Review of cardiovascular imaging in the journal of nuclear cardiology in 2016: Part 2 of 2—myocardial perfusion imaging

Abstract

In 2016, the Journal of Nuclear Cardiology published many high-quality articles. Similar to previous years, we will summarize here a selection of the articles that were published in the Journal in 2016 to provide a concise review of the main advancements that have recently occurred in the field. In the first article of this two-part series we focused on publications dealing with positron emission tomography, computed tomography, and magnetic resonance. This review will place emphasis on myocardial perfusion imaging using single-photon emission-computed tomography summarizing advances in the field including in diagnosis, prognosis, and appropriate use.

Utility of gated SPECT parameters in detection of coronary artery disease in patients with normal perfusion images

“…Although up to 7.2% of patients with normal perfusion images had CAD [12], correctable causes of false negative perfusion images must be excluded before the perfusion be considered normal. These causes include, but not limited to, unrecognized ingestion of caffeine-containing products, insufficient coronary vasodilatation, motion artifacts, and attenuation artifacts [2].…”

“…Some causes, such as inadequate stress, image acquisition errors, and imaging artifacts, can be prevented through careful patient preparation and proper imaging technique. Others, unfortunately, are inherent limitations of perfusion image interpretation and are more challenging to overcome [2].…”

Stable Isotopes for Tracing Cardiac Metabolism in Diseases

“…A given metabolite comprising n atoms may exist in either labeled or unlabeled states with 2 n isotopomers. For example, glucose (C 6 H 12 O 6 ) consists of 64 carbon atom isotopomers (n = 6, 2 6 ), 4,096 hydrogen atom isotopomers (n = 12, 2 12 ), and combined 2.6 × 10 5 (2 6 × 2 12 ) carbon and hydrogen isotopomers. Therefore, additional methods have been developed to allow the integration of multiple isotopic tracer systems (98).…”

“…Radioactive probes are a stable of both clinical cardiology and basic cardiovascular research (e.g., 18 F, 3 H, 14 C) and are used to study in vivo or ex vivo metabolic changes in the heart. There are several clinically relevant radiopharmaceuticals such as 99mtechnetium-sestamibi ( 99m TC-MIBI, or CardioLite) (6) or [ 18 F]-Fluorodeoxyglucose ([ 18 F]-FDG) (7) for interrogating metabolic parameters such as nutrient uptake rates. These probes allow safe, non-invasive tracing of metabolic changes in vivo.…”

Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2020: positron emission tomography, computed tomography, and magnetic resonance

“…It has been a tradition to summarize some of the key articles that were published each year. [1][2][3][4][5][6][7][8][9][10][11] This review is dedicated to the colleagues and loved ones we lost during the pandemic, and to the bright minds whose vigorous and endless efforts and dedication transcended all obstacles to provide us with these amazing papers. This review will specifically address articles published in the Journal relating to positron emission tomography (PET), cardiac computed tomography (CT), and cardiac magnetic resonance (CMR).…”