Review of Exercise and the Risk of Benign Prostatic Hyperplasia

Sea, Jason; Poon, Kenneth S.; McVary, Kevin T.

doi:10.3810/psm.2009.12.1745

Cited by 28 publications

(15 citation statements)

References 87 publications

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“…These results suggest a promising role for tai chi in LUTS related to BPH. These results are consistent with previous reports that increased physical activity and exercise are consistently related to a decreased risk for BPH and LUTS [4, 8]. There is also a meta-analysis showing that physical activity is associated with a 25% decreased risk of BPH and LUTS compared to a sedentary life style [7].…”

Section: Discussionsupporting

confidence: 92%

“…These symptoms increase with age, showing that hyperactivity of the autonomic nervous system and hyperinsulinemia play important roles in the exacerbation of LUTS due to BPH [5, 6]. Also, increased physical activity has a negative correlation with LUTS and BPH symptoms [7, 8]. Based on these findings, researchers have recommended adequate exercise for patients with BPH because light physical activities will reduce insulin resistance and the activity of the autonomic nervous system.…”

Section: Introductionmentioning

confidence: 99%

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Tai Chi for Lower Urinary Tract Symptoms and Quality of Life in Elderly Patients with Benign Prostate Hypertrophy: A Randomized Controlled Trial

Jung

Lee

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Tai chi exercise has been recommended as suitable for the improvement of health in the elderly. The purpose of this study was to investigate the effects of tai chi on lower urinary tract symptoms (LUTSs), quality of life (QoL), and sex hormone levels in patients with benign prostate hypertrophy (BPH). The elderly patients with BPH were randomized to receive tai chi or usual care. Fifty-six participants were randomized into either the tai chi group (n = 28) or the control group (n = 28). After 12 weeks of treatment, the tai chi group showed significant improvement in LUTS and QoL. There was a significant effect of tai chi on testosterone but no significant effect on insulin or glucose. No serious adverse events were observed during the study period. In conclusion, our results suggest that 12 weeks of tai chi may improve LUTS and QoL in elderly patients with BPH.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Tai Chi for Lower Urinary Tract Symptoms and Quality of Life in Elderly Patients with Benign Prostate Hypertrophy: A Randomized Controlled Trial

Jung

Lee

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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“…Theoretically, physical activity may protect against LUTS development in both genders by decreasing resting sympathetic muscle tone, reducing systemic inflammation, and changing certain hormonal factors, particularly those relevant to metabolic syndrome. 4 Physical activity also helps maintain weight over time. Given that body mass index and waist circumference are associated with LUTS in women, 16, 17 weight maintenance effects may partly explain beneficial associations with physical activity.…”

Section: Discussionmentioning

confidence: 99%

Are Physical Activity, Smoking and Alcohol Consumption Associated with Lower Urinary Tract Symptoms in Men or Women? Results from a Population Based Observational Study

et al. 2012

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Purpose Lower Urinary Tract Symptoms (LUTS) are highly prevalent and reduce quality of life. Lifestyle behaviors and LUTS development are largely unexamined. The objective of this study was to investigate physical activity, smoking, and alcohol drinking and LUTS development in men and women. Materials and Methods Data were from a longitudinal observational study, the Boston Area Community Health Survey. Baseline (2002–2005) in-person interviews assessed activity, smoking and alcohol. Five-year follow-up interviews (2006–2010, N=4,145) assessed new reports of moderate-to-severe LUTS, defined by the American Urological Association Symptom Index (AUASI). Analysis used multivariable logistic regression. Results LUTS developed among 7.7% and 12.7% of at-risk men and women, respectively. Women were 68% less likely to develop LUTS (OR=0.32, 95% CI: 0.17–0.60, P<0.001) if they had high vs. low physically activity. Although the association was similar among men, it was not statistically significant upon adjustment for medical or sociodemographic characteristics in the multivariable model. Women smokers were twice as likely to develop LUTS, particularly storage symptoms (OR=2.15, 95% CI: 1.30–3.56, P=0.003), compared to never-smokers. Among men, smoking was not associated with LUTS. Results for alcohol intake were inconsistent by intake level and symptom subtype. Conclusions Low physical activity was associated with 2–3 times higher likelihood of LUTS development. Smoking may contribute to LUTS development in women, but not men. Clinicians should continue to promote physical activity and smoking cessation noting the additional potential benefits of LUTS prevention, particularly for women.

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“…A review of Sea et al (2009) highly supports a clinically significant, independent, and strong inverse relationship between exercise (Ex) and the development of BPH /LUTS [27]. Greater distances run per week may reduce BPH risk independent of BMI, 10 km performance, and diet [28].…”

Section: Introductionmentioning

confidence: 99%

Action Mechanism ofGinkgo bilobaLeaf Extract Intervened by Exercise Therapy in Treatment of Benign Prostate Hyperplasia

Peng

Liu

Chang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Benign prostatic hyperplasia (BPH), an imbalance between androgen/estrogen, overexpression of stromal, and epithelial growth factors associated with chronic inflammation, has become an atypical direct cause of mortality of aged male diseases. Ginkgo possesses anti-inflammatory, blood flow-enhancing, and free radical scavenging effects. Considering strenuous exercise can reduce BPH risks, we hypothesize Ginkgo + exercise (Ginkgo + Ex) could be beneficial to BPH. To verify this, rat BPH model was induced by s.c. 3.5 mg testosterone (T) and 0.1 mg estradiol (E2) per head per day successively for 8 weeks, using mineral oil as placebo. Cerenin® 8.33 μL/100 g was applied s.c. from the 10th to the 13th week, and simultaneously, Ex was applied (30 m/min, 3 times/week). In BPH, Ginkgo alone had no effect on T, 5α-reductase, and dihydrotestosterone (DHT), but suppressed androgen receptor (AR), aromatase, E2 and estrogen receptor (ER), and the proliferating cell nuclear antigen (PCNA); Ex alone significantly reduced T, aromatase, E2, ER, AR, and PCNA, but highly raised DHT. While Ginkgo + Ex androgenically downregulated T, aromatase, E2, and ER, but upregulated DHT, AR, and PCNA, implying Ginkgo + Ex tended to worsen BPH. Conclusively, Ginkgo or Ex alone may be more beneficial than Ginkgo + Ex for treatment of BPH.

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Review of Exercise and the Risk of Benign Prostatic Hyperplasia

Cited by 28 publications

References 87 publications

Tai Chi for Lower Urinary Tract Symptoms and Quality of Life in Elderly Patients with Benign Prostate Hypertrophy: A Randomized Controlled Trial

Tai Chi for Lower Urinary Tract Symptoms and Quality of Life in Elderly Patients with Benign Prostate Hypertrophy: A Randomized Controlled Trial

Are Physical Activity, Smoking and Alcohol Consumption Associated with Lower Urinary Tract Symptoms in Men or Women? Results from a Population Based Observational Study

Action Mechanism ofGinkgo bilobaLeaf Extract Intervened by Exercise Therapy in Treatment of Benign Prostate Hyperplasia

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