Review: Microbiome in Inflammatory Arthritis and Human Rheumatic Diseases

Scher, Jose U.; Littman, Dan R.; Abramson, Steven B.

doi:10.1002/art.39259

Cited by 207 publications

(199 citation statements)

References 95 publications

Supporting

Mentioning

187

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, recent studies have shown that fibrotic ILD is characterized by an increased distal alveolar bacterial burden that might be responsible for both a rapidly deteriorating course of fibrotic disease and deadly ‘exacerbations' [29]. The establishment via new DNA sequencing technologies of the long-time hypothetic theory that a disturbed lung microbiome could trigger and/or aggravate tissue injury in susceptible pulmonary fibrosis patients bears significant importance for CTD patients not only for its role in the development and maintenance of lung disease but also for its potential pathogenetic role in manifestations of the mater disease [62,63,64]. …”

Section: Acute Lung Infections In Ctdsmentioning

confidence: 99%

Acute Respiratory Events in Connective Tissue Disorders

Papiris¹,

Manali²,

Kolilekas³

et al. 2016

Respiration

View full text Add to dashboard Cite

Subacute-acute, hyperacute, or even catastrophic and fulminant respiratory events occur in almost all classic connective tissue disorders (CTDs); they may share systemic life-threatening manifestations, may precipitously lead to respiratory failure requiring ventilatory support as well as a combination of specific therapeutic measures, and in most affected patients constitute the devastating end-of-life event. In CTDs, acute respiratory events may be related to any respiratory compartment including the airways, lung parenchyma, alveolar capillaries, lung vessels, pleura, and ventilatory muscles. Acute respiratory events may also precipitate disease-specific extrapulmonary organ involvement such as aspiration pneumonia and lead to digestive tract involvement and heart-related respiratory events. Finally, antirheumatic drug-related acute respiratory toxicity as well as lung infections related to the rheumatic disease and/or to immunosuppression complete the spectrum of acute respiratory events. Overall, in CTDs the lungs significantly contribute to morbidity and mortality, since they constitute a common site of disease involvement; a major site of infections related to the ‘mater' disease; a major site of drug-related toxicity, and a common site of treatment-related infectious complications. The extreme spectrum of the abovementioned events, as well as the ‘vicious' coexistence of most of the aforementioned manifestations, requires skills, specific diagnostic and therapeutic means, and most of all a multidisciplinary approach of adequately prepared and expert scientists. Avoiding lung disease might represent a major concern for future advancements in the treatment of autoimmune disorders.

show abstract

Section: Acute Lung Infections In Ctdsmentioning

confidence: 99%

Acute Respiratory Events in Connective Tissue Disorders

Papiris¹,

Manali²,

Kolilekas³

et al. 2016

Respiration

View full text Add to dashboard Cite

show abstract

“…The ability of the microbiome to regulate gut inflammation and immune responses initiating at the gut boundary suggests, therefore, a potential role in regulating inflammatory arthritis. The role of the microbiome on inflammatory arthritis has been discussed in prior reviews [17, 18], which highlight an increasing collection of clinical and preclinical studies linking the gut microbiota to rheumatoid arthritis, psoriatic arthritis and spondyloarthritis. A recent study closely links Prevotella copri in the gut to rheumatoid arthritis [19].…”

Section: Inflammatory Arthritismentioning

confidence: 99%

The Microbiome and Bone and Joint Disease

Hernandez

2017

Curr Rheumatol Rep

View full text Add to dashboard Cite

Purpose of Review Changes in the constituents and activity of the microbiome have been associated with a number of conditions linked to bone and joint disease. This review concentrates on ways in which the microbiome is known to influence osteoarthritis and osteoporosis. Recent Findings Animal studies have demonstrated that changes in the microbiome can mediate the effects of obesity on cartilage degeneration. Additionally, the microbiome influences the amount of bone (bone quantity), as well as bone tissue material properties (bone quality). Early clinical findings support the effects of the microbiome on osteoporosis and osteoarthritis. Summary Although animal studies implicate the microbiome in the development of bone and joint disease, available results are limited and can be conflicting. Further investigation of the mechanisms leading from changes in the microbiome to alterations in bones and joints are necessary.

show abstract

“…Эта проблема детально рассмотрена в серии обзоров [156][157][158]. Обратимся лишь к некоторым данным, касаю-щимся потенциальной роли кишечной микробиоты в раз-витии РА.…”

Section: фак торы внешней средыunclassified

Problems of Rheumatoid Arthritis Immunopathology: Evolution of the Disease

Насонов¹

2017

rsp

View full text Add to dashboard Cite

Review: Microbiome in Inflammatory Arthritis and Human Rheumatic Diseases

Cited by 207 publications

References 95 publications

Acute Respiratory Events in Connective Tissue Disorders

Acute Respiratory Events in Connective Tissue Disorders

The Microbiome and Bone and Joint Disease

Problems of Rheumatoid Arthritis Immunopathology: Evolution of the Disease

Contact Info

Product

Resources

About