Review of Characteristics and Analytical Methods for Determination of Thiabendazole

Abstract

Thiabendazole (TBZ) is a fungicide and anthelmintic drug commonly found in food products. Due to its toxicity and potential carcinogenicity, its determination in various samples is important for public health. Different analytical methods can be used to determine the presence and concentration of TBZ in samples. Liquid chromatography (LC) and its subtypes, high-performance liquid chromatography (HPLC) and ultra-high-performance liquid chromatography (UHPLC), are the most commonly used methods for TBZ determination representing 19%, 18%, and 18% of the described methods, respectively. Surface-enhanced Raman spectroscopy (SERS) and fluorimetry are two more methods widely used for TBZ determination, representing 13% and 12% of the described methods, respectively. In this review, a number of methods for TBZ determination are described, but due to their limitations, there is a high potential for the further improvement and development of each method in order to obtain a simple, precise, and accurate method that can be used for routine analysis.

Parallel Synthesis of Piperazine Tethered Thiazole Compounds with Antiplasmodial Activity

“…Small molecules containing the thiazole moiety have been demonstrated to possess drug-like properties against a variety of diseases, resulting in, so far, 17 FDA-approved drugs containing the thiazole ring. The indications to which thiazole derivatives are prescribed include asthma (Cinalukast) [28], bacterial infections (Ceftizoxime) [29], diarrhea (Nitazoxanide) [30], myelogenous leukemia (Dasatinib) [31], pain (Meloxicam) [32], duodenal ulcers (famotidine) [33], anthelmintics (thiabendazole) [34], CNS neuroprotective and anticonvulsant (riluzole) [35], and vitamin (thiamine) [36].…”