Review of Drug Effectiveness in the Treatment of Alcoholism

Viamontes, Jorge

doi:10.1176/ajp.128.12.1570

Cited by 33 publications

(3 citation statements)

References 3 publications

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“…On the other hand, efficacy could not be confirmed in controlled trials with other antidepressants (O'SUllivan 1984;Viamontes 1972), thus limiting the conclusion that can be drawn from open studies.…”

Section: Discussionmentioning

confidence: 98%

Long Term Efficacy and Clinical Safety of Tianeptine in Depressed Alcoholic Patients after Alcohol Withdrawal

et al. 1990

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A multicentre study was designed to treat patients presenting with a major depressive episode, single or recurrent, or dysthymic disorder with tianeptine for I year. 22% of these patients had a concurrent diagnosis of alcoholism. This intermediate analysis presents results obtained with the first 122 depressed alcoholic patients included, of which 63 were treated for I year. The results allow the evaluation of the long term efficacy and tolerability of tianeptine.The antidepressant activity of tianeptine was confirmed by an almost 50% reduction of initial Montgomery-Asberg depression rating scale scores after I month of treatment. Total scores and subscores of the Hamilton anxiety rating scale and Hopkins symptom checklist self-ratings Improved concomitantly. Single item and factor scores of the checklist for assessment of somatic symptoms indicated improvement in complaints present at the beginning of the study and an absence of notable adverse effects, particularly of the anticholinergic type. Three patients took massive doses of tianeptine; despite the association with alcohol, these patients did not show marked adverse effects.These results indicate the potential of tianeptine as an antidepressant in alcoholic patients after withdrawal of alcohol, its long term efficacy, and its good tolerability in patients who are particularly susceptible to the adverse effects of psychotropic drugs. The drug does not provoke orthostatic hypotension or weight change.

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Section: Discussionmentioning

confidence: 98%

Long Term Efficacy and Clinical Safety of Tianeptine in Depressed Alcoholic Patients after Alcohol Withdrawal

et al. 1990

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“…Of particular importance is the question of specific treatment measures for depression in detoxified chronic alcohol-dependent patients. Clinical studies show that most of the affective symptoms disappear spontaneously after a few days or weeks of abstinence (Schuckit, 1986) and controlled trials with antidepressants failed to show convincing evidence of the efficacy of these drugs in depressed alcoholic patients (Viamontes, 1972;Ciraulo and Jaffe, 1981;O'SulIivan, 1984). On the other hand, one follow-up study found a persisting rate of 60% depressed alcohol-dependent patients after 1 year (Pottenger et al, 1978).…”

Section: Introductionmentioning

confidence: 99%

How depressive are male alcoholic inpatients? Psychometric results from the “Tübinger Alkoholismusprojekt“*

1991

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SummaryThere has been continued interest in the nature of the association between affective disorders and alcoholism. This may be due to the fact that during the course of alcoholism 30-70% of the patients suffer from mood disturbances meeting the criteria for severe depression, especially in periods of excessive alcohol consumption or during withdrawal. In the course of a prospective multidimensional study, Tiibinger Alkoholismusprojekt (T-ALK Study), symptoms of depression in 31 male alcohol-dependent patients (RDC diagnosis) were assessed using the Beck Depression Inventory (BDI) and the Freiburger Personlichkeitsinventar (FPI-R) at the beginning and at the end of a 6-week inpatient treatment program. There was only a moderate degree of depression (BDI) in 20% of the patients which decreased significantly during the psychotherapeutic treatment under conditions of confirmed abstinence. No correlations between the degree of depression and neuropsychological impairment were found. Although the “satisfaction with life” (FPI-R factor) was still impaired in a third of the patients at the end of that short-term treatment period, our results do not indicate a general nosological overlap between alcoholism and affective disorders in males.

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“…Up to now no pharmacological threatment has turned out to be crucial in the relief of the alcohol withdrawal syndrome (Funderburk et al, 1978;Viamontes, 1972); as a matter of fact, behavioral effects of alcohol are due to complex pathophysiological mechanisms involving hepatic, hemopoietic and CNS dysfunctions {Ellingboe, 1978; Layden and Smith, 1973 …”

Section: Introductionmentioning

confidence: 99%

Alcohol Withdrawal Syndrome: Treatment with Trazodone

Roccatagliatà¹,

Albano²,

Maffini³

et al. 1980

Int Pharmacopsychiatry

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Central monoaminergic pathways dysfunction has been shown in the alcohol withdrawal syndrome of experimental animals: noradrenergic hyperfunction and serotonin transmission impairment is suggested by many studies. Trazodone is a new psychotropic drug which has a marked norepinephrine receptor blocking power; moreover, it inhibits serotonin reuptake and was fully effective in the treatment of man's withdrawal syndrome (17 alcoholic inpatients). The good therapeutical results make it conceivable that monoaminergic pathways dysfunction has an important pathophysiological role in the alcohol withdrawal syndrome of man also.

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Review of Drug Effectiveness in the Treatment of Alcoholism

Cited by 33 publications

References 3 publications

Long Term Efficacy and Clinical Safety of Tianeptine in Depressed Alcoholic Patients after Alcohol Withdrawal

Long Term Efficacy and Clinical Safety of Tianeptine in Depressed Alcoholic Patients after Alcohol Withdrawal

How depressive are male alcoholic inpatients? Psychometric results from the “Tübinger Alkoholismusprojekt“*

Alcohol Withdrawal Syndrome: Treatment with Trazodone

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