Review of bioactive compounds from fungi in the South China Sea

Abstract

A diverse array of bioactive metabolites have been isolated and characterized from fungi isolated from countries surrounding the South China Sea. From extensive studies of marine fungi of the South China Sea, 25 fungal strains (comprising endophytes, obligate and marine-derived fungi) were screened for bioactive compounds. This resulted in the reporting of 42 new or novel compounds and 35 known compounds (data from 1999–2007). Their biological activities, structural and stereochemical assignments and syntheses of some structurally unique natural products are reported.

Composition of endophytic fungal community associated with leaves of maize cultivated in south Brazilian field

“…All genera of fungi reported in this study have been associated with maize. Some in vegetative tissues such as Cochliobolus, Epicoccum, Phoma, and Diaporthe [45] and other in seeds such as Nigrospora sp., besides fungi already mentioned [46]. Alternaria, Cladosporium, and Fusarium are considered soil living fungi, which invade grains at pre-or post-harvest stage and can cause damage in corn before threshing [47].…”

MB1533 is a Defensin-Like Antimicrobial Peptide from the Intracellular Meristem Endophyte of Scots Pine Methylobacterium extorquens DSM13060

“…Lipopeptides syringomycins A1, E, G and pseudomycins are produced by Pseudomonas syringae and exhibit antimycotic activity [41][42][43]. Recently, two tetrapeptides, Cyclo-(Val-Leu-Val-Leu) and Cyclo-(LeuAla-Leu-Ala) were identified from Castaniopsis fissa [44]. Furthermore, Talaromins A and B were identified from the endophytic fungus Talaromyces wortmannii from Aloe vera and had no antibacterial activity against various strains of bacteria at 64 μg/ml [13].…”

Antimicrobial activity of marine fungi isolated from the Son Tra peninsula, Da Nang, Vietnam

“…This group of organisms has attracted considerable attention from natural product chemists, and diverse and unique compounds of marine fungi with pertinent biological activities including antimicrobial, anticancer, anti-inflammatory and antiviral properties have been reported (Bugni and Ireland, 2004;Pan et al, 2008). …”