Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan Toksisitas

Liem, Steffi; Levita, Jutti

doi:10.22487/j24428744.0.v0.i0.8610

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…Increased levels of SGPT and SGOT indicate acetaminophen-induced liver tissue toxicity. Selection of acetaminophen doses that can induce hepatotoxic events based on some scientific literature of similar hepatoprotector studies in rat test animals with minor modifications [26][27][28]. This finding is in line with Olaleye et al (2010) who reported that SGPT and SGOT are specific biochemical parameters for detecting liver damage or injury.…”

Section: Biochemical Resultssupporting

confidence: 62%

The hepatoprotective effect of Marchantia paleacea bertol. extract against acetaminophen-induced liver damage in rat: biochemical and histological evidence

PURKON¹,

KUSMIYATI²,

TRINOVANI³

et al. 2022

jrp

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Hepatoprotectors are compounds or substances that have efficacy to protect liver cells against toxic substances result in liver damage. Liver damage caused by various factors, such as: viruses, bacteria, drugs that directly damage liver cells (such as acetaminophen, etc.), hypersensitivity reactions, hepatotoxic chemicals, toxins in food and pollution. Therefore, the development of the drug is still being tested to obtain more satisfactory results in terms of efficacy and the minimal side effects it causes. Until now, there has been no research on the hepatoprotector effect of the liverwort herbs ethanol extract of Marchantia paleacea Bertol. in a hepatotoxic-induced test animal model, especially with acetaminophen in rats. This study aimed to examine the potential hepatoprotector of the herbal liverworts extract of Marchantia paleacea Bertol. compare to Curcuma FCT ® . The hepatoprotector effect was determined by examining the biochemical levels of SGPT and SGOT, the percentage of liver index (% w/w) and histopathological feature of the liver. The increase in SGPT and SGOT levels in the liver tissue induced by acetaminophen to prove the toxicity of the liver tissue caused by acetaminophen. Marchantia paleacea Bertol ethanol extract with doses of 26 and 104 mg/kg bw in the measurement of serum levels of SGPT, SGOT, and liver index (% w/w) has shown decreased serum levels of SGPT, SGOT, and liver index (% w/w). In addition, the histological examination for scoring liver cell repair using the Manja Roenigk Histopathology Scoring Model method has shown a repair score for acetaminophen-induced liver tissue damage at both doses of the test extract (26 and 104 mg/kg bw). These findings suggest that 26 and 104 mg/kg bw have a potential protective effect on liver function against hepatotoxicity in rat livers. Thus, Marchantia paleacea Bertol. liverwort herb has great potential as a nutraceutical product, supplement, or traditional medicine that has hepatoprotective therapeutic efficacy.

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Section: Biochemical Resultssupporting

confidence: 62%

The hepatoprotective effect of Marchantia paleacea bertol. extract against acetaminophen-induced liver damage in rat: biochemical and histological evidence

PURKON¹,

KUSMIYATI²,

TRINOVANI³

et al. 2022

jrp

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“…This indicates that the food bar can protect the liver and reduce the release of SGPT and SGOT. The compounds with antioxidant properties in the extract can stabilize free radicals and prevent cell membrane damage [37].…”

Section: Sgpt and Sgot Enzyme Activitiesmentioning

confidence: 99%

The Potential of Purple Sweet Potato-based Food Bar as an Immunomodulator and Hepatoprotector Against Diethylnitrosamine-induced Mice

Widyaningsih,

Sujuti,

Fibrianto

et al. 2024

Trends Sci

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The food bar’s effect as an immunomodulator and hepatoprotector in vivo was tested on male BALB/c mice induced with diethylnitrosamine (DEN). The experimental animals were treated using the Post-test Control Group Design method. Six groups of 30 mice each made up the sample: The negative control group of healthy mice fed with a normal diet (P0); the group of healthy mice given the food bar (P1); the positive control group of mice induced with DEN and given a normal diet (P2); the group of mice induced with DEN and given a normal diet + food bar at 11,700 mg/kg (P3); the group of mice induced with DEN and given a normal diet + food bar at 23,400 mg/kg (P4); and the group of mice induced with DEN given the food bar (P5). The observations conducted included the spleen, which was used for the analysis of immunomodulators on T CD4+CD25+, CD4+, and CD8+ cells with cytokines TNF-α, IFN-Ɣ, and IL-10, blood serum for the analysis of SGPT and SGOT, and liver organ for the analysis of SOD, MDA, and histopathology. The results of the immunomodulator testing showed that the administration of the food bar (P5) significantly (p < 0.05) resulted in the highest percentage of CD4+ T cells at 2.93 % and CD8+ T cells at 5.30 %, a lower percentage of CD8+ T cells expressing proinflammatory cytokines (TNF-α at 0.27 % and IFN-γ at 0.29 %), a higher percentage of CD4+ T cells expressing CD25+, and CD25+ T cells expressing anti-inflammatory cytokines (IL-10) at 2.83 %. This group also exhibited the lowest levels of SGPT and SGOT, a higher percentage of SOD, and a lower percentage of MDA compared to other groups. The food bar, based on the mix of purple sweet potato, mung beans, moringa leaves, and strawberries, also reduced liver damage, as demonstrated through histopathological testing. HIGHLIGHTS Food bar demonstrated effectiveness as an immunomodulator by increasing CD4+ and CD8+ T-cell populations, enhancing CD4+ T-cells expressing CD25+, elevating CD25+ expressing anti-inflammatory cytokine (IL-10), and reducing CD8+ T-cells suppressing the expression of proinflammatory cytokines (TNF-α and IFN-γ) in the spleens of DEN-induced mice The provision of the food bar as the main diet resulted in reduced levels of SGPT, SGOT, and hepatic MDA in DEN-induced mice and increased SOD activity in mice induced with 50 mg/kg of DEN Food bar based on purple sweet potato, green beans, moringa leaves, and strawberries was able to protect and reduce liver cell damage caused by DEN, as demonstrated by histopathology tests GRAPHICAL ABSTRACT

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“…8,9 A hepatoprotector is a substance that functions to protect the liver from damage while restoring damage to the liver. [1][2][3][4][5][6]10 Previous research results showed that various plants that have the property to maintain liver function, including Hibiscus sabdariffa 11 , Eurycoma longifolia Jack. 1 , and Pithecellobium lobatum Benth.…”

Section: Introductionmentioning

confidence: 99%

Ethno-Medicinal Plants Used for Medication of Jaundice by The Chinese, Dayak, and Malays Ethnic in West Kalimantan, Indonesia

Panjaitan¹,

Wang²,

Yuliana³

2021

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As in Indonesia 12 , many other countries in the world also use plants in medicine, including Malaysia 15-17 , the Philippines 18,19 , Thailand, China 20 , Korea 21 , Iran 4 , and India. 2,5,22 Overall, it is stated that medicinal plants generally have lower side effects when compared to synthetic drugs. 7,23,24 West Kalimantan is one of the provinces in Indonesia, which is located on Kalimantan Island. The area of West Kalimantan, which is mostly low lying land, is around 146,807 km2. West Kalimantan consists of 12 districts namely Kubu Raya,

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Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan Toksisitas

Cited by 3 publications

References 6 publications

The hepatoprotective effect of Marchantia paleacea bertol. extract against acetaminophen-induced liver damage in rat: biochemical and histological evidence

The hepatoprotective effect of Marchantia paleacea bertol. extract against acetaminophen-induced liver damage in rat: biochemical and histological evidence

The Potential of Purple Sweet Potato-based Food Bar as an Immunomodulator and Hepatoprotector Against Diethylnitrosamine-induced Mice

Ethno-Medicinal Plants Used for Medication of Jaundice by The Chinese, Dayak, and Malays Ethnic in West Kalimantan, Indonesia

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