion and the uricosuric impact of elevated estrogen levels during pregnancy contribute to decreased levels of serum uric acid [ 11 ]. Clearance of uric acid is accelerated in pregnancy, from 6 to 12 mL/min to 12 to 20 mL/min, causing a 25% reduction in blood concentration.…”

Section: Reviewmentioning

confidence: 99%

Role of Uric Acid Levels in the Development of Gestational Diabetes Mellitus: A Review

Khan¹,

Kauser²,

Palakeel³

et al. 2022

Cureus

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“…Namun, seringkali kadar asam urat dapat melebihi Batasan normal karena pengaruh dari faktor eksogen, endogen, dan ekskresi asam urat. Eksresi asam urat merupakan faktor penting dalam menjaga keseimbangan kadar asam urat tubuh (Karwur & Pujiastuti, 2017).…”

Section: Goutunclassified

Literatur Review: Peran konseling gizi dan senam ergonomik dalam menurunkan kadar asam urat pada penderita gout

Susanti¹,

Astuti²,

Mashar³

2022

Aceh. Nutri. J.

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Gout is a disorder caused by inflammation of the joints due to the deposition of uric acid crystals stored in the joints. The causative factors are age, excessive purine intake, obesity, alcoholic beverages, and lack of physical activity. Various efforts can be made to overcome this, including nutritional counseling and physical activity, such as gymnastics. The study aims to provide descriptive information regarding the effect of nutritional counseling on a low-purine diet and ergonomic gymnastics in reducing uric acid levels in patients with gout. Literature review research was conducted using the keywords "Counseling, Ergonomic Exercise, Uric acid, and Gout" on the Google Scholar search engine and other electronic databases, namely Proquest, BMC, and Cochrane review. Scientific articles are published in national and international journals that can be accessed openly, published between 2010-2020. From these results, 13 articles were selected for review. The literature review was conducted in an unsystematic narrative review. The results of the study state that providing counseling using various media can be one solution to help reduce pain and reduce one's uric acid levels, namely through counseling or nutrition counseling and ergonomic exercises. Counseling can provide insight or knowledge related to a low-purine diet, while ergonomic exercises provide the impact of physical fitness on the patient's health. The combination of providing nutritional counseling and ergonomic exercises can reduce uric acid levels in patients with gout.

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